7LI8
apo serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in inward open conformation
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
site_id | PS00610 |
Number of Residues | 15 |
Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYicyqNGGGaF |
Chain | Residue | Details |
A | TRP103-PHE117 |
site_id | PS00754 |
Number of Residues | 21 |
Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLisSFTdqLPWtsCknswNT |
Chain | Residue | Details |
A | TYR186-THR206 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | PHE88-ASN112 |
site_id | SWS_FT_FI2 |
Number of Residues | 158 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
A | GLY113-GLY115 | |
A | LEU187-SER252 | |
A | ARG298-GLY324 | |
A | THR381-THR421 | |
A | GLY484-GLU494 | |
A | SER559-SER574 |
site_id | SWS_FT_FI3 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ALA116-MET135 |
site_id | SWS_FT_FI4 |
Number of Residues | 81 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | GLU136-GLY160 | |
A | LYS272-SER277 | |
A | ALA348-ASP360 | |
A | GLU444-GLU463 | |
A | GLY517-ARG538 |
site_id | SWS_FT_FI5 |
Number of Residues | 25 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ILE161-TYR186 |
site_id | SWS_FT_FI6 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | TRP253-TRP271 |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | GLY278-VAL297 |
site_id | SWS_FT_FI8 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | VAL325-PHE347 |
site_id | SWS_FT_FI9 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ALA361-PHE380 |
site_id | SWS_FT_FI10 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | PHE422-LEU443 |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ARG464-PHE483 |
site_id | SWS_FT_FI12 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | TYR495-TYR516 |
site_id | SWS_FT_FI13 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ILE539-MET558 |
site_id | SWS_FT_FI14 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ILE575-TYR595 |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6, ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
Chain | Residue | Details |
A | GLY94 | |
A | VAL97 | |
A | ASP437 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000305|PubMed:27049939, ECO:0000312|PDB:7LIA, ECO:0007744|PDB:5I6X |
Chain | Residue | Details |
A | ALA96 | |
A | SER336 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7MGW |
Chain | Residue | Details |
A | ASP98 | |
A | GLU494 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:27049939, ECO:0007744|PDB:5I6X |
Chain | Residue | Details |
A | ASN101 | |
A | ASN368 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
Chain | Residue | Details |
A | LEU434 | |
A | SER438 |
site_id | SWS_FT_FI20 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA, ECO:0000312|PDB:7MGW |
Chain | Residue | Details |
A | THR439 | |
A | PHE556 | |
A | SER559 |
site_id | SWS_FT_FI21 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
Chain | Residue | Details |
A | TYR495 |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21992875 |
Chain | Residue | Details |
A | TYR142 |
site_id | SWS_FT_FI23 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by PKG => ECO:0000269|PubMed:17913921 |
Chain | Residue | Details |
A | THR276 |
site_id | SWS_FT_FI24 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27049939 |
Chain | Residue | Details |
A | ASN208 | |
A | ASN217 |