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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7MJQ

Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0005242molecular_functioninward rectifier potassium channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0008282cellular_componentinward rectifying potassium channel
A0015272molecular_functionATP-activated inward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0017098molecular_functionsulfonylurea receptor binding
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030016cellular_componentmyofibril
A0031004cellular_componentpotassium ion-transporting ATPase complex
A0042383cellular_componentsarcolemma
A0048787cellular_componentpresynaptic active zone membrane
A0055085biological_processtransmembrane transport
A0098793cellular_componentpresynapse
A0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A1990573biological_processpotassium ion import across plasma membrane
B0001822biological_processkidney development
B0005242molecular_functioninward rectifier potassium channel activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0008282cellular_componentinward rectifying potassium channel
B0015272molecular_functionATP-activated inward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0017098molecular_functionsulfonylurea receptor binding
B0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
B0030016cellular_componentmyofibril
B0031004cellular_componentpotassium ion-transporting ATPase complex
B0042383cellular_componentsarcolemma
B0048787cellular_componentpresynaptic active zone membrane
B0055085biological_processtransmembrane transport
B0098793cellular_componentpresynapse
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B1990573biological_processpotassium ion import across plasma membrane
C0001822biological_processkidney development
C0005242molecular_functioninward rectifier potassium channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0008282cellular_componentinward rectifying potassium channel
C0015272molecular_functionATP-activated inward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0017098molecular_functionsulfonylurea receptor binding
C0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
C0030016cellular_componentmyofibril
C0031004cellular_componentpotassium ion-transporting ATPase complex
C0042383cellular_componentsarcolemma
C0048787cellular_componentpresynaptic active zone membrane
C0055085biological_processtransmembrane transport
C0098793cellular_componentpresynapse
C0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C1990573biological_processpotassium ion import across plasma membrane
D0001822biological_processkidney development
D0005242molecular_functioninward rectifier potassium channel activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006813biological_processpotassium ion transport
D0008282cellular_componentinward rectifying potassium channel
D0015272molecular_functionATP-activated inward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0017098molecular_functionsulfonylurea receptor binding
D0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
D0030016cellular_componentmyofibril
D0031004cellular_componentpotassium ion-transporting ATPase complex
D0042383cellular_componentsarcolemma
D0048787cellular_componentpresynaptic active zone membrane
D0055085biological_processtransmembrane transport
D0098793cellular_componentpresynapse
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D1990573biological_processpotassium ion import across plasma membrane
E0001669cellular_componentacrosomal vesicle
E0005267molecular_functionpotassium channel activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006813biological_processpotassium ion transport
E0006932biological_processsubstrate-dependent cell migration, cell contraction
E0008281molecular_functionsulfonylurea receptor activity
E0008282cellular_componentinward rectifying potassium channel
E0009410biological_processresponse to xenobiotic stimulus
E0015459molecular_functionpotassium channel regulator activity
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
E0022857molecular_functiontransmembrane transporter activity
E0030315cellular_componentT-tubule
E0031004cellular_componentpotassium ion-transporting ATPase complex
E0032991cellular_componentprotein-containing complex
E0033198biological_processresponse to ATP
E0042383cellular_componentsarcolemma
E0055085biological_processtransmembrane transport
E0071805biological_processpotassium ion transmembrane transport
E0098655biological_processmonoatomic cation transmembrane transport
E0099104molecular_functionpotassium channel activator activity
E0140359molecular_functionABC-type transporter activity
E1901363molecular_functionheterocyclic compound binding
E1990573biological_processpotassium ion import across plasma membrane
G0001669cellular_componentacrosomal vesicle
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005886cellular_componentplasma membrane
G0006813biological_processpotassium ion transport
G0006932biological_processsubstrate-dependent cell migration, cell contraction
G0008281molecular_functionsulfonylurea receptor activity
G0008282cellular_componentinward rectifying potassium channel
G0009410biological_processresponse to xenobiotic stimulus
G0015459molecular_functionpotassium channel regulator activity
G0016020cellular_componentmembrane
G0016887molecular_functionATP hydrolysis activity
G0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
G0022857molecular_functiontransmembrane transporter activity
G0030315cellular_componentT-tubule
G0031004cellular_componentpotassium ion-transporting ATPase complex
G0032991cellular_componentprotein-containing complex
G0033198biological_processresponse to ATP
G0042383cellular_componentsarcolemma
G0055085biological_processtransmembrane transport
G0071805biological_processpotassium ion transmembrane transport
G0098655biological_processmonoatomic cation transmembrane transport
G0099104molecular_functionpotassium channel activator activity
G0140359molecular_functionABC-type transporter activity
G1901363molecular_functionheterocyclic compound binding
G1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=M1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues156
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=M2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsSite: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues268
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues214
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues297
DetailsDomain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues280
DetailsDomain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-05-06

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