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7N43

Alpha-conotoxin OmIA with unusual pharmacological properties at alpha7 nicotinic receptors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005576cellular_componentextracellular region
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0043083cellular_componentsynaptic cleft
A0045202cellular_componentsynapse
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005576cellular_componentextracellular region
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0043083cellular_componentsynaptic cleft
B0045202cellular_componentsynapse
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005576cellular_componentextracellular region
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0043083cellular_componentsynaptic cleft
C0045202cellular_componentsynapse
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005576cellular_componentextracellular region
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0043083cellular_componentsynaptic cleft
D0045202cellular_componentsynapse
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005576cellular_componentextracellular region
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0043083cellular_componentsynaptic cleft
E0045202cellular_componentsynapse
F0005576cellular_componentextracellular region
F0030550molecular_functionacetylcholine receptor inhibitor activity
F0035792cellular_componenthost cell postsynaptic membrane
F0035821biological_processmodulation of process of another organism
F0090729molecular_functiontoxin activity
F0099106molecular_functionion channel regulator activity
G0005576cellular_componentextracellular region
G0030550molecular_functionacetylcholine receptor inhibitor activity
G0035792cellular_componenthost cell postsynaptic membrane
G0035821biological_processmodulation of process of another organism
G0090729molecular_functiontoxin activity
G0099106molecular_functionion channel regulator activity
H0005576cellular_componentextracellular region
H0030550molecular_functionacetylcholine receptor inhibitor activity
H0035792cellular_componenthost cell postsynaptic membrane
H0035821biological_processmodulation of process of another organism
H0090729molecular_functiontoxin activity
H0099106molecular_functionion channel regulator activity
I0005576cellular_componentextracellular region
I0030550molecular_functionacetylcholine receptor inhibitor activity
I0035792cellular_componenthost cell postsynaptic membrane
I0035821biological_processmodulation of process of another organism
I0090729molecular_functiontoxin activity
I0099106molecular_functionion channel regulator activity
J0005576cellular_componentextracellular region
J0030550molecular_functionacetylcholine receptor inhibitor activity
J0035792cellular_componenthost cell postsynaptic membrane
J0035821biological_processmodulation of process of another organism
J0090729molecular_functiontoxin activity
J0099106molecular_functionion channel regulator activity
Functional Information from PROSITE/UniProt
site_idPS60014
Number of Residues15
DetailsALPHA_CONOTOXIN Alpha-conotoxin family signature. CCShPACNvnnpHIC
ChainResidueDetails
FCYS2-CYS16

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsSITE: Key residue for the high potency for alpha-7 nAChRs => ECO:0000305|PubMed:34955864
ChainResidueDetails
FHIS5
IHIS5
IVAL10
IASN11
JHIS5
JVAL10
JASN11
FVAL10
FASN11
GHIS5
GVAL10
GASN11
HHIS5
HVAL10
HASN11

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: Glycine amide => ECO:0000269|PubMed:16678128, ECO:0000269|PubMed:16803900
ChainResidueDetails
FGLY17
GGLY17
HGLY17
IGLY17
JGLY17

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PDB entries from 2025-06-18

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