7MOQ

The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005929	cellular_component	cilium
A	0007018	biological_process	microtubule-based movement
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0030286	cellular_component	dynein complex
A	0031514	cellular_component	motile cilium
A	0042995	cellular_component	cell projection
A	0045505	molecular_function	dynein intermediate chain binding
A	0051959	molecular_function	dynein light intermediate chain binding
B	0000166	molecular_function	nucleotide binding
B	0003777	molecular_function	microtubule motor activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005929	cellular_component	cilium
B	0007018	biological_process	microtubule-based movement
B	0008017	molecular_function	microtubule binding
B	0008569	molecular_function	minus-end-directed microtubule motor activity
B	0030286	cellular_component	dynein complex
B	0036156	cellular_component	inner dynein arm
B	0036159	biological_process	inner dynein arm assembly
B	0042995	cellular_component	cell projection
B	0045505	molecular_function	dynein intermediate chain binding
B	0051959	molecular_function	dynein light intermediate chain binding
B	0060294	biological_process	cilium movement involved in cell motility
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005858	cellular_component	axonemal dynein complex
C	0005874	cellular_component	microtubule
C	0005929	cellular_component	cilium
C	0007018	biological_process	microtubule-based movement
C	0008569	molecular_function	minus-end-directed microtubule motor activity
C	0030286	cellular_component	dynein complex
C	0042995	cellular_component	cell projection
C	0045505	molecular_function	dynein intermediate chain binding
C	0051959	molecular_function	dynein light intermediate chain binding
d	0003341	biological_process	cilium movement
d	0005856	cellular_component	cytoskeleton
d	0005874	cellular_component	microtubule
d	0007018	biological_process	microtubule-based movement
d	0030286	cellular_component	dynein complex
d	0036157	cellular_component	outer dynein arm
d	0036158	biological_process	outer dynein arm assembly
d	0042995	cellular_component	cell projection
d	0045503	molecular_function	dynein light chain binding
d	0045504	molecular_function	dynein heavy chain binding
D	0003341	biological_process	cilium movement
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007018	biological_process	microtubule-based movement
D	0030286	cellular_component	dynein complex
D	0036157	cellular_component	outer dynein arm
D	0036158	biological_process	outer dynein arm assembly
D	0042995	cellular_component	cell projection
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
e	0003341	biological_process	cilium movement
e	0005737	cellular_component	cytoplasm
e	0005856	cellular_component	cytoskeleton
e	0005874	cellular_component	microtubule
e	0005929	cellular_component	cilium
e	0007018	biological_process	microtubule-based movement
e	0030286	cellular_component	dynein complex
e	0031514	cellular_component	motile cilium
e	0036157	cellular_component	outer dynein arm
e	0036158	biological_process	outer dynein arm assembly
e	0042995	cellular_component	cell projection
e	0045503	molecular_function	dynein light chain binding
e	0045504	molecular_function	dynein heavy chain binding
E	0003341	biological_process	cilium movement
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005929	cellular_component	cilium
E	0007018	biological_process	microtubule-based movement
E	0030286	cellular_component	dynein complex
E	0031514	cellular_component	motile cilium
E	0036157	cellular_component	outer dynein arm
E	0036158	biological_process	outer dynein arm assembly
E	0042995	cellular_component	cell projection
E	0045503	molecular_function	dynein light chain binding
E	0045504	molecular_function	dynein heavy chain binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0015031	biological_process	protein transport
H	0030286	cellular_component	dynein complex
H	0045505	molecular_function	dynein intermediate chain binding
H	0051028	biological_process	mRNA transport
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005929	cellular_component	cilium
I	0007017	biological_process	microtubule-based process
I	0030286	cellular_component	dynein complex
I	0042995	cellular_component	cell projection
I	0045505	molecular_function	dynein intermediate chain binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0015031	biological_process	protein transport
J	0030286	cellular_component	dynein complex
J	0045505	molecular_function	dynein intermediate chain binding
J	0051028	biological_process	mRNA transport
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0030286	cellular_component	dynein complex
K	0045505	molecular_function	dynein intermediate chain binding
L	0007017	biological_process	microtubule-based process
L	0030286	cellular_component	dynein complex
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005868	cellular_component	cytoplasmic dynein complex
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0015031	biological_process	protein transport
M	0030286	cellular_component	dynein complex
M	0045505	molecular_function	dynein intermediate chain binding
M	0051028	biological_process	mRNA transport
N	0005737	cellular_component	cytoplasm
N	0005868	cellular_component	cytoplasmic dynein complex
N	0007018	biological_process	microtubule-based movement
N	0045505	molecular_function	dynein intermediate chain binding
O	0005737	cellular_component	cytoplasm
O	0005868	cellular_component	cytoplasmic dynein complex
O	0007018	biological_process	microtubule-based movement
O	0045505	molecular_function	dynein intermediate chain binding
P	0015035	molecular_function	protein-disulfide reductase activity
P	0045454	biological_process	cell redox homeostasis
q	0000166	molecular_function	nucleotide binding
q	0003924	molecular_function	GTPase activity
q	0005200	molecular_function	structural constituent of cytoskeleton
q	0005525	molecular_function	GTP binding
q	0005737	cellular_component	cytoplasm
q	0005856	cellular_component	cytoskeleton
q	0005874	cellular_component	microtubule
q	0007010	biological_process	cytoskeleton organization
q	0007017	biological_process	microtubule-based process
q	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007010	biological_process	cytoskeleton organization
Q	0007017	biological_process	microtubule-based process
Q	0046872	molecular_function	metal ion binding
r	0000166	molecular_function	nucleotide binding
r	0005200	molecular_function	structural constituent of cytoskeleton
r	0005525	molecular_function	GTP binding
r	0005737	cellular_component	cytoplasm
r	0005856	cellular_component	cytoskeleton
r	0005874	cellular_component	microtubule
r	0007010	biological_process	cytoskeleton organization
r	0007017	biological_process	microtubule-based process
r	0016787	molecular_function	hydrolase activity
r	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007010	biological_process	cytoskeleton organization
R	0007017	biological_process	microtubule-based process
R	0016787	molecular_function	hydrolase activity
R	0046872	molecular_function	metal ion binding
s	0000166	molecular_function	nucleotide binding
s	0005200	molecular_function	structural constituent of cytoskeleton
s	0005525	molecular_function	GTP binding
s	0005737	cellular_component	cytoplasm
s	0005856	cellular_component	cytoskeleton
s	0005874	cellular_component	microtubule
s	0007010	biological_process	cytoskeleton organization
s	0007017	biological_process	microtubule-based process
s	0016787	molecular_function	hydrolase activity
s	0046872	molecular_function	metal ion binding
S	0000166	molecular_function	nucleotide binding
S	0005200	molecular_function	structural constituent of cytoskeleton
S	0005525	molecular_function	GTP binding
S	0005737	cellular_component	cytoplasm
S	0005856	cellular_component	cytoskeleton
S	0005874	cellular_component	microtubule
S	0007010	biological_process	cytoskeleton organization
S	0007017	biological_process	microtubule-based process
S	0016787	molecular_function	hydrolase activity
S	0046872	molecular_function	metal ion binding
u	0000166	molecular_function	nucleotide binding
u	0003924	molecular_function	GTPase activity
u	0005200	molecular_function	structural constituent of cytoskeleton
u	0005525	molecular_function	GTP binding
u	0005737	cellular_component	cytoplasm
u	0005856	cellular_component	cytoskeleton
u	0005874	cellular_component	microtubule
u	0007010	biological_process	cytoskeleton organization
u	0007017	biological_process	microtubule-based process
u	0046872	molecular_function	metal ion binding
U	0000166	molecular_function	nucleotide binding
U	0003924	molecular_function	GTPase activity
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005525	molecular_function	GTP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005874	cellular_component	microtubule
U	0007010	biological_process	cytoskeleton organization
U	0007017	biological_process	microtubule-based process
U	0046872	molecular_function	metal ion binding
w	0000166	molecular_function	nucleotide binding
w	0005200	molecular_function	structural constituent of cytoskeleton
w	0005525	molecular_function	GTP binding
w	0005737	cellular_component	cytoplasm
w	0005856	cellular_component	cytoskeleton
w	0005874	cellular_component	microtubule
w	0007010	biological_process	cytoskeleton organization
w	0007017	biological_process	microtubule-based process
w	0016787	molecular_function	hydrolase activity
w	0046872	molecular_function	metal ion binding
W	0000166	molecular_function	nucleotide binding
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005525	molecular_function	GTP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005874	cellular_component	microtubule
W	0007010	biological_process	cytoskeleton organization
W	0007017	biological_process	microtubule-based process
W	0016787	molecular_function	hydrolase activity
W	0046872	molecular_function	metal ion binding
X	0003341	biological_process	cilium movement
X	0005929	cellular_component	cilium
X	0035253	cellular_component	ciliary rootlet
X	0036064	cellular_component	ciliary basal body
X	0036158	biological_process	outer dynein arm assembly
X	0097542	cellular_component	ciliary tip
y	0000166	molecular_function	nucleotide binding
y	0003924	molecular_function	GTPase activity
y	0005200	molecular_function	structural constituent of cytoskeleton
y	0005525	molecular_function	GTP binding
y	0005737	cellular_component	cytoplasm
y	0005856	cellular_component	cytoskeleton
y	0005874	cellular_component	microtubule
y	0007010	biological_process	cytoskeleton organization
y	0007017	biological_process	microtubule-based process
y	0046872	molecular_function	metal ion binding
Y	0000166	molecular_function	nucleotide binding
Y	0003924	molecular_function	GTPase activity
Y	0005200	molecular_function	structural constituent of cytoskeleton
Y	0005525	molecular_function	GTP binding
Y	0005737	cellular_component	cytoplasm
Y	0005856	cellular_component	cytoskeleton
Y	0005874	cellular_component	microtubule
Y	0007010	biological_process	cytoskeleton organization
Y	0007017	biological_process	microtubule-based process
Y	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVdFFasWCGPCKiLaeqF

Chain	Residue	Details
P	LEU25-PHE43

---

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. DFRs.RYHGTWHCI

Chain	Residue	Details
H	ASP48-ILE60

---

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
u	GLY140-GLY146
s	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
u	MET1-ILE4

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FGCQAVH

Chain	Residue	Details
K	PHE84-HIS90

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IGGGcyNgLLAVWDG

Chain	Residue	Details
e	ILE231-GLY245

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
R	GLU254
U	GLY142
U	THR143
U	GLY144
U	ASN204
U	ASN226
Y	GLN11
Y	SER138
Y	GLY142
Y	THR143
Y	GLY144
S	GLU254
Y	ASN204
Y	ASN226
u	GLN11
u	SER138
u	GLY142
u	THR143
u	GLY144
u	ASN204
u	ASN226
q	GLN11
W	GLU254
q	SER138
q	GLY142
q	THR143
q	GLY144
q	ASN204
q	ASN226
y	GLN11
y	SER138
y	GLY142
y	THR143
s	GLU254
y	GLY144
y	ASN204
y	ASN226
r	GLU254
w	GLU254
Q	ASN226
U	GLN11
U	SER138

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
R	GLN11
S	GLU71
S	SER140
S	GLY144
S	THR145
S	THR179
S	ASN206
S	ASN228
W	GLN11
W	GLU71
W	SER140
R	GLU71
W	GLY144
W	THR145
W	THR179
W	ASN206
W	ASN228
s	GLN11
s	GLU71
s	SER140
s	GLY144
s	THR145
R	SER140
s	THR179
s	ASN206
s	ASN228
r	GLN11
r	GLU71
r	SER140
r	GLY144
r	THR145
r	THR179
r	ASN206
R	GLY144
r	ASN228
w	GLN11
w	GLU71
w	SER140
w	GLY144
w	THR145
w	THR179
w	ASN206
w	ASN228
R	THR145
R	THR179
R	ASN206
R	ASN228
S	GLN11

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Involved in polymerization

Chain	Residue	Details
R	TYR449
S	TYR449
W	TYR449
s	TYR449
r	TYR449
w	TYR449

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:7775576

Chain	Residue	Details
R	LYS40
S	LYS40
W	LYS40
s	LYS40
r	LYS40
w	LYS40

---