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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ML3

General transcription factor TFIIH (weak binding)

Functional Information from GO Data
ChainGOidnamespacecontents
00000019biological_processregulation of mitotic recombination
00000112cellular_componentnucleotide-excision repair factor 3 complex
00000166molecular_functionnucleotide binding
00000439cellular_componenttranscription factor TFIIH core complex
00003676molecular_functionnucleic acid binding
00003677molecular_functionDNA binding
00003678molecular_functionDNA helicase activity
00003684molecular_functiondamaged DNA binding
00004386molecular_functionhelicase activity
00005515molecular_functionprotein binding
00005524molecular_functionATP binding
00005634cellular_componentnucleus
00005675cellular_componenttranscription factor TFIIH holo complex
00005829cellular_componentcytosol
00006139biological_processnucleobase-containing compound metabolic process
00006281biological_processDNA repair
00006289biological_processnucleotide-excision repair
00006351biological_processDNA-templated transcription
00006366biological_processtranscription by RNA polymerase II
00006367biological_processtranscription initiation at RNA polymerase II promoter
00006974biological_processDNA damage response
00008094molecular_functionATP-dependent activity, acting on DNA
00016787molecular_functionhydrolase activity
00016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
00016853molecular_functionisomerase activity
00016887molecular_functionATP hydrolysis activity
00043139molecular_function5'-3' DNA helicase activity
00045951biological_processpositive regulation of mitotic recombination
00046872molecular_functionmetal ion binding
00051536molecular_functioniron-sulfur cluster binding
00051539molecular_function4 iron, 4 sulfur cluster binding
10000439cellular_componenttranscription factor TFIIH core complex
10006289biological_processnucleotide-excision repair
10006351biological_processDNA-templated transcription
20000112cellular_componentnucleotide-excision repair factor 3 complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006351biological_processDNA-templated transcription
20006366biological_processtranscription by RNA polymerase II
20006367biological_processtranscription initiation at RNA polymerase II promoter
20006974biological_processDNA damage response
30000993molecular_functionRNA polymerase II complex binding
30001174biological_processtranscriptional start site selection at RNA polymerase II promoter
30005515molecular_functionprotein binding
30005634cellular_componentnucleus
30005675cellular_componenttranscription factor TFIIH holo complex
30006281biological_processDNA repair
30006289biological_processnucleotide-excision repair
30006351biological_processDNA-templated transcription
30006357biological_processregulation of transcription by RNA polymerase II
30006366biological_processtranscription by RNA polymerase II
30006367biological_processtranscription initiation at RNA polymerase II promoter
30008270molecular_functionzinc ion binding
30045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
30046872molecular_functionmetal ion binding
30061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
30070985cellular_componenttranscription factor TFIIK complex
40000112cellular_componentnucleotide-excision repair factor 3 complex
40000439cellular_componenttranscription factor TFIIH core complex
40005515molecular_functionprotein binding
40005634cellular_componentnucleus
40005675cellular_componenttranscription factor TFIIH holo complex
40006281biological_processDNA repair
40006289biological_processnucleotide-excision repair
40006351biological_processDNA-templated transcription
40006355biological_processregulation of DNA-templated transcription
40006366biological_processtranscription by RNA polymerase II
40006367biological_processtranscription initiation at RNA polymerase II promoter
40006974biological_processDNA damage response
40008270molecular_functionzinc ion binding
40016251molecular_functionRNA polymerase II general transcription initiation factor activity
40046872molecular_functionmetal ion binding
50000439cellular_componenttranscription factor TFIIH core complex
50000993molecular_functionRNA polymerase II complex binding
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005675cellular_componenttranscription factor TFIIH holo complex
50005829cellular_componentcytosol
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006351biological_processDNA-templated transcription
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
50006974biological_processDNA damage response
60000112cellular_componentnucleotide-excision repair factor 3 complex
60000439cellular_componenttranscription factor TFIIH core complex
60005515molecular_functionprotein binding
60005634cellular_componentnucleus
60005675cellular_componenttranscription factor TFIIH holo complex
60006281biological_processDNA repair
60006289biological_processnucleotide-excision repair
60006351biological_processDNA-templated transcription
60006357biological_processregulation of transcription by RNA polymerase II
60006366biological_processtranscription by RNA polymerase II
60006367biological_processtranscription initiation at RNA polymerase II promoter
60006974biological_processDNA damage response
60008270molecular_functionzinc ion binding
60046872molecular_functionmetal ion binding
60061630molecular_functionubiquitin protein ligase activity
70000019biological_processregulation of mitotic recombination
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000166molecular_functionnucleotide binding
70000439cellular_componenttranscription factor TFIIH core complex
70001111biological_processRNA polymerase II promoter clearance
70001113biological_processtranscription open complex formation at RNA polymerase II promoter
70001174biological_processtranscriptional start site selection at RNA polymerase II promoter
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70004386molecular_functionhelicase activity
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005675cellular_componenttranscription factor TFIIH holo complex
70005829cellular_componentcytosol
70006281biological_processDNA repair
70006289biological_processnucleotide-excision repair
70006351biological_processDNA-templated transcription
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70006974biological_processDNA damage response
70015616molecular_functionDNA translocase activity
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70016973biological_processpoly(A)+ mRNA export from nucleus
70043138molecular_function3'-5' DNA helicase activity
70097550cellular_componenttranscription preinitiation complex
Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. SEEL
ChainResidueDetails
3SER318-LEU321
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Ced..CkqeFcvdcdvfiHeil..H
ChainResidueDetails
6CYS429-HIS449
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CyHrICesCV
ChainResidueDetails
3CYS34-VAL43
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SiVIFDEAHN
ChainResidueDetails
0SER230-ASN239
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues47
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues440
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P18074","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues36
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues179
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues154
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsMotif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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