7M3X
Crystal Structure of the Apo Form of Human RBBP7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000118 | cellular_component | histone deacetylase complex |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0007420 | biological_process | brain development |
| A | 0016581 | cellular_component | NuRD complex |
| A | 0016589 | cellular_component | NURF complex |
| A | 0030308 | biological_process | negative regulation of cell growth |
| A | 0030336 | biological_process | negative regulation of cell migration |
| A | 0030512 | biological_process | negative regulation of transforming growth factor beta receptor signaling pathway |
| A | 0035098 | cellular_component | ESC/E(Z) complex |
| A | 0042393 | molecular_function | histone binding |
| A | 0042659 | biological_process | regulation of cell fate specification |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0048545 | biological_process | response to steroid hormone |
| A | 0070370 | biological_process | cellular heat acclimation |
| A | 0070822 | cellular_component | Sin3-type complex |
| A | 1902455 | biological_process | negative regulation of stem cell population maintenance |
| A | 1902459 | biological_process | positive regulation of stem cell population maintenance |
| A | 1904949 | cellular_component | ATPase complex |
| A | 2000736 | biological_process | regulation of stem cell differentiation |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTVCLWDI |
| Chain | Residue | Details |
| A | LEU192-ILE206 | |
| A | LEU288-LEU302 | |
| A | LEU332-LEU346 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER95 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q60973 |
| Chain | Residue | Details |
| A | LYS119 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60973 |
| Chain | Residue | Details |
| A | LYS159 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER354 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS101 | |
| A | LYS155 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS159 |
