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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7LH3

Structure of human prestin in the presence of sodium sulfate

Functional Information from GO Data
ChainGOidnamespacecontents
A0002931biological_processresponse to ischemia
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006821biological_processchloride transport
A0007605biological_processsensory perception of sound
A0008271molecular_functionsecondary active sulfate transmembrane transporter activity
A0008360biological_processregulation of cell shape
A0009410biological_processresponse to xenobiotic stimulus
A0009751biological_processresponse to salicylic acid
A0010996biological_processresponse to auditory stimulus
A0015116molecular_functionsulfate transmembrane transporter activity
A0015701biological_processbicarbonate transport
A0015755biological_processfructose transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016328cellular_componentlateral plasma membrane
A0019531molecular_functionoxalate transmembrane transporter activity
A0019532biological_processoxalate transport
A0030507molecular_functionspectrin binding
A0034220biological_processmonoatomic ion transmembrane transport
A0034766biological_processnegative regulation of monoatomic ion transmembrane transport
A0035864biological_processresponse to potassium ion
A0042391biological_processregulation of membrane potential
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045793biological_processpositive regulation of cell size
A0055085biological_processtransmembrane transport
A0090102biological_processcochlea development
A0097066biological_processresponse to thyroid hormone
A0098656biological_processmonoatomic anion transmembrane transport
A0120249cellular_componentlateral wall of outer hair cell
A0140900molecular_functionchloride:bicarbonate antiporter activity
A1902074biological_processresponse to salt
A1902358biological_processsulfate transmembrane transport
A1902476biological_processchloride transmembrane transport
A2000147biological_processpositive regulation of cell motility
B0002931biological_processresponse to ischemia
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006821biological_processchloride transport
B0007605biological_processsensory perception of sound
B0008271molecular_functionsecondary active sulfate transmembrane transporter activity
B0008360biological_processregulation of cell shape
B0009410biological_processresponse to xenobiotic stimulus
B0009751biological_processresponse to salicylic acid
B0010996biological_processresponse to auditory stimulus
B0015116molecular_functionsulfate transmembrane transporter activity
B0015701biological_processbicarbonate transport
B0015755biological_processfructose transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019531molecular_functionoxalate transmembrane transporter activity
B0019532biological_processoxalate transport
B0030507molecular_functionspectrin binding
B0034220biological_processmonoatomic ion transmembrane transport
B0034766biological_processnegative regulation of monoatomic ion transmembrane transport
B0035864biological_processresponse to potassium ion
B0042391biological_processregulation of membrane potential
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045793biological_processpositive regulation of cell size
B0055085biological_processtransmembrane transport
B0090102biological_processcochlea development
B0097066biological_processresponse to thyroid hormone
B0098656biological_processmonoatomic anion transmembrane transport
B0120249cellular_componentlateral wall of outer hair cell
B0140900molecular_functionchloride:bicarbonate antiporter activity
B1902074biological_processresponse to salt
B1902358biological_processsulfate transmembrane transport
B1902476biological_processchloride transmembrane transport
B2000147biological_processpositive regulation of cell motility
Functional Information from PROSITE/UniProt
site_idPS01130
Number of Residues22
DetailsSLC26A SLC26A transporters signature. PiFGLYSSfypvIMYcflGTSR
ChainResidueDetails
APRO109-ARG130
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues58
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues134
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues66
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=5a","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsIntramembrane: {"description":"Helical; Name=5b","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues30
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues30
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsMotif: {"description":"Involved in motor function","evidences":[{"source":"UniProtKB","id":"Q9JKQ2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsSite: {"description":"Controls the electromotile activity","evidences":[{"source":"UniProtKB","id":"A0FKN5","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q9EPH0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsSite: {"description":"Contributes to anion binding","evidences":[{"source":"UniProtKB","id":"Q9EPH0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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