7MF3

Structure of the autoinhibited state of smooth muscle myosin-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003774	molecular_function	cytoskeletal motor activity
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005859	cellular_component	muscle myosin complex
A	0006939	biological_process	smooth muscle contraction
A	0008307	molecular_function	structural constituent of muscle
A	0016459	cellular_component	myosin complex
A	0016460	cellular_component	myosin II complex
A	0030016	cellular_component	myofibril
A	0030239	biological_process	myofibril assembly
A	0030241	biological_process	skeletal muscle myosin thick filament assembly
A	0031032	biological_process	actomyosin structure organization
A	0032027	molecular_function	myosin light chain binding
A	0032982	cellular_component	myosin filament
A	0043531	molecular_function	ADP binding
A	0045159	molecular_function	myosin II binding
A	0048251	biological_process	elastic fiber assembly
A	0051015	molecular_function	actin filament binding
A	0055013	biological_process	cardiac muscle cell development
A	0097435	biological_process	supramolecular fiber organization
A	0099512	cellular_component	supramolecular fiber
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003774	molecular_function	cytoskeletal motor activity
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005859	cellular_component	muscle myosin complex
B	0006939	biological_process	smooth muscle contraction
B	0008307	molecular_function	structural constituent of muscle
B	0016459	cellular_component	myosin complex
B	0016460	cellular_component	myosin II complex
B	0030016	cellular_component	myofibril
B	0030239	biological_process	myofibril assembly
B	0030241	biological_process	skeletal muscle myosin thick filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0032027	molecular_function	myosin light chain binding
B	0032982	cellular_component	myosin filament
B	0043531	molecular_function	ADP binding
B	0045159	molecular_function	myosin II binding
B	0048251	biological_process	elastic fiber assembly
B	0051015	molecular_function	actin filament binding
B	0055013	biological_process	cardiac muscle cell development
B	0097435	biological_process	supramolecular fiber organization
B	0099512	cellular_component	supramolecular fiber
C	0000146	molecular_function	microfilament motor activity
C	0000287	molecular_function	magnesium ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005859	cellular_component	muscle myosin complex
C	0008307	molecular_function	structural constituent of muscle
C	0016459	cellular_component	myosin complex
C	0016460	cellular_component	myosin II complex
C	0030239	biological_process	myofibril assembly
C	0031032	biological_process	actomyosin structure organization
C	0032036	molecular_function	myosin heavy chain binding
C	0042641	cellular_component	actomyosin
C	0043531	molecular_function	ADP binding
C	0045159	molecular_function	myosin II binding
C	0051015	molecular_function	actin filament binding
C	0097513	cellular_component	myosin II filament
D	0001725	cellular_component	stress fiber
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0005859	cellular_component	muscle myosin complex
D	0008307	molecular_function	structural constituent of muscle
D	0016459	cellular_component	myosin complex
D	0016460	cellular_component	myosin II complex
D	0030016	cellular_component	myofibril
D	0030239	biological_process	myofibril assembly
D	0032036	molecular_function	myosin heavy chain binding
D	0045159	molecular_function	myosin II binding
D	0046872	molecular_function	metal ion binding
E	0001725	cellular_component	stress fiber
E	0005509	molecular_function	calcium ion binding
E	0005737	cellular_component	cytoplasm
E	0005859	cellular_component	muscle myosin complex
E	0008307	molecular_function	structural constituent of muscle
E	0016459	cellular_component	myosin complex
E	0016460	cellular_component	myosin II complex
E	0030016	cellular_component	myofibril
E	0030239	biological_process	myofibril assembly
E	0032036	molecular_function	myosin heavy chain binding
E	0045159	molecular_function	myosin II binding
E	0046872	molecular_function	metal ion binding
F	0000146	molecular_function	microfilament motor activity
F	0000287	molecular_function	magnesium ion binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005859	cellular_component	muscle myosin complex
F	0008307	molecular_function	structural constituent of muscle
F	0016459	cellular_component	myosin complex
F	0016460	cellular_component	myosin II complex
F	0030239	biological_process	myofibril assembly
F	0031032	biological_process	actomyosin structure organization
F	0032036	molecular_function	myosin heavy chain binding
F	0042641	cellular_component	actomyosin
F	0043531	molecular_function	ADP binding
F	0045159	molecular_function	myosin II binding
F	0051015	molecular_function	actin filament binding
F	0097513	cellular_component	myosin II filament
G	0000146	molecular_function	microfilament motor activity
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005859	cellular_component	muscle myosin complex
G	0006939	biological_process	smooth muscle contraction
G	0008307	molecular_function	structural constituent of muscle
G	0016459	cellular_component	myosin complex
G	0016460	cellular_component	myosin II complex
G	0030016	cellular_component	myofibril
G	0030239	biological_process	myofibril assembly
G	0030241	biological_process	skeletal muscle myosin thick filament assembly
G	0031032	biological_process	actomyosin structure organization
G	0032027	molecular_function	myosin light chain binding
G	0032982	cellular_component	myosin filament
G	0043531	molecular_function	ADP binding
G	0045159	molecular_function	myosin II binding
G	0048251	biological_process	elastic fiber assembly
G	0051015	molecular_function	actin filament binding
G	0055013	biological_process	cardiac muscle cell development
G	0097435	biological_process	supramolecular fiber organization
G	0099512	cellular_component	supramolecular fiber
H	0000146	molecular_function	microfilament motor activity
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0003779	molecular_function	actin binding
H	0005515	molecular_function	protein binding
H	0005516	molecular_function	calmodulin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005859	cellular_component	muscle myosin complex
H	0006939	biological_process	smooth muscle contraction
H	0008307	molecular_function	structural constituent of muscle
H	0016459	cellular_component	myosin complex
H	0016460	cellular_component	myosin II complex
H	0030016	cellular_component	myofibril
H	0030239	biological_process	myofibril assembly
H	0030241	biological_process	skeletal muscle myosin thick filament assembly
H	0031032	biological_process	actomyosin structure organization
H	0032027	molecular_function	myosin light chain binding
H	0032982	cellular_component	myosin filament
H	0043531	molecular_function	ADP binding
H	0045159	molecular_function	myosin II binding
H	0048251	biological_process	elastic fiber assembly
H	0051015	molecular_function	actin filament binding
H	0055013	biological_process	cardiac muscle cell development
H	0097435	biological_process	supramolecular fiber organization
H	0099512	cellular_component	supramolecular fiber

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDkeDL

Chain	Residue	Details
D	ASP41-LEU53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Domain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"3312184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	134
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---