7LRL

Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935))

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006699	biological_process	bile acid biosynthetic process
A	0006707	biological_process	cholesterol catabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0007399	biological_process	nervous system development
A	0008203	biological_process	cholesterol metabolic process
A	0008207	biological_process	C21-steroid hormone metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016020	cellular_component	membrane
A	0016125	biological_process	sterol metabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0030425	cellular_component	dendrite
A	0033781	molecular_function	cholesterol 24-hydroxylase activity
A	0042448	biological_process	progesterone metabolic process
A	0042995	cellular_component	cell projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0062184	molecular_function	testosterone 16-beta-hydroxylase activity
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	1900271	biological_process	regulation of long-term synaptic potentiation
A	1903044	biological_process	protein localization to membrane raft

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGHRSCIG

Chain	Residue	Details
A	PHE430-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828, ECO:0000269|PubMed:23288837, ECO:0007744|PDB:2Q9F, ECO:0007744|PDB:2Q9G, ECO:0007744|PDB:3MDR, ECO:0007744|PDB:3MDT, ECO:0007744|PDB:3MDV, ECO:0007744|PDB:4ENH, ECO:0007744|PDB:4FIA, ECO:0007744|PDB:4J14

Chain	Residue	Details
A	CYS437

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