7MP2

CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH 1D-MYO-INOSITOL 1,5-BISDIPHOSPHATE TETRAKISPHOSPHATE (1,5-PP IP4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0002031	biological_process	G protein-coupled receptor internalization
A	0002046	molecular_function	opsin binding
A	0005829	cellular_component	cytosol
A	0007165	biological_process	signal transduction
A	0007600	biological_process	sensory perception
A	0016020	cellular_component	membrane
A	0042995	cellular_component	cell projection
A	0051219	molecular_function	phosphoprotein binding
B	0001664	molecular_function	G protein-coupled receptor binding
B	0001750	cellular_component	photoreceptor outer segment
B	0001917	cellular_component	photoreceptor inner segment
B	0002031	biological_process	G protein-coupled receptor internalization
B	0002046	molecular_function	opsin binding
B	0005829	cellular_component	cytosol
B	0007165	biological_process	signal transduction
B	0007600	biological_process	sensory perception
B	0016020	cellular_component	membrane
B	0042995	cellular_component	cell projection
B	0051219	molecular_function	phosphoprotein binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001750	cellular_component	photoreceptor outer segment
C	0001917	cellular_component	photoreceptor inner segment
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002046	molecular_function	opsin binding
C	0005829	cellular_component	cytosol
C	0007165	biological_process	signal transduction
C	0007600	biological_process	sensory perception
C	0016020	cellular_component	membrane
C	0042995	cellular_component	cell projection
C	0051219	molecular_function	phosphoprotein binding
D	0001664	molecular_function	G protein-coupled receptor binding
D	0001750	cellular_component	photoreceptor outer segment
D	0001917	cellular_component	photoreceptor inner segment
D	0002031	biological_process	G protein-coupled receptor internalization
D	0002046	molecular_function	opsin binding
D	0005829	cellular_component	cytosol
D	0007165	biological_process	signal transduction
D	0007600	biological_process	sensory perception
D	0016020	cellular_component	membrane
D	0042995	cellular_component	cell projection
D	0051219	molecular_function	phosphoprotein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue I8P A 501

Chain	Residue
A	LYS15
A	ARG171
A	LYS300
A	HIS301
A	ALA381
A	ARG382
A	ASN384
B	GLU314

---

site_id	AC2
Number of Residues	9
Details	binding site for residue I8P B 501

Chain	Residue
B	ARG171
B	LEU173
B	LYS298
B	LYS300
B	HIS301
B	ALA381
B	ARG382
B	ASN384
B	LYS15

---

site_id	AC3
Number of Residues	5
Details	binding site for residue I8P C 501

Chain	Residue
B	LYS163
B	LYS166
C	LYS238
C	THR258
C	LYS332

---

site_id	AC4
Number of Residues	6
Details	binding site for residue I8P C 502

Chain	Residue
C	LYS15
C	LYS166
C	ARG171
C	LYS298
C	LYS300
C	HIS301

---

site_id	AC5
Number of Residues	7
Details	binding site for residue I8P D 501

Chain	Residue
D	LYS15
D	ARG171
D	LEU173
D	LYS298
D	LYS300
D	HIS301
D	ALA381

---

site_id	AC6
Number of Residues	8
Details	binding site for residue I8P D 502

Chain	Residue
A	LYS238
A	LEU240
A	THR258
A	LYS332
D	LYS163
D	PRO165
D	LYS166
D	LYS167

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Functional Information from PROSITE/UniProt

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGqEDiDVMGLsFrRDL

Chain	Residue	Details
A	PHE65-LEU83

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylmethionine; partial => ECO:0000269|PubMed:3478675

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P15887

Chain	Residue	Details
A	THR230
B	THR230
C	THR230
D	THR230

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