7MH1

Human CTPS2 bound to CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0003883	molecular_function	CTP synthase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006220	biological_process	pyrimidine nucleotide metabolic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0016874	molecular_function	ligase activity
H	0019637	biological_process	organophosphate metabolic process
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0097268	cellular_component	cytoophidium
J	0003883	molecular_function	CTP synthase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006220	biological_process	pyrimidine nucleotide metabolic process
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0006241	biological_process	CTP biosynthetic process
J	0006541	biological_process	glutamine metabolic process
J	0016874	molecular_function	ligase activity
J	0019637	biological_process	organophosphate metabolic process
J	0019856	biological_process	pyrimidine nucleobase biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0044210	biological_process	'de novo' CTP biosynthetic process
J	0097268	cellular_component	cytoophidium
K	0003883	molecular_function	CTP synthase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0006220	biological_process	pyrimidine nucleotide metabolic process
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006241	biological_process	CTP biosynthetic process
K	0006541	biological_process	glutamine metabolic process
K	0016874	molecular_function	ligase activity
K	0019637	biological_process	organophosphate metabolic process
K	0019856	biological_process	pyrimidine nucleobase biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0044210	biological_process	'de novo' CTP biosynthetic process
K	0097268	cellular_component	cytoophidium
L	0003883	molecular_function	CTP synthase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0006220	biological_process	pyrimidine nucleotide metabolic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006241	biological_process	CTP biosynthetic process
L	0006541	biological_process	glutamine metabolic process
L	0016874	molecular_function	ligase activity
L	0019637	biological_process	organophosphate metabolic process
L	0019856	biological_process	pyrimidine nucleobase biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0044210	biological_process	'de novo' CTP biosynthetic process
L	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605

Chain	Residue	Details
H	CYS399
L	CYS399
L	HIS526
L	GLU528
H	HIS526
H	GLU528
J	CYS399
J	HIS526
J	GLU528
K	CYS399
K	HIS526
K	GLU528

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER568
J	SER568
K	SER568
L	SER568

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER571
J	SER571
K	SER571
L	SER571

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER574
J	SER574
K	SER574
L	SER574

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