7LDK

Structure of human respiratory syncytial virus nonstructural protein 2 (NS2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0033650	cellular_component	host cell mitochondrion
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
A	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A	0039557	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
A	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
A	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
A	0039723	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
A	0052031	biological_process	symbiont-mediated perturbation of host defense response
A	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0033650	cellular_component	host cell mitochondrion
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
B	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B	0039557	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
B	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
B	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
B	0039723	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0033650	cellular_component	host cell mitochondrion
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
C	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
C	0039557	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
C	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
C	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
C	0039723	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue TAR B 401

Chain	Residue
B	GLN56
C	LYS79

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL B 402

Chain	Residue
B	ILE116

---

site_id	AC3
Number of Residues	5
Details	binding site for residue TAR A 301

Chain	Residue
A	LYS112
B	ASP33
B	THR36
B	ARG38
B	LYS72

---

site_id	AC4
Number of Residues	3
Details	binding site for residue TAR A 302

Chain	Residue
A	GLN56
C	LYS77
A	ARG55

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL A 303

Chain	Residue
A	ARG50

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL A 304

Chain	Residue
A	ARG38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Motif: {"description":"DLNP; interaction with MAP1B","evidences":[{"source":"UniProtKB","id":"P04543","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---