7LMB

Tetrahymena telomerase T5D5 structure at 3.8 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000333	cellular_component	telomerase catalytic core complex
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003720	molecular_function	telomerase activity
A	0003723	molecular_function	RNA binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005697	cellular_component	telomerase holoenzyme complex
A	0007004	biological_process	telomere maintenance via telomerase
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
A	0042162	molecular_function	telomeric DNA binding
A	0046872	molecular_function	metal ion binding
A	0070034	molecular_function	telomerase RNA binding
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0005697	cellular_component	telomerase holoenzyme complex
D	0007004	biological_process	telomere maintenance via telomerase
D	0008270	molecular_function	zinc ion binding
D	0043047	molecular_function	single-stranded telomeric DNA binding
D	0046872	molecular_function	metal ion binding
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0005662	cellular_component	DNA replication factor A complex
E	0005697	cellular_component	telomerase holoenzyme complex
F	0000781	cellular_component	chromosome, telomeric region
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0005662	cellular_component	DNA replication factor A complex
F	0005697	cellular_component	telomerase holoenzyme complex
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0031981	cellular_component	nuclear lumen
G	0000781	cellular_component	chromosome, telomeric region
G	0005697	cellular_component	telomerase holoenzyme complex
G	0007004	biological_process	telomere maintenance via telomerase
H	0000781	cellular_component	chromosome, telomeric region
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0005697	cellular_component	telomerase holoenzyme complex
H	0007004	biological_process	telomere maintenance via telomerase
H	0070034	molecular_function	telomerase RNA binding
H	0090669	biological_process	telomerase RNA stabilization
H	1904868	biological_process	telomerase catalytic core complex assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20713447","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22143754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U50","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	DNA binding: {"description":"OB","evidences":[{"source":"UniProtKB","id":"P15927","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---