7MKA

Structure of EC+EC (leading EC-focused)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000428	cellular_component	DNA-directed RNA polymerase complex
a	0001172	biological_process	RNA-templated transcription
a	0003677	molecular_function	DNA binding
a	0003899	molecular_function	DNA-directed RNA polymerase activity
a	0003968	molecular_function	RNA-directed RNA polymerase activity
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005665	cellular_component	RNA polymerase II, core complex
a	0005739	cellular_component	mitochondrion
a	0006351	biological_process	DNA-templated transcription
a	0006366	biological_process	transcription by RNA polymerase II
a	0006367	biological_process	transcription initiation at RNA polymerase II promoter
a	0006368	biological_process	transcription elongation by RNA polymerase II
a	0006369	biological_process	termination of RNA polymerase II transcription
a	0008270	molecular_function	zinc ion binding
a	0010494	cellular_component	cytoplasmic stress granule
a	0016740	molecular_function	transferase activity
a	0016779	molecular_function	nucleotidyltransferase activity
a	0019985	biological_process	translesion synthesis
a	0034062	molecular_function	5'-3' RNA polymerase activity
a	0042789	biological_process	mRNA transcription by RNA polymerase II
a	0046872	molecular_function	metal ion binding
b	0000428	cellular_component	DNA-directed RNA polymerase complex
b	0001172	biological_process	RNA-templated transcription
b	0003676	molecular_function	nucleic acid binding
b	0003677	molecular_function	DNA binding
b	0003729	molecular_function	mRNA binding
b	0003899	molecular_function	DNA-directed RNA polymerase activity
b	0003968	molecular_function	RNA-directed RNA polymerase activity
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005665	cellular_component	RNA polymerase II, core complex
b	0005739	cellular_component	mitochondrion
b	0006351	biological_process	DNA-templated transcription
b	0006354	biological_process	DNA-templated transcription elongation
b	0006366	biological_process	transcription by RNA polymerase II
b	0006367	biological_process	transcription initiation at RNA polymerase II promoter
b	0006368	biological_process	transcription elongation by RNA polymerase II
b	0008270	molecular_function	zinc ion binding
b	0010494	cellular_component	cytoplasmic stress granule
b	0016740	molecular_function	transferase activity
b	0016779	molecular_function	nucleotidyltransferase activity
b	0032549	molecular_function	ribonucleoside binding
b	0034062	molecular_function	5'-3' RNA polymerase activity
b	0046872	molecular_function	metal ion binding
c	0000428	cellular_component	DNA-directed RNA polymerase complex
c	0001172	biological_process	RNA-templated transcription
c	0003677	molecular_function	DNA binding
c	0003899	molecular_function	DNA-directed RNA polymerase activity
c	0003968	molecular_function	RNA-directed RNA polymerase activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005665	cellular_component	RNA polymerase II, core complex
c	0006351	biological_process	DNA-templated transcription
c	0006366	biological_process	transcription by RNA polymerase II
c	0006367	biological_process	transcription initiation at RNA polymerase II promoter
c	0006368	biological_process	transcription elongation by RNA polymerase II
c	0006369	biological_process	termination of RNA polymerase II transcription
c	0008270	molecular_function	zinc ion binding
c	0046872	molecular_function	metal ion binding
c	0046983	molecular_function	protein dimerization activity
d	0000166	molecular_function	nucleotide binding
d	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
d	0000428	cellular_component	DNA-directed RNA polymerase complex
d	0000932	cellular_component	P-body
d	0001172	biological_process	RNA-templated transcription
d	0003697	molecular_function	single-stranded DNA binding
d	0003727	molecular_function	single-stranded RNA binding
d	0003968	molecular_function	RNA-directed RNA polymerase activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005665	cellular_component	RNA polymerase II, core complex
d	0005737	cellular_component	cytoplasm
d	0006352	biological_process	DNA-templated transcription initiation
d	0006366	biological_process	transcription by RNA polymerase II
d	0006367	biological_process	transcription initiation at RNA polymerase II promoter
d	0006368	biological_process	transcription elongation by RNA polymerase II
d	0006397	biological_process	mRNA processing
d	0030880	cellular_component	RNA polymerase complex
d	0031369	molecular_function	translation initiation factor binding
d	0045948	biological_process	positive regulation of translational initiation
e	0000428	cellular_component	DNA-directed RNA polymerase complex
e	0001172	biological_process	RNA-templated transcription
e	0003677	molecular_function	DNA binding
e	0003899	molecular_function	DNA-directed RNA polymerase activity
e	0003968	molecular_function	RNA-directed RNA polymerase activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005665	cellular_component	RNA polymerase II, core complex
e	0005666	cellular_component	RNA polymerase III complex
e	0005736	cellular_component	RNA polymerase I complex
e	0006351	biological_process	DNA-templated transcription
e	0006360	biological_process	transcription by RNA polymerase I
e	0006361	biological_process	transcription initiation at RNA polymerase I promoter
e	0006362	biological_process	transcription elongation by RNA polymerase I
e	0006363	biological_process	termination of RNA polymerase I transcription
e	0006366	biological_process	transcription by RNA polymerase II
e	0006367	biological_process	transcription initiation at RNA polymerase II promoter
e	0006368	biological_process	transcription elongation by RNA polymerase II
e	0006383	biological_process	transcription by RNA polymerase III
e	0006384	biological_process	transcription initiation at RNA polymerase III promoter
e	0006386	biological_process	termination of RNA polymerase III transcription
e	0042254	biological_process	ribosome biogenesis
e	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
e	0042797	biological_process	tRNA transcription by RNA polymerase III
f	0000428	cellular_component	DNA-directed RNA polymerase complex
f	0001172	biological_process	RNA-templated transcription
f	0003677	molecular_function	DNA binding
f	0003899	molecular_function	DNA-directed RNA polymerase activity
f	0003968	molecular_function	RNA-directed RNA polymerase activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005665	cellular_component	RNA polymerase II, core complex
f	0005666	cellular_component	RNA polymerase III complex
f	0005736	cellular_component	RNA polymerase I complex
f	0005737	cellular_component	cytoplasm
f	0006351	biological_process	DNA-templated transcription
f	0006360	biological_process	transcription by RNA polymerase I
f	0006361	biological_process	transcription initiation at RNA polymerase I promoter
f	0006362	biological_process	transcription elongation by RNA polymerase I
f	0006363	biological_process	termination of RNA polymerase I transcription
f	0006366	biological_process	transcription by RNA polymerase II
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0006368	biological_process	transcription elongation by RNA polymerase II
f	0006383	biological_process	transcription by RNA polymerase III
f	0006384	biological_process	transcription initiation at RNA polymerase III promoter
f	0006386	biological_process	termination of RNA polymerase III transcription
f	0042254	biological_process	ribosome biogenesis
f	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
f	0042797	biological_process	tRNA transcription by RNA polymerase III
g	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
g	0000428	cellular_component	DNA-directed RNA polymerase complex
g	0000932	cellular_component	P-body
g	0000956	biological_process	nuclear-transcribed mRNA catabolic process
g	0001172	biological_process	RNA-templated transcription
g	0003676	molecular_function	nucleic acid binding
g	0003697	molecular_function	single-stranded DNA binding
g	0003727	molecular_function	single-stranded RNA binding
g	0003968	molecular_function	RNA-directed RNA polymerase activity
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005665	cellular_component	RNA polymerase II, core complex
g	0005737	cellular_component	cytoplasm
g	0006351	biological_process	DNA-templated transcription
g	0006352	biological_process	DNA-templated transcription initiation
g	0006366	biological_process	transcription by RNA polymerase II
g	0006367	biological_process	transcription initiation at RNA polymerase II promoter
g	0006368	biological_process	transcription elongation by RNA polymerase II
g	0031369	molecular_function	translation initiation factor binding
g	0045948	biological_process	positive regulation of translational initiation
g	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
h	0000428	cellular_component	DNA-directed RNA polymerase complex
h	0001172	biological_process	RNA-templated transcription
h	0003677	molecular_function	DNA binding
h	0003899	molecular_function	DNA-directed RNA polymerase activity
h	0003968	molecular_function	RNA-directed RNA polymerase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005665	cellular_component	RNA polymerase II, core complex
h	0005666	cellular_component	RNA polymerase III complex
h	0005736	cellular_component	RNA polymerase I complex
h	0006351	biological_process	DNA-templated transcription
h	0006360	biological_process	transcription by RNA polymerase I
h	0006361	biological_process	transcription initiation at RNA polymerase I promoter
h	0006362	biological_process	transcription elongation by RNA polymerase I
h	0006363	biological_process	termination of RNA polymerase I transcription
h	0006366	biological_process	transcription by RNA polymerase II
h	0006367	biological_process	transcription initiation at RNA polymerase II promoter
h	0006368	biological_process	transcription elongation by RNA polymerase II
h	0006383	biological_process	transcription by RNA polymerase III
h	0006384	biological_process	transcription initiation at RNA polymerase III promoter
h	0006386	biological_process	termination of RNA polymerase III transcription
h	0042254	biological_process	ribosome biogenesis
h	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
h	0042797	biological_process	tRNA transcription by RNA polymerase III
i	0000428	cellular_component	DNA-directed RNA polymerase complex
i	0001172	biological_process	RNA-templated transcription
i	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
i	0003676	molecular_function	nucleic acid binding
i	0003899	molecular_function	DNA-directed RNA polymerase activity
i	0003968	molecular_function	RNA-directed RNA polymerase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005665	cellular_component	RNA polymerase II, core complex
i	0005730	cellular_component	nucleolus
i	0006281	biological_process	DNA repair
i	0006283	biological_process	transcription-coupled nucleotide-excision repair
i	0006351	biological_process	DNA-templated transcription
i	0006366	biological_process	transcription by RNA polymerase II
i	0006367	biological_process	transcription initiation at RNA polymerase II promoter
i	0006368	biological_process	transcription elongation by RNA polymerase II
i	0006974	biological_process	DNA damage response
i	0008270	molecular_function	zinc ion binding
i	0046872	molecular_function	metal ion binding
j	0000428	cellular_component	DNA-directed RNA polymerase complex
j	0001172	biological_process	RNA-templated transcription
j	0003677	molecular_function	DNA binding
j	0003899	molecular_function	DNA-directed RNA polymerase activity
j	0003968	molecular_function	RNA-directed RNA polymerase activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005665	cellular_component	RNA polymerase II, core complex
j	0005666	cellular_component	RNA polymerase III complex
j	0005730	cellular_component	nucleolus
j	0005736	cellular_component	RNA polymerase I complex
j	0006351	biological_process	DNA-templated transcription
j	0006360	biological_process	transcription by RNA polymerase I
j	0006361	biological_process	transcription initiation at RNA polymerase I promoter
j	0006362	biological_process	transcription elongation by RNA polymerase I
j	0006363	biological_process	termination of RNA polymerase I transcription
j	0006366	biological_process	transcription by RNA polymerase II
j	0006367	biological_process	transcription initiation at RNA polymerase II promoter
j	0006368	biological_process	transcription elongation by RNA polymerase II
j	0006383	biological_process	transcription by RNA polymerase III
j	0006384	biological_process	transcription initiation at RNA polymerase III promoter
j	0006386	biological_process	termination of RNA polymerase III transcription
j	0008270	molecular_function	zinc ion binding
j	0042254	biological_process	ribosome biogenesis
j	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
j	0042797	biological_process	tRNA transcription by RNA polymerase III
j	0046872	molecular_function	metal ion binding
k	0000428	cellular_component	DNA-directed RNA polymerase complex
k	0001172	biological_process	RNA-templated transcription
k	0003677	molecular_function	DNA binding
k	0003899	molecular_function	DNA-directed RNA polymerase activity
k	0003968	molecular_function	RNA-directed RNA polymerase activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005665	cellular_component	RNA polymerase II, core complex
k	0006351	biological_process	DNA-templated transcription
k	0006366	biological_process	transcription by RNA polymerase II
k	0006367	biological_process	transcription initiation at RNA polymerase II promoter
k	0006368	biological_process	transcription elongation by RNA polymerase II
k	0006369	biological_process	termination of RNA polymerase II transcription
k	0046983	molecular_function	protein dimerization activity
l	0000428	cellular_component	DNA-directed RNA polymerase complex
l	0001172	biological_process	RNA-templated transcription
l	0003677	molecular_function	DNA binding
l	0003899	molecular_function	DNA-directed RNA polymerase activity
l	0003968	molecular_function	RNA-directed RNA polymerase activity
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005665	cellular_component	RNA polymerase II, core complex
l	0005666	cellular_component	RNA polymerase III complex
l	0005730	cellular_component	nucleolus
l	0005736	cellular_component	RNA polymerase I complex
l	0005737	cellular_component	cytoplasm
l	0005777	cellular_component	peroxisome
l	0006351	biological_process	DNA-templated transcription
l	0006360	biological_process	transcription by RNA polymerase I
l	0006361	biological_process	transcription initiation at RNA polymerase I promoter
l	0006362	biological_process	transcription elongation by RNA polymerase I
l	0006363	biological_process	termination of RNA polymerase I transcription
l	0006366	biological_process	transcription by RNA polymerase II
l	0006367	biological_process	transcription initiation at RNA polymerase II promoter
l	0006368	biological_process	transcription elongation by RNA polymerase II
l	0006383	biological_process	transcription by RNA polymerase III
l	0006384	biological_process	transcription initiation at RNA polymerase III promoter
l	0006386	biological_process	termination of RNA polymerase III transcription
l	0008270	molecular_function	zinc ion binding
l	0042254	biological_process	ribosome biogenesis
l	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
l	0042797	biological_process	tRNA transcription by RNA polymerase III
l	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
a	TYR1549-ALA1555
a	TYR1612-SER1618
a	TYR1619-SER1625
a	TYR1626-SER1632
a	TYR1633-SER1639
a	TYR1640-SER1646
a	TYR1647-SER1653
a	TYR1654-ALA1660
a	TYR1661-SER1667
a	TYR1668-SER1674
a	TYR1675-SER1681
a	TYR1556-SER1562
a	TYR1682-SER1688
a	TYR1689-ASN1695
a	TYR1696-SER1702
a	TYR1563-SER1569
a	TYR1570-SER1576
a	TYR1577-SER1583
a	TYR1584-SER1590
a	TYR1591-SER1597
a	TYR1598-SER1604
a	TYR1605-SER1611

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP

Chain	Residue	Details
c	ASN31-PRO71

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkChsrenvffqSQQRRkDTSmvlffvCls...CshiF

Chain	Residue	Details
i	CYS75-PHE110

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRDCNNMLypredkennrllfeCrtC

Chain	Residue	Details
i	PHE6-CYS32

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE

Chain	Residue	Details
e	HIS147-GLU160

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
f	THR86-GLN100

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG

Chain	Residue	Details
j	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP

Chain	Residue	Details
k	PHE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
b	GLY977-THR989

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"Lid loop"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Region: {"description":"Rudder loop"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Bridging helix"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23151482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25652824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	11
Details	Region: {"description":"Fork loop 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	13
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	23
Details	Region: {"description":"Non-specific ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	25
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11313498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11805306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11313499","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11313498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11805306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11313499","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15537538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TWF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 788

Chain

Residue

Details

---