7MF3

Structure of the autoinhibited state of smooth muscle myosin-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000287	molecular_function	magnesium ion binding
A	0003774	molecular_function	cytoskeletal motor activity
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005859	cellular_component	muscle myosin complex
A	0006939	biological_process	smooth muscle contraction
A	0008307	molecular_function	structural constituent of muscle
A	0016459	cellular_component	myosin complex
A	0016460	cellular_component	myosin II complex
A	0030016	cellular_component	myofibril
A	0030239	biological_process	myofibril assembly
A	0030241	biological_process	skeletal muscle myosin thick filament assembly
A	0031032	biological_process	actomyosin structure organization
A	0032027	molecular_function	myosin light chain binding
A	0032982	cellular_component	myosin filament
A	0043531	molecular_function	ADP binding
A	0045159	molecular_function	myosin II binding
A	0048251	biological_process	elastic fiber assembly
A	0051015	molecular_function	actin filament binding
A	0055013	biological_process	cardiac muscle cell development
B	0000146	molecular_function	microfilament motor activity
B	0000287	molecular_function	magnesium ion binding
B	0003774	molecular_function	cytoskeletal motor activity
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005859	cellular_component	muscle myosin complex
B	0006939	biological_process	smooth muscle contraction
B	0008307	molecular_function	structural constituent of muscle
B	0016459	cellular_component	myosin complex
B	0016460	cellular_component	myosin II complex
B	0030016	cellular_component	myofibril
B	0030239	biological_process	myofibril assembly
B	0030241	biological_process	skeletal muscle myosin thick filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0032027	molecular_function	myosin light chain binding
B	0032982	cellular_component	myosin filament
B	0043531	molecular_function	ADP binding
B	0045159	molecular_function	myosin II binding
B	0048251	biological_process	elastic fiber assembly
B	0051015	molecular_function	actin filament binding
B	0055013	biological_process	cardiac muscle cell development
C	0000146	molecular_function	microfilament motor activity
C	0000287	molecular_function	magnesium ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005859	cellular_component	muscle myosin complex
C	0008307	molecular_function	structural constituent of muscle
C	0016459	cellular_component	myosin complex
C	0016460	cellular_component	myosin II complex
C	0030239	biological_process	myofibril assembly
C	0031032	biological_process	actomyosin structure organization
C	0032036	molecular_function	myosin heavy chain binding
C	0042641	cellular_component	actomyosin
C	0043531	molecular_function	ADP binding
C	0045159	molecular_function	myosin II binding
C	0051015	molecular_function	actin filament binding
C	0097513	cellular_component	myosin II filament
D	0001725	cellular_component	stress fiber
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0005859	cellular_component	muscle myosin complex
D	0008307	molecular_function	structural constituent of muscle
D	0016459	cellular_component	myosin complex
D	0030016	cellular_component	myofibril
D	0030239	biological_process	myofibril assembly
D	0045159	molecular_function	myosin II binding
D	0046872	molecular_function	metal ion binding
E	0001725	cellular_component	stress fiber
E	0005509	molecular_function	calcium ion binding
E	0005737	cellular_component	cytoplasm
E	0005859	cellular_component	muscle myosin complex
E	0008307	molecular_function	structural constituent of muscle
E	0016459	cellular_component	myosin complex
E	0030016	cellular_component	myofibril
E	0030239	biological_process	myofibril assembly
E	0045159	molecular_function	myosin II binding
E	0046872	molecular_function	metal ion binding
F	0000146	molecular_function	microfilament motor activity
F	0000287	molecular_function	magnesium ion binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005859	cellular_component	muscle myosin complex
F	0008307	molecular_function	structural constituent of muscle
F	0016459	cellular_component	myosin complex
F	0016460	cellular_component	myosin II complex
F	0030239	biological_process	myofibril assembly
F	0031032	biological_process	actomyosin structure organization
F	0032036	molecular_function	myosin heavy chain binding
F	0042641	cellular_component	actomyosin
F	0043531	molecular_function	ADP binding
F	0045159	molecular_function	myosin II binding
F	0051015	molecular_function	actin filament binding
F	0097513	cellular_component	myosin II filament
G	0000146	molecular_function	microfilament motor activity
G	0000287	molecular_function	magnesium ion binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005859	cellular_component	muscle myosin complex
G	0006939	biological_process	smooth muscle contraction
G	0008307	molecular_function	structural constituent of muscle
G	0016459	cellular_component	myosin complex
G	0016460	cellular_component	myosin II complex
G	0030016	cellular_component	myofibril
G	0030239	biological_process	myofibril assembly
G	0030241	biological_process	skeletal muscle myosin thick filament assembly
G	0031032	biological_process	actomyosin structure organization
G	0032027	molecular_function	myosin light chain binding
G	0032982	cellular_component	myosin filament
G	0043531	molecular_function	ADP binding
G	0045159	molecular_function	myosin II binding
G	0048251	biological_process	elastic fiber assembly
G	0051015	molecular_function	actin filament binding
G	0055013	biological_process	cardiac muscle cell development
H	0000146	molecular_function	microfilament motor activity
H	0000287	molecular_function	magnesium ion binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0003779	molecular_function	actin binding
H	0005515	molecular_function	protein binding
H	0005516	molecular_function	calmodulin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005859	cellular_component	muscle myosin complex
H	0006939	biological_process	smooth muscle contraction
H	0008307	molecular_function	structural constituent of muscle
H	0016459	cellular_component	myosin complex
H	0016460	cellular_component	myosin II complex
H	0030016	cellular_component	myofibril
H	0030239	biological_process	myofibril assembly
H	0030241	biological_process	skeletal muscle myosin thick filament assembly
H	0031032	biological_process	actomyosin structure organization
H	0032027	molecular_function	myosin light chain binding
H	0032982	cellular_component	myosin filament
H	0043531	molecular_function	ADP binding
H	0045159	molecular_function	myosin II binding
H	0048251	biological_process	elastic fiber assembly
H	0051015	molecular_function	actin filament binding
H	0055013	biological_process	cardiac muscle cell development

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDkeDL

Chain	Residue	Details
D	ASP41-LEU53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
D	ASP41
D	ASN43
D	ASP45
D	ASP52
E	ASP41
E	ASN43
E	ASP45
E	ASP52

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:6546724, ECO:0000269|PubMed:7274219

Chain	Residue	Details
D	SER1
E	SER1
G	SER2
H	SER2

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:3312184

Chain	Residue	Details
A	LYS128
B	LYS128
G	LYS128
H	LYS128

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