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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7N17

Structure of TAX-4_R421W apo open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003031biological_processdetection of carbon dioxide
A0005216molecular_functionmonoatomic ion channel activity
A0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006935biological_processchemotaxis
A0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
A0007399biological_processnervous system development
A0007602biological_processphototransduction
A0007606biological_processsensory perception of chemical stimulus
A0007635biological_processchemosensory behavior
A0009454biological_processaerotaxis
A0010628biological_processpositive regulation of gene expression
A0010754biological_processnegative regulation of cGMP-mediated signaling
A0016020cellular_componentmembrane
A0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030553molecular_functioncGMP binding
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0040010biological_processpositive regulation of growth rate
A0040040biological_processthermosensory behavior
A0042048biological_processolfactory behavior
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043052biological_processthermotaxis
A0045664biological_processregulation of neuron differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048812biological_processneuron projection morphogenesis
A0050907biological_processdetection of chemical stimulus involved in sensory perception
A0055085biological_processtransmembrane transport
A0055093biological_processresponse to hyperoxia
A0070482biological_processresponse to oxygen levels
A0071805biological_processpotassium ion transmembrane transport
A0097543cellular_componentciliary inversin compartment
A0097730cellular_componentnon-motile cilium
A0098655biological_processmonoatomic cation transmembrane transport
B0000166molecular_functionnucleotide binding
B0003031biological_processdetection of carbon dioxide
B0005216molecular_functionmonoatomic ion channel activity
B0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006935biological_processchemotaxis
B0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
B0007399biological_processnervous system development
B0007602biological_processphototransduction
B0007606biological_processsensory perception of chemical stimulus
B0007635biological_processchemosensory behavior
B0009454biological_processaerotaxis
B0010628biological_processpositive regulation of gene expression
B0010754biological_processnegative regulation of cGMP-mediated signaling
B0016020cellular_componentmembrane
B0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
B0019722biological_processcalcium-mediated signaling
B0030425cellular_componentdendrite
B0030516biological_processregulation of axon extension
B0030553molecular_functioncGMP binding
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0040010biological_processpositive regulation of growth rate
B0040040biological_processthermosensory behavior
B0042048biological_processolfactory behavior
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043052biological_processthermotaxis
B0045664biological_processregulation of neuron differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048812biological_processneuron projection morphogenesis
B0050907biological_processdetection of chemical stimulus involved in sensory perception
B0055085biological_processtransmembrane transport
B0055093biological_processresponse to hyperoxia
B0070482biological_processresponse to oxygen levels
B0071805biological_processpotassium ion transmembrane transport
B0097543cellular_componentciliary inversin compartment
B0097730cellular_componentnon-motile cilium
B0098655biological_processmonoatomic cation transmembrane transport
C0000166molecular_functionnucleotide binding
C0003031biological_processdetection of carbon dioxide
C0005216molecular_functionmonoatomic ion channel activity
C0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006935biological_processchemotaxis
C0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
C0007399biological_processnervous system development
C0007602biological_processphototransduction
C0007606biological_processsensory perception of chemical stimulus
C0007635biological_processchemosensory behavior
C0009454biological_processaerotaxis
C0010628biological_processpositive regulation of gene expression
C0010754biological_processnegative regulation of cGMP-mediated signaling
C0016020cellular_componentmembrane
C0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
C0019722biological_processcalcium-mediated signaling
C0030425cellular_componentdendrite
C0030516biological_processregulation of axon extension
C0030553molecular_functioncGMP binding
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0040010biological_processpositive regulation of growth rate
C0040040biological_processthermosensory behavior
C0042048biological_processolfactory behavior
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043052biological_processthermotaxis
C0045664biological_processregulation of neuron differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048812biological_processneuron projection morphogenesis
C0050907biological_processdetection of chemical stimulus involved in sensory perception
C0055085biological_processtransmembrane transport
C0055093biological_processresponse to hyperoxia
C0070482biological_processresponse to oxygen levels
C0071805biological_processpotassium ion transmembrane transport
C0097543cellular_componentciliary inversin compartment
C0097730cellular_componentnon-motile cilium
C0098655biological_processmonoatomic cation transmembrane transport
D0000166molecular_functionnucleotide binding
D0003031biological_processdetection of carbon dioxide
D0005216molecular_functionmonoatomic ion channel activity
D0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006935biological_processchemotaxis
D0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
D0007399biological_processnervous system development
D0007602biological_processphototransduction
D0007606biological_processsensory perception of chemical stimulus
D0007635biological_processchemosensory behavior
D0009454biological_processaerotaxis
D0010628biological_processpositive regulation of gene expression
D0010754biological_processnegative regulation of cGMP-mediated signaling
D0016020cellular_componentmembrane
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0030516biological_processregulation of axon extension
D0030553molecular_functioncGMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0040010biological_processpositive regulation of growth rate
D0040040biological_processthermosensory behavior
D0042048biological_processolfactory behavior
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043052biological_processthermotaxis
D0045664biological_processregulation of neuron differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048812biological_processneuron projection morphogenesis
D0050907biological_processdetection of chemical stimulus involved in sensory perception
D0055085biological_processtransmembrane transport
D0055093biological_processresponse to hyperoxia
D0070482biological_processresponse to oxygen levels
D0071805biological_processpotassium ion transmembrane transport
D0097543cellular_componentciliary inversin compartment
D0097730cellular_componentnon-motile cilium
D0098655biological_processmonoatomic cation transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGReMYIVkrG
ChainResidueDetails
AILE520-GLY536
site_idPS00889
Number of Residues24
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElSIlniagskngnrRTAnVrS
ChainResidueDetails
APHE558-SER581
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues352
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues212
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues52
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=P-helix","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WEL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"28099415","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues308
DetailsRegion: {"description":"C-linker","evidences":[{"source":"PubMed","id":"28099415","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues456
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"PubMed","id":"28099415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35233102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28099415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35233102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35233102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28099415","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues8
DetailsSite: {"description":"Central gate","evidences":[{"source":"PubMed","id":"32483338","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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