7LH2
Structure of human prestin in the presence of sodium salicylate and sodium sulfate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002931 | biological_process | response to ischemia |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006821 | biological_process | chloride transport |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008271 | molecular_function | secondary active sulfate transmembrane transporter activity |
| A | 0008272 | biological_process | sulfate transport |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009751 | biological_process | response to salicylic acid |
| A | 0010996 | biological_process | response to auditory stimulus |
| A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015116 | molecular_function | sulfate transmembrane transporter activity |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0015755 | biological_process | fructose transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0019531 | molecular_function | oxalate transmembrane transporter activity |
| A | 0019532 | biological_process | oxalate transport |
| A | 0030507 | molecular_function | spectrin binding |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
| A | 0035864 | biological_process | response to potassium ion |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045793 | biological_process | positive regulation of cell size |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0090102 | biological_process | cochlea development |
| A | 0097066 | biological_process | response to thyroid hormone |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0120249 | cellular_component | lateral wall of outer hair cell |
| A | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| A | 1902074 | biological_process | response to salt |
| A | 1902358 | biological_process | sulfate transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 2000147 | biological_process | positive regulation of cell motility |
| B | 0002931 | biological_process | response to ischemia |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006821 | biological_process | chloride transport |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0008271 | molecular_function | secondary active sulfate transmembrane transporter activity |
| B | 0008272 | biological_process | sulfate transport |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009751 | biological_process | response to salicylic acid |
| B | 0010996 | biological_process | response to auditory stimulus |
| B | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015116 | molecular_function | sulfate transmembrane transporter activity |
| B | 0015701 | biological_process | bicarbonate transport |
| B | 0015755 | biological_process | fructose transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0019531 | molecular_function | oxalate transmembrane transporter activity |
| B | 0019532 | biological_process | oxalate transport |
| B | 0030507 | molecular_function | spectrin binding |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
| B | 0035864 | biological_process | response to potassium ion |
| B | 0042391 | biological_process | regulation of membrane potential |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045793 | biological_process | positive regulation of cell size |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0090102 | biological_process | cochlea development |
| B | 0097066 | biological_process | response to thyroid hormone |
| B | 0098656 | biological_process | monoatomic anion transmembrane transport |
| B | 0120249 | cellular_component | lateral wall of outer hair cell |
| B | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| B | 1902074 | biological_process | response to salt |
| B | 1902358 | biological_process | sulfate transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 2000147 | biological_process | positive regulation of cell motility |
Functional Information from PROSITE/UniProt
| site_id | PS01130 |
| Number of Residues | 22 |
| Details | SLC26A SLC26A transporters signature. PiFGLYSSfypvIMYcflGTSR |
| Chain | Residue | Details |
| A | PRO109-ARG130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 692 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-LYS75 | |
| B | GLY127-PHE137 | |
| B | ARG197-THR206 | |
| B | LYS283-PRO291 | |
| B | GLN368-ASP370 | |
| B | GLY407-THR410 | |
| B | SER465 | |
| B | SER505-ALA744 | |
| A | GLY127-PHE137 | |
| A | ARG197-THR206 | |
| A | LYS283-PRO291 | |
| A | GLN368-ASP370 | |
| A | GLY407-THR410 | |
| A | SER465 | |
| A | SER505-ALA744 | |
| B | MET1-LYS75 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | PHE76-ALA105 | |
| B | PHE76-ALA105 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 134 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA106-PRO108 | |
| B | VAL152-THR168 | |
| B | GLY231-PHE241 | |
| B | VAL254-ASN258 | |
| B | ASN308-ASP332 | |
| B | GLN389-SER396 | |
| B | GLU433-PRO436 | |
| B | LEU482-GLY483 | |
| A | VAL152-THR168 | |
| A | GLY231-PHE241 | |
| A | VAL254-ASN258 | |
| A | ASN308-ASP332 | |
| A | GLN389-SER396 | |
| A | GLU433-PRO436 | |
| A | LEU482-GLY483 | |
| B | ALA106-PRO108 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | PRO109-LEU126 | |
| B | PRO109-LEU126 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | ALA138-LEU151 | |
| B | ALA138-LEU151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | GLU169-CYS196 | |
| B | GLU169-CYS196 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=5a => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | GLU207-PHE230 | |
| B | GLU207-PHE230 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | INTRAMEM: Helical; Name=5b => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | SER242-ASN253 | |
| B | SER242-ASN253 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | VAL259-PHE282 | |
| B | VAL259-PHE282 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | LEU292-PHE307 | |
| B | LEU292-PHE307 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 68 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | THR333-TYR367 | |
| B | THR333-TYR367 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | GLY371-PHE388 | |
| B | GLY371-PHE388 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | LEU397-THR406 | |
| B | LEU397-THR406 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | GLN411-PHE432 | |
| B | GLN411-PHE432 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | GLN437-THR464 | |
| B | GLN437-THR464 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | LYS466-PHE481 | |
| B | LYS466-PHE481 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LGU, ECO:0007744|PDB:7LGW, ECO:0007744|PDB:7LH2, ECO:0007744|PDB:7LH3 |
| Chain | Residue | Details |
| A | LEU484-GLN504 | |
| B | LEU484-GLN504 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34390643, ECO:0007744|PDB:7LH2 |
| Chain | Residue | Details |
| A | SER398 | |
| B | SER398 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | SITE: Controls the electromotile activity => ECO:0000250|UniProtKB:A0FKN5, ECO:0000250|UniProtKB:Q9EPH0 |
| Chain | Residue | Details |
| A | SER398 | |
| B | SER398 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | SITE: Contributes to anion binding => ECO:0000250|UniProtKB:Q9EPH0 |
| Chain | Residue | Details |
| A | ARG399 | |
| B | ARG399 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN163 | |
| A | ASN166 | |
| B | ASN163 | |
| B | ASN166 |
