7MLQ

X-ray crystal structure of human BRD4(D1) in complex with 2-(4-{5-[6-(2,5-dibromophenoxy)pyridin-2-yl]-4-methyl-1H-1,2,3-triazol-1-yl}piperidin-1-yl)-N,N-dimethylethan-1-amine (compound 26)

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 201

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135
A	HOH384

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site_id	AC2
Number of Residues	9
Details	binding site for residue ZHV A 202

Chain	Residue
A	TYR139
A	ASN140
A	MET149
A	HOH328
A	HOH335
A	HOH379
A	TRP81
A	PRO82
A	LYS99

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site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 203

Chain	Residue
A	ASP144
A	ASP145
A	HOH477

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 204

Chain	Residue
A	ALA89
A	PRO95

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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