7MKF
Paired helical tau filament extracted from PrP-CAA Patient brain tissue | tau filament | PHF Tau
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0015631 | molecular_function | tubulin binding |
| B | 0008017 | molecular_function | microtubule binding |
| B | 0015631 | molecular_function | tubulin binding |
| C | 0008017 | molecular_function | microtubule binding |
| C | 0015631 | molecular_function | tubulin binding |
| D | 0008017 | molecular_function | microtubule binding |
| D | 0015631 | molecular_function | tubulin binding |
| E | 0008017 | molecular_function | microtubule binding |
| E | 0015631 | molecular_function | tubulin binding |
| F | 0008017 | molecular_function | microtubule binding |
| F | 0015631 | molecular_function | tubulin binding |
| G | 0008017 | molecular_function | microtubule binding |
| G | 0015631 | molecular_function | tubulin binding |
| H | 0008017 | molecular_function | microtubule binding |
| H | 0015631 | molecular_function | tubulin binding |
| I | 0008017 | molecular_function | microtubule binding |
| I | 0015631 | molecular_function | tubulin binding |
| J | 0008017 | molecular_function | microtubule binding |
| J | 0015631 | molecular_function | tubulin binding |
Functional Information from PROSITE/UniProt
| site_id | PS00229 |
| Number of Residues | 13 |
| Details | TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG |
| Chain | Residue | Details |
| A | GLY261-GLY273 | |
| A | GLY292-GLY304 | |
| A | GLY323-GLY335 | |
| A | GLY355-GLY367 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 310 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| A | LYS24 | |
| D | TYR394 | |
| E | LYS24 | |
| E | LYS44 | |
| E | LYS67 | |
| E | ASN381 | |
| E | GLU391 | |
| E | ILE392 | |
| E | TYR394 | |
| F | LYS24 | |
| F | LYS44 | |
| F | LYS67 | |
| F | ASN381 | |
| F | GLU391 | |
| F | ILE392 | |
| F | TYR394 | |
| G | LYS24 | |
| G | LYS44 | |
| G | LYS67 | |
| G | ASN381 | |
| G | GLU391 | |
| G | ILE392 | |
| G | TYR394 | |
| A | LYS44 | |
| H | LYS24 | |
| H | LYS44 | |
| H | LYS67 | |
| H | ASN381 | |
| H | GLU391 | |
| H | ILE392 | |
| H | TYR394 | |
| I | LYS24 | |
| I | LYS44 | |
| I | LYS67 | |
| I | ASN381 | |
| I | GLU391 | |
| I | ILE392 | |
| I | TYR394 | |
| J | LYS24 | |
| J | LYS44 | |
| J | LYS67 | |
| J | ASN381 | |
| J | GLU391 | |
| J | ILE392 | |
| J | TYR394 | |
| A | LYS67 | |
| B | LYS24 | |
| B | LYS44 | |
| B | LYS67 | |
| B | ASN381 | |
| B | GLU391 | |
| B | ILE392 | |
| B | TYR394 | |
| A | ASN381 | |
| A | GLU391 | |
| A | ILE392 | |
| C | LYS24 | |
| C | LYS44 | |
| C | LYS67 | |
| C | ASN381 | |
| C | GLU391 | |
| C | ILE392 | |
| C | TYR394 | |
| A | TYR394 | |
| D | LYS24 | |
| D | LYS44 | |
| D | LYS67 | |
| D | ASN381 | |
| D | GLU391 | |
| D | ILE392 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244 |
| Chain | Residue | Details |
| A | ALA2 | |
| J | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 | |
| G | ALA2 | |
| H | ALA2 | |
| I | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081 |
| Chain | Residue | Details |
| A | TYR18 | |
| J | TYR18 | |
| B | TYR18 | |
| C | TYR18 | |
| D | TYR18 | |
| E | TYR18 | |
| F | TYR18 | |
| G | TYR18 | |
| H | TYR18 | |
| I | TYR18 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | TYR29 | |
| F | TYR29 | |
| G | TYR29 | |
| H | TYR29 | |
| I | TYR29 | |
| J | TYR29 | |
| B | TYR29 | |
| C | TYR29 | |
| D | TYR29 | |
| E | TYR29 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| A | SER46 | |
| E | SER61 | |
| F | SER46 | |
| F | SER61 | |
| G | SER46 | |
| G | SER61 | |
| H | SER46 | |
| H | SER61 | |
| I | SER46 | |
| I | SER61 | |
| J | SER46 | |
| A | SER61 | |
| J | SER61 | |
| B | SER46 | |
| B | SER61 | |
| C | SER46 | |
| C | SER61 | |
| D | SER46 | |
| D | SER61 | |
| E | SER46 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 50 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | THR69 | |
| C | THR69 | |
| C | THR111 | |
| D | THR69 | |
| D | THR111 | |
| A | THR111 | |
| E | THR69 | |
| E | THR111 | |
| F | THR69 | |
| F | THR111 | |
| G | THR69 | |
| G | THR111 | |
| H | THR69 | |
| H | THR111 | |
| I | THR69 | |
| I | THR111 | |
| J | THR69 | |
| J | THR111 | |
| B | THR69 | |
| B | THR111 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| A | THR71 | |
| J | THR71 | |
| B | THR71 | |
| C | THR71 | |
| D | THR71 | |
| E | THR71 | |
| F | THR71 | |
| G | THR71 | |
| H | THR71 | |
| I | THR71 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696 |
| Chain | Residue | Details |
| A | SER214 | |
| J | SER214 | |
| B | SER214 | |
| C | SER214 | |
| D | SER214 | |
| E | SER214 | |
| F | SER214 | |
| G | SER214 | |
| H | SER214 | |
| I | SER214 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; in PHF-tau => ECO:0000269|PubMed:1899488 |
| Chain | Residue | Details |
| A | SER396 | |
| J | SER396 | |
| B | SER396 | |
| C | SER396 | |
| D | SER396 | |
| E | SER396 | |
| F | SER396 | |
| G | SER396 | |
| H | SER396 | |
| I | SER396 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 110 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | MOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 30 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 20 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 10 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 30 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI36 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI37 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI38 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI39 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI40 |
| Number of Residues | 130 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| A | LYS87 | |
| I | LYS87 | |
| I | LYS383 | |
| J | LYS87 | |
| J | LYS383 | |
| B | LYS87 | |
| B | LYS383 | |
| A | LYS383 | |
| C | LYS87 | |
| C | LYS383 | |
| D | LYS87 | |
| D | LYS383 | |
| E | LYS87 | |
| E | LYS383 | |
| F | LYS87 | |
| F | LYS383 | |
| G | LYS87 | |
| G | LYS383 | |
| H | LYS87 | |
| H | LYS383 |
| site_id | SWS_FT_FI41 |
| Number of Residues | 20 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI42 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI43 |
| Number of Residues | 30 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | LYS44 | |
| D | LYS44 | |
| E | LYS44 | |
| F | LYS44 | |
| G | LYS44 | |
| H | LYS44 | |
| I | LYS44 | |
| J | LYS44 | |
| B | LYS44 | |
| C | LYS44 |
| site_id | SWS_FT_FI44 |
| Number of Residues | 110 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI45 |
| Number of Residues | 30 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
