7M6P

Full length alpha1 Glycine receptor in presence of 1mM Glycine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0016020	cellular_component	membrane
A	0016594	molecular_function	glycine binding
A	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
A	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0016020	cellular_component	membrane
B	0016594	molecular_function	glycine binding
B	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
B	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0016020	cellular_component	membrane
C	0016594	molecular_function	glycine binding
C	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
C	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0016020	cellular_component	membrane
D	0016594	molecular_function	glycine binding
D	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
D	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006821	biological_process	chloride transport
E	0016020	cellular_component	membrane
E	0016594	molecular_function	glycine binding
E	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
E	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC

Chain	Residue	Details
A	CYS162-CYS176

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1205
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	ALA25-TYR246
D	ALA25-TYR246
D	ARG295-LYS305
D	LYS434-GLN444
E	ALA25-TYR246
E	ARG295-LYS305
E	LYS434-GLN444
A	ARG295-LYS305
A	LYS434-GLN444
B	ALA25-TYR246
B	ARG295-LYS305
B	LYS434-GLN444
C	ALA25-TYR246
C	ARG295-LYS305
C	LYS434-GLN444

---

site_id	SWS_FT_FI2
Number of Residues	105
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	TYR247-ILE268
B	TYR247-ILE268
C	TYR247-ILE268
D	TYR247-ILE268
E	TYR247-ILE268

---

site_id	SWS_FT_FI3
Number of Residues	445
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	ASN269-ALA273
E	ALA327-THR412
A	ALA327-THR412
B	ASN269-ALA273
B	ALA327-THR412
C	ASN269-ALA273
C	ALA327-THR412
D	ASN269-ALA273
D	ALA327-THR412
E	ASN269-ALA273

---

site_id	SWS_FT_FI4
Number of Residues	100
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	PRO274-SER294
B	PRO274-SER294
C	PRO274-SER294
D	PRO274-SER294
E	PRO274-SER294

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	ALA306-ALA326
B	ALA306-ALA326
C	ALA306-ALA326
D	ALA306-ALA326
E	ALA306-ALA326

---

site_id	SWS_FT_FI6
Number of Residues	100
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	VAL413-TYR433
B	VAL413-TYR433
C	VAL413-TYR433
D	VAL413-TYR433
E	VAL413-TYR433

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P23415

Chain	Residue	Details
A	GLU216
D	GLU216
D	ASP218
D	HIS239
E	GLU216
E	ASP218
E	HIS239
A	ASP218
A	HIS239
B	GLU216
B	ASP218
B	HIS239
C	GLU216
C	ASP218
C	HIS239

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	TYR226
B	TYR226
C	TYR226
D	TYR226
E	TYR226

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	LEU285
B	LEU285
C	LEU285
D	LEU285
E	LEU285

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26344198

Chain	Residue	Details
A	ASN62
B	ASN62
C	ASN62
D	ASN62
E	ASN62

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