7M4P
Multidrug Efflux pump AdeJ with Eravacycline bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue 3PE A 1101 |
| Chain | Residue |
| A | SER447 |
| A | LEU896 |
| C | PHE11 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue 3PE B 1101 |
| Chain | Residue |
| B | TRP900 |
| B | SER901 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 3PE B 1102 |
| Chain | Residue |
| B | THR450 |
| B | ILE472 |
| B | CYS892 |
| B | LEU896 |
| A | ARG8 |
| B | VAL443 |
| B | GLY444 |
| B | SER447 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue 3PE B 1103 |
| Chain | Residue |
| B | TRP13 |
| B | THR495 |
| C | TRP900 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue 3PE B 1104 |
| Chain | Residue |
| B | SER874 |
| B | TYR882 |
| B | SER885 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue YQM B 1105 |
| Chain | Residue |
| B | PHE136 |
| B | GLY179 |
| B | TYR327 |
| B | VAL613 |
| B | PHE629 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue 3PE C 1101 |
| Chain | Residue |
| C | SER899 |
| C | TRP900 |
| C | SER901 |
| C | PHE904 |
| C | PHE1044 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE C 1102 |
| Chain | Residue |
| C | PHE558 |
| C | PRO879 |
| C | TYR882 |
| C | LEU907 |
| C | VAL910 |
| C | ASN935 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue 3PE C 1103 |
| Chain | Residue |
| C | TRP13 |
| C | LEU27 |
| C | VAL341 |
| C | PHE352 |
| C | PRO373 |
| C | VAL376 |
| C | PHE380 |
