7M1S

Crystal structure of human guanylate-binding protein 2 (hGBP2) K51A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006955	biological_process	immune response
A	0016787	molecular_function	hydrolase activity
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0034504	biological_process	protein localization to nucleus
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051607	biological_process	defense response to virus
A	0051715	biological_process	cytolysis in another organism
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071346	biological_process	cellular response to type II interferon
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
A	0140678	molecular_function	molecular function inhibitor activity
A	0140973	biological_process	positive regulation of AIM2 inflammasome complex assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	241
Details	Domain: {"description":"GB1/RHD3-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01052","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96PP8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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