7MLT

Crystal structure of ricin A chain in complex with 5-(2-ethylphenyl)thiophene-2-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	ASN132
A	LEU133
A	ASN136
A	HOH646

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 303

Chain	Residue
A	ARG114
A	HOH455
A	HOH474

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 304

Chain	Residue
A	HOH497
A	ILE8
A	ARG31

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO A 305

Chain	Residue
A	HOH576

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 306

Chain	Residue
A	HIS94
A	PRO95
A	ASN97
A	GLN98

---

site_id	AC6
Number of Residues	8
Details	binding site for residue EDO A 307

Chain	Residue
A	GLY186
A	GLU187
A	THR190
A	ARG235
A	SER246
A	ILE249
A	HOH498
A	HOH528

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 308

Chain	Residue
A	ASN78
A	ARG258
A	HOH475

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 309

Chain	Residue
A	GLN128
A	GLY131
A	EDO321
A	HOH516

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 310

Chain	Residue
A	ASN141
A	GLY142
A	PRO143
A	ASN195
A	ARG196
A	ARG197
A	HOH401
A	HOH535

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 311

Chain	Residue
A	GLN19
A	THR22
A	VAL38
A	HIS40
A	ILE42
A	PRO43
A	HOH456

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO A 312

Chain	Residue
A	PHE119
A	GLY120
A	ASN122
A	ARG125

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 313

Chain	Residue
A	PRO43
A	ARG189
A	HOH403
A	HOH410

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 314

Chain	Residue
A	GLU61
A	GLU67
A	SER69
A	VAL70
A	THR71
A	ARG85
A	ALA86
A	GLY87

---

site_id	AD5
Number of Residues	7
Details	binding site for residue EDO A 315

Chain	Residue
A	PHE117
A	PHE119
A	TYR154
A	GLN160
A	LEU161
A	HOH477
A	HOH580

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 316

Chain	Residue
A	ASN23
A	ARG26
A	ALA27
A	HOH437

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 317

Chain	Residue
A	GLN182
A	GLN182
A	ILE249
A	PRO250
A	HOH420

---

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO A 318

Chain	Residue
A	ASN136
A	ILE137
A	GLU138
A	ARG166
A	HOH431
A	HOH534

---

site_id	AD9
Number of Residues	8
Details	binding site for residue EDO A 319

Chain	Residue
A	GLU146
A	THR163
A	ARG166
A	SER167
A	ILE170
A	HOH503
A	HOH532
A	HOH534

---

site_id	AE1
Number of Residues	7
Details	binding site for residue EDO A 320

Chain	Residue
A	GLU135
A	PRO200
A	ASP201
A	PRO202
A	HOH493
A	HOH579
A	HOH627

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO A 321

Chain	Residue
A	GLN128
A	LEU133
A	EDO309
A	HOH545
A	GLN128

---

site_id	AE3
Number of Residues	7
Details	binding site for residue ZJD A 322

Chain	Residue
A	TYR183
A	ARG234
A	ARG235
A	PHE240
A	ILE247
A	ILE247
A	HOH525

---

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM

Chain	Residue	Details
A	ILE172-MET188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P84531","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8780513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000080","evidences":[{"source":"PubMed","id":"1368517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","featureId":"CAR_000081","evidences":[{"source":"PubMed","id":"1368517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---