Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7LHF

Structure of full-length IP3R1 channel solubilized in LNMG & lipid in the apo-state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001666biological_processresponse to hypoxia
A0005216molecular_functionmonoatomic ion channel activity
A0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005637cellular_componentnuclear inner membrane
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005955cellular_componentcalcineurin complex
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006915biological_processapoptotic process
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007338biological_processsingle fertilization
A0009791biological_processpost-embryonic development
A0010976biological_processpositive regulation of neuron projection development
A0014069cellular_componentpostsynaptic density
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016358biological_processdendrite development
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0019903molecular_functionprotein phosphatase binding
A0019904molecular_functionprotein domain specific binding
A0030425cellular_componentdendrite
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0030868cellular_componentsmooth endoplasmic reticulum membrane
A0031088cellular_componentplatelet dense granule membrane
A0031094cellular_componentplatelet dense tubular network
A0031410cellular_componentcytoplasmic vesicle
A0032024biological_processpositive regulation of insulin secretion
A0032469biological_processendoplasmic reticulum calcium ion homeostasis
A0032991cellular_componentprotein-containing complex
A0035091molecular_functionphosphatidylinositol binding
A0036444biological_processcalcium import into the mitochondrion
A0042045biological_processepithelial fluid transport
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050849biological_processnegative regulation of calcium-mediated signaling
A0050882biological_processvoluntary musculoskeletal movement
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051928biological_processpositive regulation of calcium ion transport
A0055085biological_processtransmembrane transport
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0097060cellular_componentsynaptic membrane
A0097421biological_processliver regeneration
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098982cellular_componentGABA-ergic synapse
A0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
A0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
A1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
A1990806biological_processligand-gated ion channel signaling pathway
A2000347biological_processpositive regulation of hepatocyte proliferation
B0000902biological_processcell morphogenesis
B0001666biological_processresponse to hypoxia
B0005216molecular_functionmonoatomic ion channel activity
B0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005635cellular_componentnuclear envelope
B0005637cellular_componentnuclear inner membrane
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006915biological_processapoptotic process
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
B0007338biological_processsingle fertilization
B0009791biological_processpost-embryonic development
B0010976biological_processpositive regulation of neuron projection development
B0014069cellular_componentpostsynaptic density
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016358biological_processdendrite development
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019855molecular_functioncalcium channel inhibitor activity
B0019903molecular_functionprotein phosphatase binding
B0019904molecular_functionprotein domain specific binding
B0030425cellular_componentdendrite
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0030868cellular_componentsmooth endoplasmic reticulum membrane
B0031088cellular_componentplatelet dense granule membrane
B0031094cellular_componentplatelet dense tubular network
B0031410cellular_componentcytoplasmic vesicle
B0032024biological_processpositive regulation of insulin secretion
B0032469biological_processendoplasmic reticulum calcium ion homeostasis
B0032991cellular_componentprotein-containing complex
B0035091molecular_functionphosphatidylinositol binding
B0036444biological_processcalcium import into the mitochondrion
B0042045biological_processepithelial fluid transport
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050849biological_processnegative regulation of calcium-mediated signaling
B0050882biological_processvoluntary musculoskeletal movement
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051928biological_processpositive regulation of calcium ion transport
B0055085biological_processtransmembrane transport
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0071320biological_processcellular response to cAMP
B0071456biological_processcellular response to hypoxia
B0097060cellular_componentsynaptic membrane
B0097421biological_processliver regeneration
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
B0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
B1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
B1990806biological_processligand-gated ion channel signaling pathway
B2000347biological_processpositive regulation of hepatocyte proliferation
C0000902biological_processcell morphogenesis
C0001666biological_processresponse to hypoxia
C0005216molecular_functionmonoatomic ion channel activity
C0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005637cellular_componentnuclear inner membrane
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005955cellular_componentcalcineurin complex
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006915biological_processapoptotic process
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
C0007338biological_processsingle fertilization
C0009791biological_processpost-embryonic development
C0010976biological_processpositive regulation of neuron projection development
C0014069cellular_componentpostsynaptic density
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016358biological_processdendrite development
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019855molecular_functioncalcium channel inhibitor activity
C0019903molecular_functionprotein phosphatase binding
C0019904molecular_functionprotein domain specific binding
C0030425cellular_componentdendrite
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0030868cellular_componentsmooth endoplasmic reticulum membrane
C0031088cellular_componentplatelet dense granule membrane
C0031094cellular_componentplatelet dense tubular network
C0031410cellular_componentcytoplasmic vesicle
C0032024biological_processpositive regulation of insulin secretion
C0032469biological_processendoplasmic reticulum calcium ion homeostasis
C0032991cellular_componentprotein-containing complex
C0035091molecular_functionphosphatidylinositol binding
C0036444biological_processcalcium import into the mitochondrion
C0042045biological_processepithelial fluid transport
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050849biological_processnegative regulation of calcium-mediated signaling
C0050882biological_processvoluntary musculoskeletal movement
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051928biological_processpositive regulation of calcium ion transport
C0055085biological_processtransmembrane transport
C0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0071320biological_processcellular response to cAMP
C0071456biological_processcellular response to hypoxia
C0097060cellular_componentsynaptic membrane
C0097421biological_processliver regeneration
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098982cellular_componentGABA-ergic synapse
C0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
C0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
C1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
C1990806biological_processligand-gated ion channel signaling pathway
C2000347biological_processpositive regulation of hepatocyte proliferation
D0000902biological_processcell morphogenesis
D0001666biological_processresponse to hypoxia
D0005216molecular_functionmonoatomic ion channel activity
D0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005635cellular_componentnuclear envelope
D0005637cellular_componentnuclear inner membrane
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006915biological_processapoptotic process
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
D0007338biological_processsingle fertilization
D0009791biological_processpost-embryonic development
D0010976biological_processpositive regulation of neuron projection development
D0014069cellular_componentpostsynaptic density
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016358biological_processdendrite development
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019855molecular_functioncalcium channel inhibitor activity
D0019903molecular_functionprotein phosphatase binding
D0019904molecular_functionprotein domain specific binding
D0030425cellular_componentdendrite
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0030868cellular_componentsmooth endoplasmic reticulum membrane
D0031088cellular_componentplatelet dense granule membrane
D0031094cellular_componentplatelet dense tubular network
D0031410cellular_componentcytoplasmic vesicle
D0032024biological_processpositive regulation of insulin secretion
D0032469biological_processendoplasmic reticulum calcium ion homeostasis
D0032991cellular_componentprotein-containing complex
D0035091molecular_functionphosphatidylinositol binding
D0036444biological_processcalcium import into the mitochondrion
D0042045biological_processepithelial fluid transport
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050849biological_processnegative regulation of calcium-mediated signaling
D0050882biological_processvoluntary musculoskeletal movement
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051928biological_processpositive regulation of calcium ion transport
D0055085biological_processtransmembrane transport
D0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0071320biological_processcellular response to cAMP
D0071456biological_processcellular response to hypoxia
D0097060cellular_componentsynaptic membrane
D0097421biological_processliver regeneration
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098695molecular_functioninositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098982cellular_componentGABA-ergic synapse
D0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
D0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
D1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
D1990806biological_processligand-gated ion channel signaling pathway
D2000347biological_processpositive regulation of hepatocyte proliferation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255, ECO:0000305|PubMed:10506212
ChainResidueDetails
APHE2275-TYR2295
DTYR2398-PHE2418
DILE2441-LEU2461
DASP2570-ILE2590
BPHE2275-TYR2295
BPRO2307-LEU2327
BLEU2354-GLY2374
BTYR2398-PHE2418
BILE2441-LEU2461
BASP2570-ILE2590
CPHE2275-TYR2295
APRO2307-LEU2327
CPRO2307-LEU2327
CLEU2354-GLY2374
CTYR2398-PHE2418
CILE2441-LEU2461
CASP2570-ILE2590
ALEU2354-GLY2374
ATYR2398-PHE2418
AILE2441-LEU2461
AASP2570-ILE2590
DPHE2275-TYR2295
DPRO2307-LEU2327
DLEU2354-GLY2374

site_idSWS_FT_FI2
Number of Residues556
DetailsTOPO_DOM: Lumenal => ECO:0000255, ECO:0000269|PubMed:10506212
ChainResidueDetails
APRO2296-GLU2306
CPRO2296-GLU2306
CASN2375-LEU2397
CPHE2462-TYR2569
AASN2375-LEU2397
APHE2462-TYR2569
DPRO2296-GLU2306
DASN2375-LEU2397
DPHE2462-TYR2569
BPRO2296-GLU2306
BASN2375-LEU2397
BPHE2462-TYR2569

site_idSWS_FT_FI3
Number of Residues184
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255, ECO:0000269|PubMed:10506212
ChainResidueDetails
APRO2328-THR2353
AASP2419-PRO2440
DPRO2328-THR2353
DASP2419-PRO2440
BPRO2328-THR2353
BASP2419-PRO2440
CPRO2328-THR2353
CASP2419-PRO2440

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:21892169, ECO:0000269|PubMed:22286060, ECO:0000269|PubMed:36376291, ECO:0007744|PDB:3T8S, ECO:0007744|PDB:3UJ0, ECO:0007744|PDB:8EAR
ChainResidueDetails
AARG265
ATYR567
DARG265
DTYR567
BARG265
BTYR567
CARG265
CTYR567

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:21892169, ECO:0000269|PubMed:22286060, ECO:0007744|PDB:3T8S, ECO:0007744|PDB:3UJ0
ChainResidueDetails
ATHR267
CTHR267
CARG511
CARG568
AARG511
AARG568
DTHR267
DARG511
DARG568
BTHR267
BARG511
BARG568

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:22286060, ECO:0007744|PDB:3UJ0
ChainResidueDetails
AGLY268
AARG269
DGLY268
DARG269
BGLY268
BARG269
CGLY268
CARG269

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P11881
ChainResidueDetails
ALYS508
DLYS508
BLYS508
CLYS508

site_idSWS_FT_FI8
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:36376291, ECO:0007744|PDB:8EAR
ChainResidueDetails
ALYS2221
DASN2583
DCYS2611
DPHE2612
DHIS2636
DMET2638
BLYS2221
BLYS2224
BASN2583
BCYS2611
BPHE2612
ALYS2224
BHIS2636
BMET2638
CLYS2221
CLYS2224
CASN2583
CCYS2611
CPHE2612
CHIS2636
CMET2638
AASN2583
ACYS2611
APHE2612
AHIS2636
AMET2638
DLYS2221
DLYS2224

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12939273, ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER1589
DSER1589
BSER1589
CSER1589

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:12939273, ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER1756
DSER1756
BSER1756
CSER1756

site_idSWS_FT_FI11
Number of Residues8
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P11881
ChainResidueDetails
ACYS56
ACYS849
DCYS56
DCYS849
BCYS56
BCYS849
CCYS56
CCYS849

site_idSWS_FT_FI12
Number of Residues48
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18955483
ChainResidueDetails
ALYS916
ALYS1925
ALYS2119
ALYS2258
DLYS916
DLYS962
DLYS1572
DLYS1772
DLYS1885
DLYS1886
DLYS1887
DLYS1902
DLYS1925
DLYS2119
DLYS2258
BLYS916
BLYS962
BLYS1572
BLYS1772
ALYS962
BLYS1885
BLYS1886
BLYS1887
BLYS1902
BLYS1925
BLYS2119
BLYS2258
CLYS916
CLYS962
ALYS1572
CLYS1572
CLYS1772
CLYS1885
CLYS1886
CLYS1887
CLYS1902
CLYS1925
CLYS2119
CLYS2258
ALYS1772
ALYS1885
ALYS1886
ALYS1887
ALYS1902

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon