7N0K
Cryo-EM structure of TACAN in the apo form (TMEM120A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005637 | cellular_component | nuclear inner membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0051291 | biological_process | protein heterooligomerization |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005637 | cellular_component | nuclear inner membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0051291 | biological_process | protein heterooligomerization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 376 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32084332 |
| Chain | Residue | Details |
| B | MET1-LYS135 | |
| B | ASN184-LYS190 | |
| B | GLN241-THR273 | |
| B | ARG327-ASP343 | |
| A | MET1-LYS135 | |
| A | ASN184-LYS190 | |
| A | GLN241-THR273 | |
| A | ARG327-ASP343 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE136-ASN156 | |
| A | PHE136-ASN156 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:32084332 |
| Chain | Residue | Details |
| B | SER157-ALA162 | |
| B | ASP212-GLN222 | |
| B | ASN295-TRP305 | |
| A | SER157-ALA162 | |
| A | ASP212-GLN222 | |
| A | ASN295-TRP305 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA163-ILE183 | |
| A | ALA163-ILE183 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY191-PRO211 | |
| A | GLY191-PRO211 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE223-TYR240 | |
| A | PHE223-TYR240 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE274-PHE294 | |
| A | PHE274-PHE294 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| B | GLN306-LEU326 | |
| A | GLN306-LEU326 |
