7LBA

E. coli Agmatinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0008295	biological_process	spermidine biosynthetic process
A	0008783	molecular_function	agmatinase activity
A	0009446	biological_process	putrescine biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0033388	biological_process	putrescine biosynthetic process from arginine
A	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0005829	cellular_component	cytosol
B	0008295	biological_process	spermidine biosynthetic process
B	0008783	molecular_function	agmatinase activity
B	0009446	biological_process	putrescine biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0033388	biological_process	putrescine biosynthetic process from arginine
B	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0005829	cellular_component	cytosol
C	0008295	biological_process	spermidine biosynthetic process
C	0008783	molecular_function	agmatinase activity
C	0009446	biological_process	putrescine biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0033388	biological_process	putrescine biosynthetic process from arginine
C	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0005829	cellular_component	cytosol
D	0008295	biological_process	spermidine biosynthetic process
D	0008783	molecular_function	agmatinase activity
D	0009446	biological_process	putrescine biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0030145	molecular_function	manganese ion binding
D	0033388	biological_process	putrescine biosynthetic process from arginine
D	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0005829	cellular_component	cytosol
E	0008295	biological_process	spermidine biosynthetic process
E	0008783	molecular_function	agmatinase activity
E	0009446	biological_process	putrescine biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0030145	molecular_function	manganese ion binding
E	0033388	biological_process	putrescine biosynthetic process from arginine
E	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0005829	cellular_component	cytosol
F	0008295	biological_process	spermidine biosynthetic process
F	0008783	molecular_function	agmatinase activity
F	0009446	biological_process	putrescine biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0030145	molecular_function	manganese ion binding
F	0033388	biological_process	putrescine biosynthetic process from arginine
F	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0005829	cellular_component	cytosol
G	0008295	biological_process	spermidine biosynthetic process
G	0008783	molecular_function	agmatinase activity
G	0009446	biological_process	putrescine biosynthetic process
G	0016787	molecular_function	hydrolase activity
G	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
G	0030145	molecular_function	manganese ion binding
G	0033388	biological_process	putrescine biosynthetic process from arginine
G	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0005829	cellular_component	cytosol
H	0008295	biological_process	spermidine biosynthetic process
H	0008783	molecular_function	agmatinase activity
H	0009446	biological_process	putrescine biosynthetic process
H	0016787	molecular_function	hydrolase activity
H	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
H	0030145	molecular_function	manganese ion binding
H	0033388	biological_process	putrescine biosynthetic process from arginine
H	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0005829	cellular_component	cytosol
I	0008295	biological_process	spermidine biosynthetic process
I	0008783	molecular_function	agmatinase activity
I	0009446	biological_process	putrescine biosynthetic process
I	0016787	molecular_function	hydrolase activity
I	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
I	0030145	molecular_function	manganese ion binding
I	0033388	biological_process	putrescine biosynthetic process from arginine
I	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0005829	cellular_component	cytosol
J	0008295	biological_process	spermidine biosynthetic process
J	0008783	molecular_function	agmatinase activity
J	0009446	biological_process	putrescine biosynthetic process
J	0016787	molecular_function	hydrolase activity
J	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
J	0030145	molecular_function	manganese ion binding
J	0033388	biological_process	putrescine biosynthetic process from arginine
J	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
K	0005829	cellular_component	cytosol
K	0008295	biological_process	spermidine biosynthetic process
K	0008783	molecular_function	agmatinase activity
K	0009446	biological_process	putrescine biosynthetic process
K	0016787	molecular_function	hydrolase activity
K	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
K	0030145	molecular_function	manganese ion binding
K	0033388	biological_process	putrescine biosynthetic process from arginine
K	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
L	0005829	cellular_component	cytosol
L	0008295	biological_process	spermidine biosynthetic process
L	0008783	molecular_function	agmatinase activity
L	0009446	biological_process	putrescine biosynthetic process
L	0016787	molecular_function	hydrolase activity
L	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
L	0030145	molecular_function	manganese ion binding
L	0033388	biological_process	putrescine biosynthetic process from arginine
L	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
M	0005829	cellular_component	cytosol
M	0008295	biological_process	spermidine biosynthetic process
M	0008783	molecular_function	agmatinase activity
M	0009446	biological_process	putrescine biosynthetic process
M	0016787	molecular_function	hydrolase activity
M	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
M	0030145	molecular_function	manganese ion binding
M	0033388	biological_process	putrescine biosynthetic process from arginine
M	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
M	0042802	molecular_function	identical protein binding
M	0046872	molecular_function	metal ion binding
N	0005829	cellular_component	cytosol
N	0008295	biological_process	spermidine biosynthetic process
N	0008783	molecular_function	agmatinase activity
N	0009446	biological_process	putrescine biosynthetic process
N	0016787	molecular_function	hydrolase activity
N	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
N	0030145	molecular_function	manganese ion binding
N	0033388	biological_process	putrescine biosynthetic process from arginine
N	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
N	0042802	molecular_function	identical protein binding
N	0046872	molecular_function	metal ion binding
O	0005829	cellular_component	cytosol
O	0008295	biological_process	spermidine biosynthetic process
O	0008783	molecular_function	agmatinase activity
O	0009446	biological_process	putrescine biosynthetic process
O	0016787	molecular_function	hydrolase activity
O	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
O	0030145	molecular_function	manganese ion binding
O	0033388	biological_process	putrescine biosynthetic process from arginine
O	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
O	0042802	molecular_function	identical protein binding
O	0046872	molecular_function	metal ion binding
P	0005829	cellular_component	cytosol
P	0008295	biological_process	spermidine biosynthetic process
P	0008783	molecular_function	agmatinase activity
P	0009446	biological_process	putrescine biosynthetic process
P	0016787	molecular_function	hydrolase activity
P	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
P	0030145	molecular_function	manganese ion binding
P	0033388	biological_process	putrescine biosynthetic process from arginine
P	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
P	0042802	molecular_function	identical protein binding
P	0046872	molecular_function	metal ion binding
Q	0005829	cellular_component	cytosol
Q	0008295	biological_process	spermidine biosynthetic process
Q	0008783	molecular_function	agmatinase activity
Q	0009446	biological_process	putrescine biosynthetic process
Q	0016787	molecular_function	hydrolase activity
Q	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Q	0030145	molecular_function	manganese ion binding
Q	0033388	biological_process	putrescine biosynthetic process from arginine
Q	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
Q	0042802	molecular_function	identical protein binding
Q	0046872	molecular_function	metal ion binding
R	0005829	cellular_component	cytosol
R	0008295	biological_process	spermidine biosynthetic process
R	0008783	molecular_function	agmatinase activity
R	0009446	biological_process	putrescine biosynthetic process
R	0016787	molecular_function	hydrolase activity
R	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
R	0030145	molecular_function	manganese ion binding
R	0033388	biological_process	putrescine biosynthetic process from arginine
R	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
R	0042802	molecular_function	identical protein binding
R	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. TFDIDcldPafaPGtgtpvigG

Chain	Residue	Details
A	THR228-GLY249

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	108
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS126
B	ASP153
Q	ASP153
Q	ASP230
Q	ASP232
R	HIS126
R	ASP149
R	HIS151
R	ASP153
R	ASP230
R	ASP232
B	ASP230
B	ASP232
C	HIS126
C	ASP149
C	HIS151
C	ASP153
C	ASP230
C	ASP232
D	HIS126
A	ASP149
D	ASP149
D	HIS151
D	ASP153
D	ASP230
D	ASP232
E	HIS126
E	ASP149
E	HIS151
E	ASP153
E	ASP230
A	HIS151
E	ASP232
F	HIS126
F	ASP149
F	HIS151
F	ASP153
F	ASP230
F	ASP232
G	HIS126
G	ASP149
G	HIS151
A	ASP153
G	ASP153
G	ASP230
G	ASP232
H	HIS126
H	ASP149
H	HIS151
H	ASP153
H	ASP230
H	ASP232
I	HIS126
A	ASP230
I	ASP149
I	HIS151
I	ASP153
I	ASP230
I	ASP232
J	HIS126
J	ASP149
J	HIS151
J	ASP153
J	ASP230
A	ASP232
J	ASP232
K	HIS126
K	ASP149
K	HIS151
K	ASP153
K	ASP230
K	ASP232
L	HIS126
L	ASP149
L	HIS151
B	HIS126
L	ASP153
L	ASP230
L	ASP232
M	HIS126
M	ASP149
M	HIS151
M	ASP153
M	ASP230
M	ASP232
N	HIS126
B	ASP149
N	ASP149
N	HIS151
N	ASP153
N	ASP230
N	ASP232
O	HIS126
O	ASP149
O	HIS151
O	ASP153
O	ASP230
B	HIS151
O	ASP232
P	HIS126
P	ASP149
P	HIS151
P	ASP153
P	ASP230
P	ASP232
Q	HIS126
Q	ASP149
Q	HIS151

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site_id	SWS_FT_FI2
Number of Residues	18
Details	SITE: Important for catalytic activity

Chain	Residue	Details
A	HIS163
J	HIS163
K	HIS163
L	HIS163
M	HIS163
N	HIS163
O	HIS163
P	HIS163
Q	HIS163
R	HIS163
B	HIS163
C	HIS163
D	HIS163
E	HIS163
F	HIS163
G	HIS163
H	HIS163
I	HIS163

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