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7M1S

Crystal structure of human guanylate-binding protein 2 (hGBP2) K51A mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0003924molecular_functionGTPase activity
A0004866molecular_functionendopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006955biological_processimmune response
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0034504biological_processprotein localization to nucleus
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042832biological_processdefense response to protozoan
A0045087biological_processinnate immune response
A0046718biological_processsymbiont entry into host cell
A0048471cellular_componentperinuclear region of cytoplasm
A0050830biological_processdefense response to Gram-positive bacterium
A0051604biological_processprotein maturation
A0051607biological_processdefense response to virus
A0051715biological_processcytolysis in another organism
A0071222biological_processcellular response to lipopolysaccharide
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0140678molecular_functionmolecular function inhibitor activity
A0140973biological_processpositive regulation of AIM2 inflammasome complex assembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q96PP8
ChainResidueDetails
AGLY45
AARG181
ALEU245

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000305|PubMed:21151871
ChainResidueDetails
ACYS588

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:21151871, ECO:0000305|PubMed:31091448
ChainResidueDetails
ACYS588

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PDB entries from 2025-06-11

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