7N43

Alpha-conotoxin OmIA with unusual pharmacological properties at alpha7 nicotinic receptors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0043083	cellular_component	synaptic cleft
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0043083	cellular_component	synaptic cleft
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0043083	cellular_component	synaptic cleft
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0043083	cellular_component	synaptic cleft
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0043083	cellular_component	synaptic cleft
F	0005576	cellular_component	extracellular region
F	0030550	molecular_function	acetylcholine receptor inhibitor activity
F	0035792	cellular_component	host cell postsynaptic membrane
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity
G	0005576	cellular_component	extracellular region
G	0030550	molecular_function	acetylcholine receptor inhibitor activity
G	0035792	cellular_component	host cell postsynaptic membrane
G	0035821	biological_process	modulation of process of another organism
G	0090729	molecular_function	toxin activity
G	0099106	molecular_function	ion channel regulator activity
H	0005576	cellular_component	extracellular region
H	0030550	molecular_function	acetylcholine receptor inhibitor activity
H	0035792	cellular_component	host cell postsynaptic membrane
H	0035821	biological_process	modulation of process of another organism
H	0090729	molecular_function	toxin activity
H	0099106	molecular_function	ion channel regulator activity
I	0005576	cellular_component	extracellular region
I	0030550	molecular_function	acetylcholine receptor inhibitor activity
I	0035792	cellular_component	host cell postsynaptic membrane
I	0035821	biological_process	modulation of process of another organism
I	0090729	molecular_function	toxin activity
I	0099106	molecular_function	ion channel regulator activity
J	0005576	cellular_component	extracellular region
J	0030550	molecular_function	acetylcholine receptor inhibitor activity
J	0035792	cellular_component	host cell postsynaptic membrane
J	0035821	biological_process	modulation of process of another organism
J	0090729	molecular_function	toxin activity
J	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	15
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCShPACNvnnpHIC

Chain	Residue	Details
F	CYS2-CYS16

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	309
Details	Domain: {"description":"Ig-like"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	80
Details	Peptide: {"description":"Alpha-conotoxin OmIA","featureId":"PRO_0000247849","evidences":[{"source":"PubMed","id":"16803900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	15
Details	Site: {"description":"Key residue for the high potency for alpha-7 nAChRs","evidences":[{"source":"PubMed","id":"34955864","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	5
Details	Modified residue: {"description":"Glycine amide","evidences":[{"source":"PubMed","id":"16678128","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16803900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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