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7MCF

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-6-fluoro-5-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol

Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue YX4 A 301
ChainResidue
ATRP81
BTHR134
BTYR137
BILE138
BGLU154
APRO82
APHE83
ALEU92
AASN140
AILE146
AMET149
AHOH401
AHOH422

site_idAC2
Number of Residues15
Detailsbinding site for residue YX4 A 302
ChainResidue
AASN130
AGLU154
ALEU158
AILE161
AHOH419
AHOH434
BTRP81
BPRO82
BPHE83
BLEU92
BLEU94
BASN140
BILE146
BMET149
BHOH404

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

223532

PDB entries from 2024-08-07

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