7MPY

Crystal structure of cytosolic HPPK-DHPS from A.thaliana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A	0004156	molecular_function	dihydropteroate synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B	0004156	molecular_function	dihydropteroate synthase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00792
Number of Residues	16
Details	DHPS_1 Dihydropteroate synthase signature 1. VmGILNlTpDSFsDgG

Chain	Residue	Details
A	VAL204-GLY219

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site_id	PS00793
Number of Residues	14
Details	DHPS_2 Dihydropteroate synthase signature 2. GVdIIDIGAqsTrP

Chain	Residue	Details
A	GLY238-PRO251

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site_id	PS00794
Number of Residues	12
Details	HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RyGPRplDLDIL

Chain	Residue	Details
A	ARG98-LEU109

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P9WND1

Chain	Residue	Details
A	ASN209
B	ASN209

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0AC13

Chain	Residue	Details
A	THR249
B	ASP378
B	LYS423
B	ARG458
A	ASP286
A	ASN305
A	ASP378
A	LYS423
A	ARG458
B	THR249
B	ASP286
B	ASN305

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