Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7LCF

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, with pyruvate bound in the active site and L-lysine bound at the allosteric site in C121 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
B	0005737	cellular_component	cytoplasm
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009085	biological_process	lysine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0044281	biological_process	small molecule metabolic process
C	0005737	cellular_component	cytoplasm
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0005737	cellular_component	cytoplasm
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0044281	biological_process	small molecule metabolic process
E	0005737	cellular_component	cytoplasm
E	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
E	0009085	biological_process	lysine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0016829	molecular_function	lyase activity
E	0019877	biological_process	diaminopimelate biosynthetic process
E	0044281	biological_process	small molecule metabolic process
F	0005737	cellular_component	cytoplasm
F	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
F	0009085	biological_process	lysine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0016829	molecular_function	lyase activity
F	0019877	biological_process	diaminopimelate biosynthetic process
F	0044281	biological_process	small molecule metabolic process
G	0005737	cellular_component	cytoplasm
G	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
G	0009085	biological_process	lysine biosynthetic process
G	0009089	biological_process	lysine biosynthetic process via diaminopimelate
G	0016829	molecular_function	lyase activity
G	0019877	biological_process	diaminopimelate biosynthetic process
G	0044281	biological_process	small molecule metabolic process
H	0005737	cellular_component	cytoplasm
H	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
H	0009085	biological_process	lysine biosynthetic process
H	0009089	biological_process	lysine biosynthetic process via diaminopimelate
H	0016829	molecular_function	lyase activity
H	0019877	biological_process	diaminopimelate biosynthetic process
H	0044281	biological_process	small molecule metabolic process
I	0005737	cellular_component	cytoplasm
I	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
I	0009085	biological_process	lysine biosynthetic process
I	0009089	biological_process	lysine biosynthetic process via diaminopimelate
I	0016829	molecular_function	lyase activity
I	0019877	biological_process	diaminopimelate biosynthetic process
I	0044281	biological_process	small molecule metabolic process
J	0005737	cellular_component	cytoplasm
J	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
J	0009085	biological_process	lysine biosynthetic process
J	0009089	biological_process	lysine biosynthetic process via diaminopimelate
J	0016829	molecular_function	lyase activity
J	0019877	biological_process	diaminopimelate biosynthetic process
J	0044281	biological_process	small molecule metabolic process
K	0005737	cellular_component	cytoplasm
K	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
K	0009085	biological_process	lysine biosynthetic process
K	0009089	biological_process	lysine biosynthetic process via diaminopimelate
K	0016829	molecular_function	lyase activity
K	0019877	biological_process	diaminopimelate biosynthetic process
K	0044281	biological_process	small molecule metabolic process
L	0005737	cellular_component	cytoplasm
L	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
L	0009085	biological_process	lysine biosynthetic process
L	0009089	biological_process	lysine biosynthetic process via diaminopimelate
L	0016829	molecular_function	lyase activity
L	0019877	biological_process	diaminopimelate biosynthetic process
L	0044281	biological_process	small molecule metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. AVVpvGTTGESatltheE

Chain	Residue	Details
A	ALA41-GLU58

site_id	PS00666
Number of Residues	32
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNVPgrTgceIstdtiiklfrdcenIyGVKEA

Chain	Residue	Details
A	TYR137-ALA168

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	TYR137
J	TYR137
K	TYR137
L	TYR137
B	TYR137
C	TYR137
D	TYR137
E	TYR137
F	TYR137
G	TYR137
H	TYR137
I	TYR137

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	KPI166
J	KPI166
K	KPI166
L	KPI166
B	KPI166
C	KPI166
D	KPI166
E	KPI166
F	KPI166
G	KPI166
H	KPI166
I	KPI166

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	THR48
E	ILE207
F	THR48
F	ILE207
G	THR48
G	ILE207
H	THR48
H	ILE207
I	THR48
I	ILE207
J	THR48
A	ILE207
J	ILE207
K	THR48
K	ILE207
L	THR48
L	ILE207
B	THR48
B	ILE207
C	THR48
C	ILE207
D	THR48
D	ILE207
E	THR48

site_id	SWS_FT_FI4
Number of Residues	24
Details	SITE: Part of a proton relay during catalysis => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	THR47
E	TYR111
F	THR47
F	TYR111
G	THR47
G	TYR111
H	THR47
H	TYR111
I	THR47
I	TYR111
J	THR47
A	TYR111
J	TYR111
K	THR47
K	TYR111
L	THR47
L	TYR111
B	THR47
B	TYR111
C	THR47
C	TYR111
D	THR47
D	TYR111
E	THR47

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)