Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7MBF

codeinone reductase isoform 1.3 Apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009820	biological_process	alkaloid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0047036	molecular_function	codeinone reductase (NADPH) activity
A	0071272	biological_process	morphine metabolic process
A	2001291	biological_process	codeine metabolic process
B	0004032	molecular_function	aldose reductase (NADPH) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009820	biological_process	alkaloid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0047036	molecular_function	codeinone reductase (NADPH) activity
B	0071272	biological_process	morphine metabolic process
B	2001291	biological_process	codeine metabolic process
C	0004032	molecular_function	aldose reductase (NADPH) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009820	biological_process	alkaloid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0047036	molecular_function	codeinone reductase (NADPH) activity
C	0071272	biological_process	morphine metabolic process
C	2001291	biological_process	codeine metabolic process
D	0004032	molecular_function	aldose reductase (NADPH) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009820	biological_process	alkaloid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0047036	molecular_function	codeinone reductase (NADPH) activity
D	0071272	biological_process	morphine metabolic process
D	2001291	biological_process	codeine metabolic process
E	0004032	molecular_function	aldose reductase (NADPH) activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009820	biological_process	alkaloid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0047036	molecular_function	codeinone reductase (NADPH) activity
E	0071272	biological_process	morphine metabolic process
E	2001291	biological_process	codeine metabolic process
F	0004032	molecular_function	aldose reductase (NADPH) activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009820	biological_process	alkaloid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0047036	molecular_function	codeinone reductase (NADPH) activity
F	0071272	biological_process	morphine metabolic process
F	2001291	biological_process	codeine metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeecqtlgfTRAIGVCNF

Chain	Residue	Details
A	MET150-PHE167

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. VVKSFNegRMkENlKI

Chain	Residue	Details
A	VAL261-ILE276

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDTAaayqsEecLG

Chain	Residue	Details
A	GLY46-GLY63

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000250\|UniProtKB:P06632

Chain	Residue	Details
A	TYR56
B	TYR56
C	TYR56
D	TYR56
E	TYR56
F	TYR56

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000250\|UniProtKB:Q76L36

Chain	Residue	Details
B	HIS119
C	HIS119
D	HIS119
E	HIS119
F	HIS119
A	HIS119

site_id	SWS_FT_FI3
Number of Residues	42
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q76L36

Chain	Residue	Details
A	ARG269
B	THR27
B	ASP51
B	GLN187
B	SER214
B	LEU216
B	SER264
B	ARG269
C	THR27
C	ASP51
C	GLN187
C	SER214
C	LEU216
C	SER264
C	ARG269
D	THR27
D	ASP51
D	GLN187
D	SER214
D	LEU216
D	SER264
D	ARG269
E	THR27
E	ASP51
E	GLN187
E	SER214
E	LEU216
E	SER264
E	ARG269
F	THR27
F	ASP51
F	GLN187
F	SER214
F	LEU216
F	SER264
F	ARG269
A	GLN187
A	SER214
A	LEU216
A	SER264
A	ASP51
A	THR27

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P06632

Chain	Residue	Details
A	HIS119
B	HIS119
C	HIS119
D	HIS119
E	HIS119
F	HIS119

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Lowers pKa of active site Tyr => ECO:0000250\|UniProtKB:Q76L36

Chain	Residue	Details
A	LYS86
B	LYS86
C	LYS86
D	LYS86
E	LYS86
F	LYS86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)