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7MFI

Bovine sigma-2 receptor bound to cholesterol

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0005764cellular_componentlysosome
A0005783cellular_componentendoplasmic reticulum
A0005791cellular_componentrough endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0008142molecular_functionoxysterol binding
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0030867cellular_componentrough endoplasmic reticulum membrane
A0031965cellular_componentnuclear membrane
A0032377biological_processregulation of intracellular lipid transport
A0032383biological_processregulation of intracellular cholesterol transport
A0042632biological_processcholesterol homeostasis
A0090303biological_processpositive regulation of wound healing
A0140077biological_processpositive regulation of lipoprotein transport
B0005634cellular_componentnucleus
B0005764cellular_componentlysosome
B0005783cellular_componentendoplasmic reticulum
B0005791cellular_componentrough endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0008142molecular_functionoxysterol binding
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0030867cellular_componentrough endoplasmic reticulum membrane
B0031965cellular_componentnuclear membrane
B0032377biological_processregulation of intracellular lipid transport
B0032383biological_processregulation of intracellular cholesterol transport
B0042632biological_processcholesterol homeostasis
B0090303biological_processpositive regulation of wound healing
B0140077biological_processpositive regulation of lipoprotein transport
C0005634cellular_componentnucleus
C0005764cellular_componentlysosome
C0005783cellular_componentendoplasmic reticulum
C0005791cellular_componentrough endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0008142molecular_functionoxysterol binding
C0015485molecular_functioncholesterol binding
C0016020cellular_componentmembrane
C0030867cellular_componentrough endoplasmic reticulum membrane
C0031965cellular_componentnuclear membrane
C0032377biological_processregulation of intracellular lipid transport
C0032383biological_processregulation of intracellular cholesterol transport
C0042632biological_processcholesterol homeostasis
C0090303biological_processpositive regulation of wound healing
C0140077biological_processpositive regulation of lipoprotein transport
D0005634cellular_componentnucleus
D0005764cellular_componentlysosome
D0005783cellular_componentendoplasmic reticulum
D0005791cellular_componentrough endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0008142molecular_functionoxysterol binding
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0030867cellular_componentrough endoplasmic reticulum membrane
D0031965cellular_componentnuclear membrane
D0032377biological_processregulation of intracellular lipid transport
D0032383biological_processregulation of intracellular cholesterol transport
D0042632biological_processcholesterol homeostasis
D0090303biological_processpositive regulation of wound healing
D0140077biological_processpositive regulation of lipoprotein transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues68
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q12155
ChainResidueDetails
AMET1-GLY9
ALYS90-PRO99
BMET1-GLY9
BLYS90-PRO99
CMET1-GLY9
CLYS90-PRO99
DMET1-GLY9
DLYS90-PRO99

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
ALEU10-LEU30
BLEU10-LEU30
CLEU10-LEU30
DLEU10-LEU30

site_idSWS_FT_FI3
Number of Residues228
DetailsTOPO_DOM: Lumenal => ECO:0000250|UniProtKB:Q12155
ChainResidueDetails
AGLN31-SER68
AASP121-LEU141
BGLN31-SER68
BASP121-LEU141
CGLN31-SER68
CASP121-LEU141
DGLN31-SER68
DASP121-LEU141

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
APHE69-PHE89
BPHE69-PHE89
CPHE69-PHE89
DPHE69-PHE89

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AALA100-LEU120
BALA100-LEU120
CALA100-LEU120
DALA100-LEU120

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
APHE142-VAL162
BPHE142-VAL162
CPHE142-VAL162
DPHE142-VAL162

site_idSWS_FT_FI7
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:34880501, ECO:0007744|PDB:7MFI
ChainResidueDetails
AVAL75
AGLN77
BVAL75
BGLN77
CVAL75
CGLN77
DVAL75
DGLN77

site_idSWS_FT_FI8
Number of Residues4
DetailsSITE: Likely important for receptor folding => ECO:0000250|UniProtKB:Q5BJF2
ChainResidueDetails
AASP56
BASP56
CASP56
DASP56

site_idSWS_FT_FI9
Number of Residues4
DetailsSITE: Important for 20(S)-OHC binding and stereoselectivity => ECO:0000250|UniProtKB:Q5BJF2
ChainResidueDetails
ATYR150
BTYR150
CTYR150
DTYR150

221051

PDB entries from 2024-06-12

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