7M8Q

Complex structure of Methane monooxygenase hydroxylase and regulatory subunit with fluorosubstituted tryptophans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0006730	biological_process	one-carbon metabolic process
A	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
C	0004497	molecular_function	monooxygenase activity
C	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
C	0015947	biological_process	methane metabolic process
D	0004497	molecular_function	monooxygenase activity
E	0004497	molecular_function	monooxygenase activity
E	0006730	biological_process	one-carbon metabolic process
E	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
E	0046872	molecular_function	metal ion binding
F	0004497	molecular_function	monooxygenase activity
F	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
G	0004497	molecular_function	monooxygenase activity
G	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
G	0015947	biological_process	methane metabolic process
H	0004497	molecular_function	monooxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue FE A 801

Chain	Residue
A	GLU114
A	GLU144
A	HIS147
A	FE802
A	BEZ803
A	HOH1243
A	HOH1269

---

site_id	AC2
Number of Residues	7
Details	binding site for residue FE A 802

Chain	Residue
A	GLU243
A	HIS246
A	FE801
A	BEZ803
A	HOH1243
A	GLU144
A	GLU209

---

site_id	AC3
Number of Residues	11
Details	binding site for residue BEZ A 803

Chain	Residue
A	GLU114
A	GLU144
A	PHE188
A	GLY208
A	GLU209
A	THR213
A	GLU243
A	FE801
A	FE802
A	HOH1243
A	HOH1269

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 804

Chain	Residue
A	GLY357
A	PHE358
A	ALA359
A	HOH1357

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 805

Chain	Residue
A	ARG476
A	GLU480
A	HOH1323
A	HOH1364
C	PRO6

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO B 401

Chain	Residue
A	PHE79
B	GLU51

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO B 402

Chain	Residue
B	ARG121
B	ARG125

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO B 403

Chain	Residue
A	GLN406
B	TYR304
B	ASN308
B	HOH520

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO C 201

Chain	Residue
C	ARG4
C	ILE12
C	ASP49
C	ILE50
C	ASP51
C	VAL52
C	ASP53
C	HOH365

---

site_id	AD1
Number of Residues	7
Details	binding site for residue FE E 801

Chain	Residue
E	GLU114
E	GLU144
E	HIS147
E	FE802
E	BEZ803
E	HOH928
E	HOH978

---

site_id	AD2
Number of Residues	7
Details	binding site for residue FE E 802

Chain	Residue
E	GLU144
E	GLU209
E	GLU243
E	HIS246
E	FE801
E	BEZ803
E	HOH978

---

site_id	AD3
Number of Residues	11
Details	binding site for residue BEZ E 803

Chain	Residue
E	GLU114
E	GLU144
E	PHE188
E	GLY208
E	GLU209
E	THR213
E	GLU243
E	FE801
E	FE802
E	HOH928
E	HOH978

---

site_id	AD4
Number of Residues	10
Details	binding site for residue EDO E 804

Chain	Residue
E	ASN273
E	GLN456
E	GLU460
E	ARG463
E	TYR464
E	HOH911
E	HOH950
E	HOH1138
E	HOH1198
G	TYR148

---

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO E 805

Chain	Residue
E	ASN54
E	ALA128
E	THR129
E	ALA130
E	GLN133
E	TYR137
E	THR253
E	HOH903

---

site_id	AD6
Number of Residues	3
Details	binding site for residue NA E 806

Chain	Residue
E	HIS51
E	HOH1296
E	HOH1324

---

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO F 401

Chain	Residue
D	LYS97
F	GLU51

---

site_id	AD8
Number of Residues	8
Details	binding site for residue EDO G 201

Chain	Residue
G	ILE12
G	ASP49
G	ILE50
G	ASP51
G	VAL52
G	ASP53
G	HOH310
G	ARG4

---

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO H 201

Chain	Residue
A	ARG88
F	ARG12
H	LYS44
H	ALA73
H	HOH306
H	HOH320

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	CYS151
E	CYS151

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU114
E	GLU209
E	GLU243
E	HIS246
A	GLU144
A	HIS147
A	GLU209
A	GLU243
A	HIS246
E	GLU114
E	GLU144
E	HIS147

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 600

Chain	Residue	Details
A	GLU114	metal ligand
A	GLU144	metal ligand
A	HIS147	metal ligand
A	GLU209	metal ligand
A	GLU243	hydrogen bond donor, metal ligand
A	HIS246	metal ligand

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 600

Chain	Residue	Details
E	GLU114	metal ligand
E	GLU144	metal ligand
E	HIS147	metal ligand
E	GLU209	metal ligand
E	GLU243	hydrogen bond donor, metal ligand
E	HIS246	metal ligand

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