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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7LJD

Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001588molecular_functiondopamine neurotransmitter receptor activity, coupled via Gs
R0001659biological_processtemperature homeostasis
R0001661biological_processconditioned taste aversion
R0001662biological_processbehavioral fear response
R0001764biological_processneuron migration
R0001963biological_processsynaptic transmission, dopaminergic
R0001965molecular_functionG-protein alpha-subunit binding
R0001975biological_processresponse to amphetamine
R0004930molecular_functionG protein-coupled receptor activity
R0004952molecular_functiondopamine neurotransmitter receptor activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005783cellular_componentendoplasmic reticulum
R0005789cellular_componentendoplasmic reticulum membrane
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0006606biological_processprotein import into nucleus
R0006936biological_processmuscle contraction
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
R0007212biological_processG protein-coupled dopamine receptor signaling pathway
R0007416biological_processsynapse assembly
R0007612biological_processlearning
R0007613biological_processmemory
R0007617biological_processmating behavior
R0007625biological_processgrooming behavior
R0007626biological_processlocomotory behavior
R0007628biological_processadult walking behavior
R0007631biological_processfeeding behavior
R0008306biological_processassociative learning
R0008542biological_processvisual learning
R0009410biological_processresponse to xenobiotic stimulus
R0012505cellular_componentendomembrane system
R0014002biological_processastrocyte development
R0015872biological_processdopamine transport
R0016020cellular_componentmembrane
R0016477biological_processcell migration
R0019226biological_processtransmission of nerve impulse
R0019228biological_processneuronal action potential
R0021542biological_processdentate gyrus development
R0021756biological_processstriatum development
R0021766biological_processhippocampus development
R0021853biological_processcerebral cortex GABAergic interneuron migration
R0030335biological_processpositive regulation of cell migration
R0030425cellular_componentdendrite
R0030432biological_processperistalsis
R0032795molecular_functionheterotrimeric G-protein binding
R0035106biological_processoperant conditioning
R0035240molecular_functiondopamine binding
R0035249biological_processsynaptic transmission, glutamatergic
R0042053biological_processregulation of dopamine metabolic process
R0042220biological_processresponse to cocaine
R0042311biological_processvasodilation
R0042417biological_processdopamine metabolic process
R0042711biological_processmaternal behavior
R0042734cellular_componentpresynaptic membrane
R0043197cellular_componentdendritic spine
R0043268biological_processpositive regulation of potassium ion transport
R0043410biological_processpositive regulation of MAPK cascade
R0045211cellular_componentpostsynaptic membrane
R0046323biological_processD-glucose import
R0046959biological_processhabituation
R0046960biological_processsensitization
R0048148biological_processbehavioral response to cocaine
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0051584biological_processregulation of dopamine uptake involved in synaptic transmission
R0051968biological_processpositive regulation of synaptic transmission, glutamatergic
R0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
R0060170cellular_componentciliary membrane
R0060291biological_processlong-term synaptic potentiation
R0060292biological_processlong-term synaptic depression
R0071870biological_processcellular response to catecholamine stimulus
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0097648cellular_componentG protein-coupled receptor complex
R0097730cellular_componentnon-motile cilium
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099010biological_processmodification of postsynaptic structure
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R1990763molecular_functionarrestin family protein binding
R2001224biological_processpositive regulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCVISVDRYWaI
ChainResidueDetails
RALA109-ILE125
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues28
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"10618483","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues13
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues5
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues17
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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