Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7LGW

Structure of human Prestin in nanodisc in the presence of NaCl

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002931	biological_process	response to ischemia
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006821	biological_process	chloride transport
A	0007605	biological_process	sensory perception of sound
A	0008271	molecular_function	secondary active sulfate transmembrane transporter activity
A	0008360	biological_process	regulation of cell shape
A	0009410	biological_process	response to xenobiotic stimulus
A	0009751	biological_process	response to salicylic acid
A	0010996	biological_process	response to auditory stimulus
A	0015116	molecular_function	sulfate transmembrane transporter activity
A	0015701	biological_process	bicarbonate transport
A	0015755	biological_process	fructose transmembrane transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016328	cellular_component	lateral plasma membrane
A	0019531	molecular_function	oxalate transmembrane transporter activity
A	0019532	biological_process	oxalate transport
A	0030507	molecular_function	spectrin binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
A	0035864	biological_process	response to potassium ion
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045793	biological_process	positive regulation of cell size
A	0055085	biological_process	transmembrane transport
A	0090102	biological_process	cochlea development
A	0097066	biological_process	response to thyroid hormone
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0120249	cellular_component	lateral wall of outer hair cell
A	0140900	molecular_function	chloride:bicarbonate antiporter activity
A	1902074	biological_process	response to salt
A	1902358	biological_process	sulfate transmembrane transport
A	1902476	biological_process	chloride transmembrane transport
A	2000147	biological_process	positive regulation of cell motility
B	0002931	biological_process	response to ischemia
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006821	biological_process	chloride transport
B	0007605	biological_process	sensory perception of sound
B	0008271	molecular_function	secondary active sulfate transmembrane transporter activity
B	0008360	biological_process	regulation of cell shape
B	0009410	biological_process	response to xenobiotic stimulus
B	0009751	biological_process	response to salicylic acid
B	0010996	biological_process	response to auditory stimulus
B	0015116	molecular_function	sulfate transmembrane transporter activity
B	0015701	biological_process	bicarbonate transport
B	0015755	biological_process	fructose transmembrane transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016328	cellular_component	lateral plasma membrane
B	0019531	molecular_function	oxalate transmembrane transporter activity
B	0019532	biological_process	oxalate transport
B	0030507	molecular_function	spectrin binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035864	biological_process	response to potassium ion
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0045793	biological_process	positive regulation of cell size
B	0055085	biological_process	transmembrane transport
B	0090102	biological_process	cochlea development
B	0097066	biological_process	response to thyroid hormone
B	0098656	biological_process	monoatomic anion transmembrane transport
B	0120249	cellular_component	lateral wall of outer hair cell
B	0140900	molecular_function	chloride:bicarbonate antiporter activity
B	1902074	biological_process	response to salt
B	1902358	biological_process	sulfate transmembrane transport
B	1902476	biological_process	chloride transmembrane transport
B	2000147	biological_process	positive regulation of cell motility

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 801

Chain	Residue
A	PHE137
A	SER396

site_id	AC2
Number of Residues	5
Details	binding site for residue CLR A 802

Chain	Residue
A	TYR486
A	ILE493
A	ILE494
A	D10807
B	CLR802

site_id	AC3
Number of Residues	1
Details	binding site for residue OCT A 804

Chain	Residue
A	TYR204

site_id	AC4
Number of Residues	2
Details	binding site for residue OCT A 805

Chain	Residue
A	D10816
A	OCT806

site_id	AC5
Number of Residues	1
Details	binding site for residue OCT A 806

Chain	Residue
A	OCT805

site_id	AC6
Number of Residues	1
Details	binding site for residue D10 A 807

Chain	Residue
A	CLR802

site_id	AC7
Number of Residues	1
Details	binding site for residue OCT A 808

Chain	Residue
A	TYR245

site_id	AC8
Number of Residues	1
Details	binding site for residue OCT A 809

Chain	Residue
A	PHE241

site_id	AC9
Number of Residues	1
Details	binding site for residue D12 A 810

Chain	Residue
A	D12839

site_id	AD1
Number of Residues	2
Details	binding site for residue D12 A 811

Chain	Residue
A	PHE191
A	ASN330

site_id	AD2
Number of Residues	1
Details	binding site for residue D10 A 812

Chain	Residue
A	ASP485

site_id	AD3
Number of Residues	2
Details	binding site for residue D10 A 814

Chain	Residue
A	TYR204
B	GLN504

site_id	AD4
Number of Residues	3
Details	binding site for residue D12 A 815

Chain	Residue
A	CYS196
A	ARG197
A	D10816

site_id	AD5
Number of Residues	2
Details	binding site for residue D10 A 816

Chain	Residue
A	OCT805
A	D12815

site_id	AD6
Number of Residues	3
Details	binding site for residue D10 A 818

Chain	Residue
A	VAL298
A	THR301
A	PHE432

site_id	AD7
Number of Residues	3
Details	binding site for residue OCT A 819

Chain	Residue
A	GLY91
A	PHE294
A	VAL424

site_id	AD8
Number of Residues	1
Details	binding site for residue D10 A 820

Chain	Residue
A	LEU423

site_id	AD9
Number of Residues	1
Details	binding site for residue D10 A 822

Chain	Residue
A	TYR118

site_id	AE1
Number of Residues	2
Details	binding site for residue HP6 A 826

Chain	Residue
A	THR247
A	D10834

site_id	AE2
Number of Residues	1
Details	binding site for residue OCT A 827

Chain	Residue
A	D10828

site_id	AE3
Number of Residues	2
Details	binding site for residue D10 A 828

Chain	Residue
A	TYR501
A	OCT827

site_id	AE4
Number of Residues	1
Details	binding site for residue C14 A 829

Chain	Residue
A	THR470

site_id	AE5
Number of Residues	2
Details	binding site for residue C14 A 830

Chain	Residue
A	ILE467
B	OCT804

site_id	AE6
Number of Residues	1
Details	binding site for residue D10 A 831

Chain	Residue
A	TRP462

site_id	AE7
Number of Residues	1
Details	binding site for residue D10 A 832

Chain	Residue
A	PHE455

site_id	AE8
Number of Residues	1
Details	binding site for residue D10 A 834

Chain	Residue
A	HP6826

site_id	AE9
Number of Residues	1
Details	binding site for residue D10 A 836

Chain	Residue
A	PHE230

site_id	AF1
Number of Residues	1
Details	binding site for residue OCT A 837

Chain	Residue
A	HP6838

site_id	AF2
Number of Residues	3
Details	binding site for residue HP6 A 838

Chain	Residue
A	CYS260
A	GLY263
A	OCT837

site_id	AF3
Number of Residues	1
Details	binding site for residue D12 A 839

Chain	Residue
A	D12810

site_id	AF4
Number of Residues	1
Details	binding site for residue OCT A 843

Chain	Residue
A	TYR74

site_id	AF5
Number of Residues	1
Details	binding site for residue OCT A 845

Chain	Residue
A	VAL80

site_id	AF6
Number of Residues	1
Details	binding site for residue OCT A 846

Chain	Residue
A	LEU81

site_id	AF7
Number of Residues	3
Details	binding site for residue OCT A 847

Chain	Residue
A	GLY270
A	LEU273
A	OCT848

site_id	AF8
Number of Residues	1
Details	binding site for residue OCT A 848

Chain	Residue
A	OCT847

site_id	AF9
Number of Residues	2
Details	binding site for residue CL B 801

Chain	Residue
B	PHE137
B	SER396

site_id	AG1
Number of Residues	8
Details	binding site for residue CLR B 802

Chain	Residue
A	ILE493
A	CLR802
B	TYR486
B	ILE493
B	ILE494
B	LEU497
B	D10807
B	D10813

site_id	AG2
Number of Residues	2
Details	binding site for residue OCT B 804

Chain	Residue
A	C14830
B	TYR204

site_id	AG3
Number of Residues	2
Details	binding site for residue OCT B 805

Chain	Residue
B	OCT806
B	D10816

site_id	AG4
Number of Residues	1
Details	binding site for residue OCT B 806

Chain	Residue
B	OCT805

site_id	AG5
Number of Residues	1
Details	binding site for residue D10 B 807

Chain	Residue
B	CLR802

site_id	AG6
Number of Residues	1
Details	binding site for residue OCT B 808

Chain	Residue
B	TYR245

site_id	AG7
Number of Residues	1
Details	binding site for residue OCT B 809

Chain	Residue
B	PHE241

site_id	AG8
Number of Residues	1
Details	binding site for residue D12 B 810

Chain	Residue
B	D12838

site_id	AG9
Number of Residues	2
Details	binding site for residue D12 B 811

Chain	Residue
B	PHE191
B	ASN330

site_id	AH1
Number of Residues	1
Details	binding site for residue D10 B 812

Chain	Residue
B	ASP485

site_id	AH2
Number of Residues	1
Details	binding site for residue D10 B 813

Chain	Residue
B	CLR802

site_id	AH3
Number of Residues	2
Details	binding site for residue D10 B 814

Chain	Residue
A	GLN504
B	TYR204

site_id	AH4
Number of Residues	3
Details	binding site for residue D12 B 815

Chain	Residue
B	CYS196
B	ARG197
B	D10816

site_id	AH5
Number of Residues	2
Details	binding site for residue D10 B 816

Chain	Residue
B	OCT805
B	D12815

site_id	AH6
Number of Residues	4
Details	binding site for residue D10 B 818

Chain	Residue
B	VAL298
B	THR301
B	LEU431
B	PHE432

site_id	AH7
Number of Residues	3
Details	binding site for residue OCT B 819

Chain	Residue
B	GLY91
B	PHE294
B	VAL424

site_id	AH8
Number of Residues	1
Details	binding site for residue D10 B 820

Chain	Residue
B	LEU423

site_id	AH9
Number of Residues	1
Details	binding site for residue D10 B 822

Chain	Residue
B	TYR118

site_id	AI1
Number of Residues	2
Details	binding site for residue HP6 B 826

Chain	Residue
B	THR247
B	D10834

site_id	AI2
Number of Residues	1
Details	binding site for residue OCT B 827

Chain	Residue
B	D10828

site_id	AI3
Number of Residues	2
Details	binding site for residue D10 B 828

Chain	Residue
B	TYR501
B	OCT827

site_id	AI4
Number of Residues	1
Details	binding site for residue C14 B 829

Chain	Residue
B	THR470

site_id	AI5
Number of Residues	1
Details	binding site for residue C14 B 830

Chain	Residue
B	ILE467

site_id	AI6
Number of Residues	1
Details	binding site for residue D10 B 831

Chain	Residue
B	TRP462

site_id	AI7
Number of Residues	1
Details	binding site for residue D10 B 832

Chain	Residue
B	PHE455

site_id	AI8
Number of Residues	1
Details	binding site for residue D10 B 834

Chain	Residue
B	HP6826

site_id	AI9
Number of Residues	1
Details	binding site for residue D12 B 838

Chain	Residue
B	D12810

site_id	AJ1
Number of Residues	1
Details	binding site for residue OCT B 843

Chain	Residue
B	TYR74

site_id	AJ2
Number of Residues	1
Details	binding site for residue OCT B 845

Chain	Residue
B	VAL80

site_id	AJ3
Number of Residues	1
Details	binding site for residue OCT B 846

Chain	Residue
B	LEU81

site_id	AJ4
Number of Residues	2
Details	binding site for residue OCT B 847

Chain	Residue
B	GLY270
B	LEU273

Functional Information from PROSITE/UniProt

site_id	PS01130
Number of Residues	22
Details	SLC26A SLC26A transporters signature. PiFGLYSSfypvIMYcflGTSR

Chain	Residue	Details
A	PRO109-ARG130

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	134
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	66
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=5a","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	22
Details	Intramembrane: {"description":"Helical; Name=5b","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LGW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LH3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	20
Details	Motif: {"description":"Involved in motor function","evidences":[{"source":"UniProtKB","id":"Q9JKQ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34390643","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Controls the electromotile activity","evidences":[{"source":"UniProtKB","id":"A0FKN5","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q9EPH0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Contributes to anion binding","evidences":[{"source":"UniProtKB","id":"Q9EPH0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)