7LXB

HeLa-tubulin in complex with cryptophycin 52

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030182	biological_process	neuron differentiation
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0051301	biological_process	cell division
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005929	cellular_component	cilium
B	0007017	biological_process	microtubule-based process
B	0007411	biological_process	axon guidance
B	0015630	cellular_component	microtubule cytoskeleton
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030182	biological_process	neuron differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0038007	biological_process	netrin-activated signaling pathway
B	0042277	molecular_function	peptide binding
B	0043025	cellular_component	neuronal cell body
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0072686	cellular_component	mitotic spindle
B	0097228	cellular_component	sperm principal piece
B	0097229	cellular_component	sperm end piece
B	0097542	cellular_component	ciliary tip
B	1990791	biological_process	dorsal root ganglion development
B	1990890	molecular_function	netrin receptor binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003725	molecular_function	double-stranded RNA binding
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030182	biological_process	neuron differentiation
C	0030705	biological_process	cytoskeleton-dependent intracellular transport
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0051301	biological_process	cell division
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005929	cellular_component	cilium
D	0007017	biological_process	microtubule-based process
D	0007411	biological_process	axon guidance
D	0015630	cellular_component	microtubule cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030182	biological_process	neuron differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0038007	biological_process	netrin-activated signaling pathway
D	0042277	molecular_function	peptide binding
D	0043025	cellular_component	neuronal cell body
D	0045171	cellular_component	intercellular bridge
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0072686	cellular_component	mitotic spindle
D	0097228	cellular_component	sperm principal piece
D	0097229	cellular_component	sperm end piece
D	0097542	cellular_component	ciliary tip
D	1990791	biological_process	dorsal root ganglion development
D	1990890	molecular_function	netrin receptor binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003725	molecular_function	double-stranded RNA binding
E	0003924	molecular_function	GTPase activity
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005929	cellular_component	cilium
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0030182	biological_process	neuron differentiation
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0051301	biological_process	cell division
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005929	cellular_component	cilium
F	0007017	biological_process	microtubule-based process
F	0007411	biological_process	axon guidance
F	0015630	cellular_component	microtubule cytoskeleton
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030182	biological_process	neuron differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0038007	biological_process	netrin-activated signaling pathway
F	0042277	molecular_function	peptide binding
F	0043025	cellular_component	neuronal cell body
F	0045171	cellular_component	intercellular bridge
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071944	cellular_component	cell periphery
F	0072686	cellular_component	mitotic spindle
F	0097228	cellular_component	sperm principal piece
F	0097229	cellular_component	sperm end piece
F	0097542	cellular_component	ciliary tip
F	1990791	biological_process	dorsal root ganglion development
F	1990890	molecular_function	netrin receptor binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003725	molecular_function	double-stranded RNA binding
G	0003924	molecular_function	GTPase activity
G	0005198	molecular_function	structural molecule activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005929	cellular_component	cilium
G	0007017	biological_process	microtubule-based process
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0030182	biological_process	neuron differentiation
G	0030705	biological_process	cytoskeleton-dependent intracellular transport
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0051301	biological_process	cell division
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0007411	biological_process	axon guidance
H	0015630	cellular_component	microtubule cytoskeleton
H	0030027	cellular_component	lamellipodium
H	0030175	cellular_component	filopodium
H	0030182	biological_process	neuron differentiation
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0030426	cellular_component	growth cone
H	0038007	biological_process	netrin-activated signaling pathway
H	0042277	molecular_function	peptide binding
H	0043025	cellular_component	neuronal cell body
H	0045171	cellular_component	intercellular bridge
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0071944	cellular_component	cell periphery
H	0072686	cellular_component	mitotic spindle
H	0097228	cellular_component	sperm principal piece
H	0097229	cellular_component	sperm end piece
H	0097542	cellular_component	ciliary tip
H	1990791	biological_process	dorsal root ganglion development
H	1990890	molecular_function	netrin receptor binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003725	molecular_function	double-stranded RNA binding
I	0003924	molecular_function	GTPase activity
I	0005198	molecular_function	structural molecule activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005881	cellular_component	cytoplasmic microtubule
I	0005929	cellular_component	cilium
I	0007017	biological_process	microtubule-based process
I	0015630	cellular_component	microtubule cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0030182	biological_process	neuron differentiation
I	0030705	biological_process	cytoskeleton-dependent intracellular transport
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0051301	biological_process	cell division
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005929	cellular_component	cilium
J	0007017	biological_process	microtubule-based process
J	0007411	biological_process	axon guidance
J	0015630	cellular_component	microtubule cytoskeleton
J	0030027	cellular_component	lamellipodium
J	0030175	cellular_component	filopodium
J	0030182	biological_process	neuron differentiation
J	0030424	cellular_component	axon
J	0030425	cellular_component	dendrite
J	0030426	cellular_component	growth cone
J	0038007	biological_process	netrin-activated signaling pathway
J	0042277	molecular_function	peptide binding
J	0043025	cellular_component	neuronal cell body
J	0045171	cellular_component	intercellular bridge
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	0071944	cellular_component	cell periphery
J	0072686	cellular_component	mitotic spindle
J	0097228	cellular_component	sperm principal piece
J	0097229	cellular_component	sperm end piece
J	0097542	cellular_component	ciliary tip
J	1990791	biological_process	dorsal root ganglion development
J	1990890	molecular_function	netrin receptor binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003725	molecular_function	double-stranded RNA binding
K	0003924	molecular_function	GTPase activity
K	0005198	molecular_function	structural molecule activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0005929	cellular_component	cilium
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0030182	biological_process	neuron differentiation
K	0030705	biological_process	cytoskeleton-dependent intracellular transport
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0051301	biological_process	cell division
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0005929	cellular_component	cilium
L	0007017	biological_process	microtubule-based process
L	0007411	biological_process	axon guidance
L	0015630	cellular_component	microtubule cytoskeleton
L	0030027	cellular_component	lamellipodium
L	0030175	cellular_component	filopodium
L	0030182	biological_process	neuron differentiation
L	0030424	cellular_component	axon
L	0030425	cellular_component	dendrite
L	0030426	cellular_component	growth cone
L	0038007	biological_process	netrin-activated signaling pathway
L	0042277	molecular_function	peptide binding
L	0043025	cellular_component	neuronal cell body
L	0045171	cellular_component	intercellular bridge
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	0071944	cellular_component	cell periphery
L	0072686	cellular_component	mitotic spindle
L	0097228	cellular_component	sperm principal piece
L	0097229	cellular_component	sperm end piece
L	0097542	cellular_component	ciliary tip
L	1990791	biological_process	dorsal root ganglion development
L	1990890	molecular_function	netrin receptor binding
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0003725	molecular_function	double-stranded RNA binding
M	0003924	molecular_function	GTPase activity
M	0005198	molecular_function	structural molecule activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0005881	cellular_component	cytoplasmic microtubule
M	0005929	cellular_component	cilium
M	0007017	biological_process	microtubule-based process
M	0015630	cellular_component	microtubule cytoskeleton
M	0016787	molecular_function	hydrolase activity
M	0030182	biological_process	neuron differentiation
M	0030705	biological_process	cytoskeleton-dependent intracellular transport
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0051301	biological_process	cell division
N	0000166	molecular_function	nucleotide binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0005929	cellular_component	cilium
N	0007017	biological_process	microtubule-based process
N	0007411	biological_process	axon guidance
N	0015630	cellular_component	microtubule cytoskeleton
N	0030027	cellular_component	lamellipodium
N	0030175	cellular_component	filopodium
N	0030182	biological_process	neuron differentiation
N	0030424	cellular_component	axon
N	0030425	cellular_component	dendrite
N	0030426	cellular_component	growth cone
N	0038007	biological_process	netrin-activated signaling pathway
N	0042277	molecular_function	peptide binding
N	0043025	cellular_component	neuronal cell body
N	0045171	cellular_component	intercellular bridge
N	0046872	molecular_function	metal ion binding
N	0070062	cellular_component	extracellular exosome
N	0071944	cellular_component	cell periphery
N	0072686	cellular_component	mitotic spindle
N	0097228	cellular_component	sperm principal piece
N	0097229	cellular_component	sperm end piece
N	0097542	cellular_component	ciliary tip
N	1990791	biological_process	dorsal root ganglion development
N	1990890	molecular_function	netrin receptor binding
O	0000166	molecular_function	nucleotide binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0003725	molecular_function	double-stranded RNA binding
O	0003924	molecular_function	GTPase activity
O	0005198	molecular_function	structural molecule activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0005881	cellular_component	cytoplasmic microtubule
O	0005929	cellular_component	cilium
O	0007017	biological_process	microtubule-based process
O	0015630	cellular_component	microtubule cytoskeleton
O	0016787	molecular_function	hydrolase activity
O	0030182	biological_process	neuron differentiation
O	0030705	biological_process	cytoskeleton-dependent intracellular transport
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0051301	biological_process	cell division
P	0000166	molecular_function	nucleotide binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0005929	cellular_component	cilium
P	0007017	biological_process	microtubule-based process
P	0007411	biological_process	axon guidance
P	0015630	cellular_component	microtubule cytoskeleton
P	0030027	cellular_component	lamellipodium
P	0030175	cellular_component	filopodium
P	0030182	biological_process	neuron differentiation
P	0030424	cellular_component	axon
P	0030425	cellular_component	dendrite
P	0030426	cellular_component	growth cone
P	0038007	biological_process	netrin-activated signaling pathway
P	0042277	molecular_function	peptide binding
P	0043025	cellular_component	neuronal cell body
P	0045171	cellular_component	intercellular bridge
P	0046872	molecular_function	metal ion binding
P	0070062	cellular_component	extracellular exosome
P	0071944	cellular_component	cell periphery
P	0072686	cellular_component	mitotic spindle
P	0097228	cellular_component	sperm principal piece
P	0097229	cellular_component	sperm end piece
P	0097542	cellular_component	ciliary tip
P	1990791	biological_process	dorsal root ganglion development
P	1990890	molecular_function	netrin receptor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue GTP A 601

Chain	Residue
A	GLY10
A	THR145
A	GLY146
A	THR179
A	GLU183
A	ASN206
A	TYR224
A	GLN11
A	ALA12
A	GLN15
A	ASP69
A	ASP98
A	GLY142
A	GLY143
A	GLY144

---

site_id	AC2
Number of Residues	15
Details	binding site for residue YGY B 1201

Chain	Residue
A	THR257
A	ASN258
A	PRO261
A	MET313
A	ALA314
A	CYS347
A	LYS352
B	ASN99
B	ASN100
B	LYS103
B	THR178
B	VAL179
B	VAL180
B	PHE394
B	TRP397

---

site_id	AC3
Number of Residues	15
Details	binding site for residue GDP B 1202

Chain	Residue
B	CYS12
B	GLN15
B	GLU69
B	ALA97
B	GLY140
B	GLY141
B	GLY142
B	THR143
B	VAL169
B	PRO171
B	VAL175
B	GLU181
B	ASN204
B	TYR222
B	ASN226

---

site_id	AC4
Number of Residues	15
Details	binding site for residue GTP C 601

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP69
C	ASP98
C	GLY142
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	THR179
C	GLU183
C	ASN206
C	TYR224

---

site_id	AC5
Number of Residues	15
Details	binding site for residue YGY D 1201

Chain	Residue
C	THR257
C	ASN258
C	PRO261
C	MET313
C	ALA314
C	CYS347
C	LYS352
D	ASN99
D	ASN100
D	LYS103
D	THR178
D	VAL179
D	VAL180
D	PHE394
D	TRP397

---

site_id	AC6
Number of Residues	15
Details	binding site for residue GDP D 1202

Chain	Residue
D	CYS12
D	GLN15
D	GLU69
D	ALA97
D	GLY140
D	GLY141
D	GLY142
D	THR143
D	VAL169
D	PRO171
D	VAL175
D	GLU181
D	ASN204
D	TYR222
D	ASN226

---

site_id	AC7
Number of Residues	15
Details	binding site for residue GTP E 601

Chain	Residue
E	THR145
E	GLY146
E	THR179
E	GLU183
E	ASN206
E	TYR224
E	GLY10
E	GLN11
E	ALA12
E	GLN15
E	ASP69
E	ASP98
E	GLY142
E	GLY143
E	GLY144

---

site_id	AC8
Number of Residues	15
Details	binding site for residue YGY F 1201

Chain	Residue
E	THR257
E	ASN258
E	PRO261
E	MET313
E	ALA314
E	CYS347
E	LYS352
F	ASN99
F	ASN100
F	LYS103
F	THR178
F	VAL179
F	VAL180
F	PHE394
F	TRP397

---

site_id	AC9
Number of Residues	15
Details	binding site for residue GDP F 1202

Chain	Residue
F	CYS12
F	GLN15
F	GLU69
F	ALA97
F	GLY140
F	GLY141
F	GLY142
F	THR143
F	VAL169
F	PRO171
F	VAL175
F	GLU181
F	ASN204
F	TYR222
F	ASN226

---

site_id	AD1
Number of Residues	15
Details	binding site for residue GTP G 601

Chain	Residue
G	GLY10
G	GLN11
G	ALA12
G	GLN15
G	ASP69
G	ASP98
G	GLY142
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	THR179
G	GLU183
G	ASN206
G	TYR224

---

site_id	AD2
Number of Residues	15
Details	binding site for residue YGY H 1201

Chain	Residue
G	THR257
G	ASN258
G	PRO261
G	MET313
G	ALA314
G	CYS347
G	LYS352
H	ASN99
H	ASN100
H	LYS103
H	THR178
H	VAL179
H	VAL180
H	PHE394
H	TRP397

---

site_id	AD3
Number of Residues	15
Details	binding site for residue GDP H 1202

Chain	Residue
H	CYS12
H	GLN15
H	GLU69
H	ALA97
H	GLY140
H	GLY141
H	GLY142
H	THR143
H	VAL169
H	PRO171
H	VAL175
H	GLU181
H	ASN204
H	TYR222
H	ASN226

---

site_id	AD4
Number of Residues	15
Details	binding site for residue GTP I 601

Chain	Residue
I	GLY10
I	GLN11
I	ALA12
I	GLN15
I	ASP69
I	ASP98
I	GLY142
I	GLY143
I	GLY144
I	THR145
I	GLY146
I	THR179
I	GLU183
I	ASN206
I	TYR224

---

site_id	AD5
Number of Residues	15
Details	binding site for residue YGY J 1201

Chain	Residue
I	THR257
I	ASN258
I	PRO261
I	MET313
I	ALA314
I	CYS347
I	LYS352
J	ASN99
J	ASN100
J	LYS103
J	THR178
J	VAL179
J	VAL180
J	PHE394
J	TRP397

---

site_id	AD6
Number of Residues	15
Details	binding site for residue GDP J 1202

Chain	Residue
J	CYS12
J	GLN15
J	GLU69
J	ALA97
J	GLY140
J	GLY141
J	GLY142
J	THR143
J	VAL169
J	PRO171
J	VAL175
J	GLU181
J	ASN204
J	TYR222
J	ASN226

---

site_id	AD7
Number of Residues	15
Details	binding site for residue GTP K 601

Chain	Residue
K	GLY10
K	GLN11
K	ALA12
K	GLN15
K	ASP69
K	ASP98
K	GLY142
K	GLY143
K	GLY144
K	THR145
K	GLY146
K	THR179
K	GLU183
K	ASN206
K	TYR224

---

site_id	AD8
Number of Residues	15
Details	binding site for residue YGY L 1201

Chain	Residue
K	THR257
K	ASN258
K	PRO261
K	MET313
K	ALA314
K	CYS347
K	LYS352
L	ASN99
L	ASN100
L	LYS103
L	THR178
L	VAL179
L	VAL180
L	PHE394
L	TRP397

---

site_id	AD9
Number of Residues	15
Details	binding site for residue GDP L 1202

Chain	Residue
L	CYS12
L	GLN15
L	GLU69
L	ALA97
L	GLY140
L	GLY141
L	GLY142
L	THR143
L	VAL169
L	PRO171
L	VAL175
L	GLU181
L	ASN204
L	TYR222
L	ASN226

---

site_id	AE1
Number of Residues	15
Details	binding site for residue GTP M 601

Chain	Residue
M	GLY10
M	GLN11
M	ALA12
M	GLN15
M	ASP69
M	ASP98
M	GLY142
M	GLY143
M	GLY144
M	THR145
M	GLY146
M	THR179
M	GLU183
M	ASN206
M	TYR224

---

site_id	AE2
Number of Residues	15
Details	binding site for residue YGY N 1201

Chain	Residue
M	THR257
M	ASN258
M	PRO261
M	MET313
M	ALA314
M	CYS347
M	LYS352
N	ASN99
N	ASN100
N	LYS103
N	THR178
N	VAL179
N	VAL180
N	PHE394
N	TRP397

---

site_id	AE3
Number of Residues	15
Details	binding site for residue GDP N 1202

Chain	Residue
N	CYS12
N	GLN15
N	GLU69
N	ALA97
N	GLY140
N	GLY141
N	GLY142
N	THR143
N	VAL169
N	PRO171
N	VAL175
N	GLU181
N	ASN204
N	TYR222
N	ASN226

---

site_id	AE4
Number of Residues	15
Details	binding site for residue GTP O 601

Chain	Residue
O	GLY10
O	GLN11
O	ALA12
O	GLN15
O	ASP69
O	ASP98
O	GLY142
O	GLY143
O	GLY144
O	THR145
O	GLY146
O	THR179
O	GLU183
O	ASN206
O	TYR224

---

site_id	AE5
Number of Residues	15
Details	binding site for residue YGY P 1201

Chain	Residue
O	THR257
O	ASN258
O	PRO261
O	MET313
O	ALA314
O	CYS347
O	LYS352
P	ASN99
P	ASN100
P	LYS103
P	THR178
P	VAL179
P	VAL180
P	PHE394
P	TRP397

---

site_id	AE6
Number of Residues	15
Details	binding site for residue GDP P 1202

Chain	Residue
P	CYS12
P	GLN15
P	GLU69
P	ALA97
P	GLY140
P	GLY141
P	GLY142
P	THR143
P	VAL169
P	PRO171
P	VAL175
P	GLU181
P	ASN204
P	TYR222
P	ASN226

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY140-GLY146

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"24906155","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---