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7MCA

Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003688molecular_functionDNA replication origin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005656cellular_componentnuclear pre-replicative complex
A0005664cellular_componentnuclear origin of replication recognition complex
A0005694cellular_componentchromosome
A0006260biological_processDNA replication
A0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
A0006270biological_processDNA replication initiation
A0016887molecular_functionATP hydrolysis activity
A0030466biological_processsilent mating-type cassette heterochromatin formation
A0031261cellular_componentDNA replication preinitiation complex
A0031491molecular_functionnucleosome binding
A0033314biological_processmitotic DNA replication checkpoint signaling
A0034728biological_processnucleosome organization
A0043007biological_processmaintenance of rDNA
A0046872molecular_functionmetal ion binding
B0000781cellular_componentchromosome, telomeric region
B0000808cellular_componentorigin recognition complex
B0003682molecular_functionchromatin binding
B0003688molecular_functionDNA replication origin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005656cellular_componentnuclear pre-replicative complex
B0005664cellular_componentnuclear origin of replication recognition complex
B0006260biological_processDNA replication
B0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
B0006270biological_processDNA replication initiation
B0030466biological_processsilent mating-type cassette heterochromatin formation
B0031261cellular_componentDNA replication preinitiation complex
B0031509biological_processsubtelomeric heterochromatin formation
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003688molecular_functionDNA replication origin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005656cellular_componentnuclear pre-replicative complex
C0005664cellular_componentnuclear origin of replication recognition complex
C0006260biological_processDNA replication
C0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
C0006270biological_processDNA replication initiation
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0031261cellular_componentDNA replication preinitiation complex
D0000808cellular_componentorigin recognition complex
D0003677molecular_functionDNA binding
D0003688molecular_functionDNA replication origin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005656cellular_componentnuclear pre-replicative complex
D0005664cellular_componentnuclear origin of replication recognition complex
D0006260biological_processDNA replication
D0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
D0006270biological_processDNA replication initiation
D0030466biological_processsilent mating-type cassette heterochromatin formation
D0031261cellular_componentDNA replication preinitiation complex
E0000808cellular_componentorigin recognition complex
E0003688molecular_functionDNA replication origin binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005656cellular_componentnuclear pre-replicative complex
E0005664cellular_componentnuclear origin of replication recognition complex
E0006260biological_processDNA replication
E0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
E0006270biological_processDNA replication initiation
E0006275biological_processregulation of DNA replication
E0030466biological_processsilent mating-type cassette heterochromatin formation
E0031261cellular_componentDNA replication preinitiation complex
E0035361cellular_componentCul8-RING ubiquitin ligase complex
F0003677molecular_functionDNA binding
F0003688molecular_functionDNA replication origin binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005656cellular_componentnuclear pre-replicative complex
F0005664cellular_componentnuclear origin of replication recognition complex
F0006260biological_processDNA replication
F0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
F0006270biological_processDNA replication initiation
F0030466biological_processsilent mating-type cassette heterochromatin formation
F0031261cellular_componentDNA replication preinitiation complex
I0000082biological_processG1/S transition of mitotic cell cycle
I0003682molecular_functionchromatin binding
I0003688molecular_functionDNA replication origin binding
I0003924molecular_functionGTPase activity
I0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005656cellular_componentnuclear pre-replicative complex
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0006260biological_processDNA replication
I0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
I0006270biological_processDNA replication initiation
I0016887molecular_functionATP hydrolysis activity
I0030174biological_processregulation of DNA-templated DNA replication initiation
I0031261cellular_componentDNA replication preinitiation complex
I0033314biological_processmitotic DNA replication checkpoint signaling
I0051301biological_processcell division
I0140530biological_processMCM complex loading
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNQSKKMNvsEF
ChainResidueDetails
CASP3-PHE15

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
IGLY108
BTHR187
AASP566
AGLU567
AASN600
AARG704

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ITHR368

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER237

227111

PDB entries from 2024-11-06

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