7LEX

Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0002250	biological_process	adaptive immune response
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0006527	biological_process	arginine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0019547	biological_process	arginine catabolic process to ornithine
A	0030145	molecular_function	manganese ion binding
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0002250	biological_process	adaptive immune response
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0006527	biological_process	arginine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0019547	biological_process	arginine catabolic process to ornithine
B	0030145	molecular_function	manganese ion binding
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0002250	biological_process	adaptive immune response
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0006527	biological_process	arginine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0019547	biological_process	arginine catabolic process to ornithine
C	0030145	molecular_function	manganese ion binding
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
J	0000050	biological_process	urea cycle
J	0002250	biological_process	adaptive immune response
J	0004053	molecular_function	arginase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006525	biological_process	arginine metabolic process
J	0006527	biological_process	arginine catabolic process
J	0016787	molecular_function	hydrolase activity
J	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
J	0019547	biological_process	arginine catabolic process to ornithine
J	0030145	molecular_function	manganese ion binding
J	0035578	cellular_component	azurophil granule lumen
J	0035580	cellular_component	specific granule lumen
J	0042130	biological_process	negative regulation of T cell proliferation
J	0042832	biological_process	defense response to protozoan
J	0045087	biological_process	innate immune response
J	0046007	biological_process	negative regulation of activated T cell proliferation
J	0046872	molecular_function	metal ion binding
J	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
J	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
J	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
M	0000050	biological_process	urea cycle
M	0002250	biological_process	adaptive immune response
M	0004053	molecular_function	arginase activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006525	biological_process	arginine metabolic process
M	0006527	biological_process	arginine catabolic process
M	0016787	molecular_function	hydrolase activity
M	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
M	0019547	biological_process	arginine catabolic process to ornithine
M	0030145	molecular_function	manganese ion binding
M	0035578	cellular_component	azurophil granule lumen
M	0035580	cellular_component	specific granule lumen
M	0042130	biological_process	negative regulation of T cell proliferation
M	0042832	biological_process	defense response to protozoan
M	0045087	biological_process	innate immune response
M	0046007	biological_process	negative regulation of activated T cell proliferation
M	0046872	molecular_function	metal ion binding
M	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
M	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
M	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
N	0000050	biological_process	urea cycle
N	0002250	biological_process	adaptive immune response
N	0004053	molecular_function	arginase activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006525	biological_process	arginine metabolic process
N	0006527	biological_process	arginine catabolic process
N	0016787	molecular_function	hydrolase activity
N	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
N	0019547	biological_process	arginine catabolic process to ornithine
N	0030145	molecular_function	manganese ion binding
N	0035578	cellular_component	azurophil granule lumen
N	0035580	cellular_component	specific granule lumen
N	0042130	biological_process	negative regulation of T cell proliferation
N	0042832	biological_process	defense response to protozoan
N	0045087	biological_process	innate immune response
N	0046007	biological_process	negative regulation of activated T cell proliferation
N	0046872	molecular_function	metal ion binding
N	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
N	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
N	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPsftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCSVVH

Chain	Residue	Details
D	TYR431-HIS437
E	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269|PubMed:16141327, ECO:0000269|PubMed:17469833, ECO:0000269|PubMed:17562323, ECO:0000269|PubMed:18802628, ECO:0000269|PubMed:21728378, ECO:0007744|PDB:1WVA, ECO:0007744|PDB:1WVB, ECO:0007744|PDB:2AEB, ECO:0007744|PDB:2PHA, ECO:0007744|PDB:2PHO, ECO:0007744|PDB:2PLL, ECO:0007744|PDB:2ZAV, ECO:0007744|PDB:3DJ8, ECO:0007744|PDB:3E6K, ECO:0007744|PDB:3E6V, ECO:0007744|PDB:3F80, ECO:0007744|PDB:3GMZ, ECO:0007744|PDB:3GN0, ECO:0007744|PDB:3KV2, ECO:0007744|PDB:3LP4, ECO:0007744|PDB:3LP7, ECO:0007744|PDB:3MFV, ECO:0007744|PDB:3MFW, ECO:0007744|PDB:3MJL, ECO:0007744|PDB:3SJT, ECO:0007744|PDB:3SKK, ECO:0007744|PDB:4FCI, ECO:0007744|PDB:4GSZ, ECO:0007744|PDB:4GWC, ECO:0007744|PDB:4GWD, ECO:0007744|PDB:4HWW, ECO:0007744|PDB:4HXQ, ECO:0007744|PDB:4IE1

Chain	Residue	Details
A	HIS101
B	ASP128
B	ASP232
B	ASP234
C	HIS101
C	ASP124
C	HIS126
C	ASP128
C	ASP232
C	ASP234
J	HIS101
A	ASP124
J	ASP124
J	HIS126
J	ASP128
J	ASP232
J	ASP234
M	HIS101
M	ASP124
M	HIS126
M	ASP128
M	ASP232
A	HIS126
M	ASP234
N	HIS101
N	ASP124
N	HIS126
N	ASP128
N	ASP232
N	ASP234
A	ASP128
A	ASP232
A	ASP234
B	HIS101
B	ASP124
B	HIS126

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:3GMZ, ECO:0007744|PDB:3GN0, ECO:0007744|PDB:3KV2, ECO:0007744|PDB:3LP7, ECO:0007744|PDB:3THJ

Chain	Residue	Details
A	SER137
M	ASP183
N	SER137
N	ASP183
A	ASP183
B	SER137
B	ASP183
C	SER137
C	ASP183
J	SER137
J	ASP183
M	SER137

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P53608

Chain	Residue	Details
A	THR246
B	THR246
C	THR246
J	THR246
M	THR246
N	THR246

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P78540

Chain	Residue	Details
A	GLU277
B	GLU277
C	GLU277
J	GLU277
M	GLU277
N	GLU277

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q61176

Chain	Residue	Details
A	LYS17
M	LYS75
N	LYS17
N	LYS75
A	LYS75
B	LYS17
B	LYS75
C	LYS17
C	LYS75
J	LYS17
J	LYS75
M	LYS17

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER62
J	SER62
J	SER163
J	SER217
M	SER62
M	SER163
M	SER217
N	SER62
N	SER163
N	SER217
A	SER163
A	SER217
B	SER62
B	SER163
B	SER217
C	SER62
C	SER163
C	SER217

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q61176

Chain	Residue	Details
A	SER72
B	SER72
C	SER72
J	SER72
M	SER72
N	SER72

---