7MBF

codeinone reductase isoform 1.3 Apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0009820	biological_process	alkaloid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0047036	molecular_function	codeinone reductase (NADPH) activity
A	0071272	biological_process	morphine metabolic process
A	2001291	biological_process	codeine metabolic process
B	0005829	cellular_component	cytosol
B	0009820	biological_process	alkaloid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0047036	molecular_function	codeinone reductase (NADPH) activity
B	0071272	biological_process	morphine metabolic process
B	2001291	biological_process	codeine metabolic process
C	0005829	cellular_component	cytosol
C	0009820	biological_process	alkaloid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0047036	molecular_function	codeinone reductase (NADPH) activity
C	0071272	biological_process	morphine metabolic process
C	2001291	biological_process	codeine metabolic process
D	0005829	cellular_component	cytosol
D	0009820	biological_process	alkaloid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0047036	molecular_function	codeinone reductase (NADPH) activity
D	0071272	biological_process	morphine metabolic process
D	2001291	biological_process	codeine metabolic process
E	0005829	cellular_component	cytosol
E	0009820	biological_process	alkaloid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0047036	molecular_function	codeinone reductase (NADPH) activity
E	0071272	biological_process	morphine metabolic process
E	2001291	biological_process	codeine metabolic process
F	0005829	cellular_component	cytosol
F	0009820	biological_process	alkaloid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0047036	molecular_function	codeinone reductase (NADPH) activity
F	0071272	biological_process	morphine metabolic process
F	2001291	biological_process	codeine metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeecqtlgfTRAIGVCNF

Chain	Residue	Details
A	MET150-PHE167

---

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. VVKSFNegRMkENlKI

Chain	Residue	Details
A	VAL261-ILE276

---

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDTAaayqsEecLG

Chain	Residue	Details
A	GLY46-GLY63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P06632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q76L36","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q76L36","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P06632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"Q76L36","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---