7MFI

Bovine sigma-2 receptor bound to cholesterol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005764	cellular_component	lysosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0008142	molecular_function	oxysterol binding
A	0015485	molecular_function	cholesterol binding
A	0030867	cellular_component	rough endoplasmic reticulum membrane
A	0031965	cellular_component	nuclear membrane
A	0032377	biological_process	regulation of intracellular lipid transport
A	0032383	biological_process	regulation of intracellular cholesterol transport
A	0042632	biological_process	cholesterol homeostasis
A	0090303	biological_process	positive regulation of wound healing
A	0140077	biological_process	positive regulation of lipoprotein transport
B	0005764	cellular_component	lysosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0008142	molecular_function	oxysterol binding
B	0015485	molecular_function	cholesterol binding
B	0030867	cellular_component	rough endoplasmic reticulum membrane
B	0031965	cellular_component	nuclear membrane
B	0032377	biological_process	regulation of intracellular lipid transport
B	0032383	biological_process	regulation of intracellular cholesterol transport
B	0042632	biological_process	cholesterol homeostasis
B	0090303	biological_process	positive regulation of wound healing
B	0140077	biological_process	positive regulation of lipoprotein transport
C	0005764	cellular_component	lysosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005791	cellular_component	rough endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0008142	molecular_function	oxysterol binding
C	0015485	molecular_function	cholesterol binding
C	0030867	cellular_component	rough endoplasmic reticulum membrane
C	0031965	cellular_component	nuclear membrane
C	0032377	biological_process	regulation of intracellular lipid transport
C	0032383	biological_process	regulation of intracellular cholesterol transport
C	0042632	biological_process	cholesterol homeostasis
C	0090303	biological_process	positive regulation of wound healing
C	0140077	biological_process	positive regulation of lipoprotein transport
D	0005764	cellular_component	lysosome
D	0005783	cellular_component	endoplasmic reticulum
D	0005791	cellular_component	rough endoplasmic reticulum
D	0005886	cellular_component	plasma membrane
D	0008142	molecular_function	oxysterol binding
D	0015485	molecular_function	cholesterol binding
D	0030867	cellular_component	rough endoplasmic reticulum membrane
D	0031965	cellular_component	nuclear membrane
D	0032377	biological_process	regulation of intracellular lipid transport
D	0032383	biological_process	regulation of intracellular cholesterol transport
D	0042632	biological_process	cholesterol homeostasis
D	0090303	biological_process	positive regulation of wound healing
D	0140077	biological_process	positive regulation of lipoprotein transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	188
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"Q12155","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q12155","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34880501","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Likely important for receptor folding","evidences":[{"source":"UniProtKB","id":"Q5BJF2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Important for 20(S)-OHC binding and stereoselectivity","evidences":[{"source":"UniProtKB","id":"Q5BJF2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	296
Details	Domain: {"description":"EXPERA","evidences":[{"source":"PROSITE-ProRule","id":"PRU01087","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---