7LZB

Crystal Structure of SETD2 bound to Compound 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0046975	molecular_function	histone H3K36 methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625, ECO:0007744|PDB:4FMU, ECO:0007744|PDB:4H12, ECO:0007744|PDB:5JJY, ECO:0007744|PDB:5JLB, ECO:0007744|PDB:5JLE, ECO:0007744|PDB:5V21, ECO:0007744|PDB:5V22

Chain	Residue	Details
A	CYS1520
A	CYS1529
A	CYS1533
A	CYS1539
A	CYS1631
A	CYS1678
A	CYS1680
A	CYS1685
A	CYS1499
A	CYS1501
A	CYS1516

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625, ECO:0007744|PDB:4H12, ECO:0007744|PDB:5JJY, ECO:0007744|PDB:5JLB, ECO:0007744|PDB:5JLE, ECO:0007744|PDB:5V22

Chain	Residue	Details
A	PHE1679
A	LYS1560
A	HIS1603
A	ASN1628
A	GLN1676

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1696

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