Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7N0N

Activated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0008285	biological_process	negative regulation of cell population proliferation
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0030027	cellular_component	lamellipodium
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098703	biological_process	calcium ion import across plasma membrane
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0008285	biological_process	negative regulation of cell population proliferation
B	0012505	cellular_component	endomembrane system
B	0016020	cellular_component	membrane
B	0030027	cellular_component	lamellipodium
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098703	biological_process	calcium ion import across plasma membrane
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0008285	biological_process	negative regulation of cell population proliferation
C	0012505	cellular_component	endomembrane system
C	0016020	cellular_component	membrane
C	0030027	cellular_component	lamellipodium
C	0042470	cellular_component	melanosome
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098703	biological_process	calcium ion import across plasma membrane
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0008285	biological_process	negative regulation of cell population proliferation
D	0012505	cellular_component	endomembrane system
D	0016020	cellular_component	membrane
D	0030027	cellular_component	lamellipodium
D	0042470	cellular_component	melanosome
D	0042802	molecular_function	identical protein binding
D	0043025	cellular_component	neuronal cell body
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098703	biological_process	calcium ion import across plasma membrane
D	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	136
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	184
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	180
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	140
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	192
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	132
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)