Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | CYS150 |
| A | LYS151 |
| A | ARG152 |
| A | GLY153 |
| A | LYS154 |
| A | HIS155 |
| A | ARG156 |
| A | HOH631 |
| A | HOH649 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue BME A 502 |
| Chain | Residue |
| A | VAL62 |
| A | ASP63 |
| A | ARG165 |
| A | GLN168 |
| A | TRP170 |
| A | CYS212 |
| A | SER213 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| B | CYS150 |
| B | LYS151 |
| B | ARG152 |
| B | GLY153 |
| B | LYS154 |
| B | HIS155 |
| B | ARG156 |
| B | HOH647 |
| B | HOH688 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue BME B 502 |
| Chain | Residue |
| B | VAL62 |
| B | ARG165 |
| B | GLN168 |
| B | TRP170 |
| B | CYS212 |
| B | SER213 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue BME B 503 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue BME B 504 |
| Chain | Residue |
| B | ILE109 |
| B | HOH650 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue BME B 505 |
| Chain | Residue |
| B | SER106 |
| B | GLY108 |
| B | HOH734 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkrGkhRTG |
| Chain | Residue | Details |
| A | ILE148-GLY158 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 302 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Region: {"description":"WPD loop important for active site topology","evidences":[{"source":"PubMed","id":"35468885","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"7MOF","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P53965","evidenceCode":"ECO:0000250"}]} |
