7MP1
CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH 1,5-DI-METHYLENEBISPHOSPHONATE INOSITOL TETRAKISPHOSPHATE (1,5-PCP-IP4)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0001750 | cellular_component | photoreceptor outer segment |
| A | 0001917 | cellular_component | photoreceptor inner segment |
| A | 0002031 | biological_process | G protein-coupled receptor internalization |
| A | 0005829 | cellular_component | cytosol |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0042995 | cellular_component | cell projection |
| B | 0001664 | molecular_function | G protein-coupled receptor binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0001917 | cellular_component | photoreceptor inner segment |
| B | 0002031 | biological_process | G protein-coupled receptor internalization |
| B | 0005829 | cellular_component | cytosol |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0042995 | cellular_component | cell projection |
| C | 0001664 | molecular_function | G protein-coupled receptor binding |
| C | 0001750 | cellular_component | photoreceptor outer segment |
| C | 0001917 | cellular_component | photoreceptor inner segment |
| C | 0002031 | biological_process | G protein-coupled receptor internalization |
| C | 0005829 | cellular_component | cytosol |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0042995 | cellular_component | cell projection |
| D | 0001664 | molecular_function | G protein-coupled receptor binding |
| D | 0001750 | cellular_component | photoreceptor outer segment |
| D | 0001917 | cellular_component | photoreceptor inner segment |
| D | 0002031 | biological_process | G protein-coupled receptor internalization |
| D | 0005829 | cellular_component | cytosol |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| D | 0042995 | cellular_component | cell projection |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue 4WZ B 501 |
| Chain | Residue |
| B | LYS15 |
| B | ARG171 |
| B | LEU173 |
| B | LYS298 |
| B | LYS300 |
| B | HIS301 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 4WZ B 502 |
| Chain | Residue |
| C | LYS238 |
| C | ILE256 |
| C | LYS257 |
| C | LYS332 |
| B | LYS163 |
| B | LYS167 |
| C | GLN137 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 4WZ C 501 |
| Chain | Residue |
| C | LYS15 |
| C | LYS166 |
| C | ARG171 |
| C | LEU172 |
| C | LEU173 |
| C | LYS298 |
| C | LYS300 |
| C | HIS301 |
| C | ALA381 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue 4WZ D 501 |
| Chain | Residue |
| A | LYS238 |
| A | GLU242 |
| A | LYS332 |
| D | LYS163 |
| D | LYS167 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue 4WZ D 502 |
| Chain | Residue |
| D | LYS15 |
| D | ARG171 |
| D | LEU173 |
| D | LYS298 |
| D | LYS300 |
| D | HIS301 |
Functional Information from PROSITE/UniProt
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGqEDiDVMGLsFrRDL |
| Chain | Residue | Details |
| A | PHE65-LEU83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylmethionine; partial => ECO:0000269|PubMed:3478675 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P15887 |
| Chain | Residue | Details |
| A | THR230 | |
| B | THR230 | |
| C | THR230 | |
| D | THR230 |
