Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7LB6

PDX1.2/PDX1.3 co-expression complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
A	0046982	molecular_function	protein heterodimerization activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0046982	molecular_function	protein heterodimerization activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0046982	molecular_function	protein heterodimerization activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0046982	molecular_function	protein heterodimerization activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0042819	biological_process	vitamin B6 biosynthetic process
I	0042823	biological_process	pyridoxal phosphate biosynthetic process
I	0046982	molecular_function	protein heterodimerization activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0042819	biological_process	vitamin B6 biosynthetic process
J	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	0046982	molecular_function	protein heterodimerization activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0042819	biological_process	vitamin B6 biosynthetic process
K	0042823	biological_process	pyridoxal phosphate biosynthetic process
K	0046982	molecular_function	protein heterodimerization activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0042819	biological_process	vitamin B6 biosynthetic process
L	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	0046982	molecular_function	protein heterodimerization activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006520	biological_process	amino acid metabolic process
M	0006979	biological_process	response to oxidative stress
M	0006982	biological_process	response to lipid hydroperoxide
M	0009651	biological_process	response to salt stress
M	0010224	biological_process	response to UV-B
M	0010335	biological_process	response to non-ionic osmotic stress
M	0012505	cellular_component	endomembrane system
M	0015994	biological_process	chlorophyll metabolic process
M	0016829	molecular_function	lyase activity
M	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
M	0042538	biological_process	hyperosmotic salinity response
M	0042803	molecular_function	protein homodimerization activity
M	0042819	biological_process	vitamin B6 biosynthetic process
M	0042823	biological_process	pyridoxal phosphate biosynthetic process
M	0046982	molecular_function	protein heterodimerization activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006520	biological_process	amino acid metabolic process
N	0006979	biological_process	response to oxidative stress
N	0006982	biological_process	response to lipid hydroperoxide
N	0009651	biological_process	response to salt stress
N	0010224	biological_process	response to UV-B
N	0010335	biological_process	response to non-ionic osmotic stress
N	0012505	cellular_component	endomembrane system
N	0015994	biological_process	chlorophyll metabolic process
N	0016829	molecular_function	lyase activity
N	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
N	0042538	biological_process	hyperosmotic salinity response
N	0042803	molecular_function	protein homodimerization activity
N	0042819	biological_process	vitamin B6 biosynthetic process
N	0042823	biological_process	pyridoxal phosphate biosynthetic process
N	0046982	molecular_function	protein heterodimerization activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006520	biological_process	amino acid metabolic process
O	0006979	biological_process	response to oxidative stress
O	0006982	biological_process	response to lipid hydroperoxide
O	0009651	biological_process	response to salt stress
O	0010224	biological_process	response to UV-B
O	0010335	biological_process	response to non-ionic osmotic stress
O	0012505	cellular_component	endomembrane system
O	0015994	biological_process	chlorophyll metabolic process
O	0016829	molecular_function	lyase activity
O	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
O	0042538	biological_process	hyperosmotic salinity response
O	0042803	molecular_function	protein homodimerization activity
O	0042819	biological_process	vitamin B6 biosynthetic process
O	0042823	biological_process	pyridoxal phosphate biosynthetic process
O	0046982	molecular_function	protein heterodimerization activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006520	biological_process	amino acid metabolic process
P	0006979	biological_process	response to oxidative stress
P	0006982	biological_process	response to lipid hydroperoxide
P	0009651	biological_process	response to salt stress
P	0010224	biological_process	response to UV-B
P	0010335	biological_process	response to non-ionic osmotic stress
P	0012505	cellular_component	endomembrane system
P	0015994	biological_process	chlorophyll metabolic process
P	0016829	molecular_function	lyase activity
P	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
P	0042538	biological_process	hyperosmotic salinity response
P	0042803	molecular_function	protein homodimerization activity
P	0042819	biological_process	vitamin B6 biosynthetic process
P	0042823	biological_process	pyridoxal phosphate biosynthetic process
P	0046982	molecular_function	protein heterodimerization activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006520	biological_process	amino acid metabolic process
Q	0006979	biological_process	response to oxidative stress
Q	0006982	biological_process	response to lipid hydroperoxide
Q	0009651	biological_process	response to salt stress
Q	0010224	biological_process	response to UV-B
Q	0010335	biological_process	response to non-ionic osmotic stress
Q	0012505	cellular_component	endomembrane system
Q	0015994	biological_process	chlorophyll metabolic process
Q	0016829	molecular_function	lyase activity
Q	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Q	0042538	biological_process	hyperosmotic salinity response
Q	0042803	molecular_function	protein homodimerization activity
Q	0042819	biological_process	vitamin B6 biosynthetic process
Q	0042823	biological_process	pyridoxal phosphate biosynthetic process
Q	0046982	molecular_function	protein heterodimerization activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006520	biological_process	amino acid metabolic process
R	0006979	biological_process	response to oxidative stress
R	0006982	biological_process	response to lipid hydroperoxide
R	0009651	biological_process	response to salt stress
R	0010224	biological_process	response to UV-B
R	0010335	biological_process	response to non-ionic osmotic stress
R	0012505	cellular_component	endomembrane system
R	0015994	biological_process	chlorophyll metabolic process
R	0016829	molecular_function	lyase activity
R	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
R	0042538	biological_process	hyperosmotic salinity response
R	0042803	molecular_function	protein homodimerization activity
R	0042819	biological_process	vitamin B6 biosynthetic process
R	0042823	biological_process	pyridoxal phosphate biosynthetic process
R	0046982	molecular_function	protein heterodimerization activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005886	cellular_component	plasma membrane
S	0006520	biological_process	amino acid metabolic process
S	0006979	biological_process	response to oxidative stress
S	0006982	biological_process	response to lipid hydroperoxide
S	0009651	biological_process	response to salt stress
S	0010224	biological_process	response to UV-B
S	0010335	biological_process	response to non-ionic osmotic stress
S	0012505	cellular_component	endomembrane system
S	0015994	biological_process	chlorophyll metabolic process
S	0016829	molecular_function	lyase activity
S	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
S	0042538	biological_process	hyperosmotic salinity response
S	0042803	molecular_function	protein homodimerization activity
S	0042819	biological_process	vitamin B6 biosynthetic process
S	0042823	biological_process	pyridoxal phosphate biosynthetic process
S	0046982	molecular_function	protein heterodimerization activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005886	cellular_component	plasma membrane
T	0006520	biological_process	amino acid metabolic process
T	0006979	biological_process	response to oxidative stress
T	0006982	biological_process	response to lipid hydroperoxide
T	0009651	biological_process	response to salt stress
T	0010224	biological_process	response to UV-B
T	0010335	biological_process	response to non-ionic osmotic stress
T	0012505	cellular_component	endomembrane system
T	0015994	biological_process	chlorophyll metabolic process
T	0016829	molecular_function	lyase activity
T	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
T	0042538	biological_process	hyperosmotic salinity response
T	0042803	molecular_function	protein homodimerization activity
T	0042819	biological_process	vitamin B6 biosynthetic process
T	0042823	biological_process	pyridoxal phosphate biosynthetic process
T	0046982	molecular_function	protein heterodimerization activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0006520	biological_process	amino acid metabolic process
U	0006979	biological_process	response to oxidative stress
U	0006982	biological_process	response to lipid hydroperoxide
U	0009651	biological_process	response to salt stress
U	0010224	biological_process	response to UV-B
U	0010335	biological_process	response to non-ionic osmotic stress
U	0012505	cellular_component	endomembrane system
U	0015994	biological_process	chlorophyll metabolic process
U	0016829	molecular_function	lyase activity
U	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
U	0042538	biological_process	hyperosmotic salinity response
U	0042803	molecular_function	protein homodimerization activity
U	0042819	biological_process	vitamin B6 biosynthetic process
U	0042823	biological_process	pyridoxal phosphate biosynthetic process
U	0046982	molecular_function	protein heterodimerization activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005886	cellular_component	plasma membrane
V	0006520	biological_process	amino acid metabolic process
V	0006979	biological_process	response to oxidative stress
V	0006982	biological_process	response to lipid hydroperoxide
V	0009651	biological_process	response to salt stress
V	0010224	biological_process	response to UV-B
V	0010335	biological_process	response to non-ionic osmotic stress
V	0012505	cellular_component	endomembrane system
V	0015994	biological_process	chlorophyll metabolic process
V	0016829	molecular_function	lyase activity
V	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
V	0042538	biological_process	hyperosmotic salinity response
V	0042803	molecular_function	protein homodimerization activity
V	0042819	biological_process	vitamin B6 biosynthetic process
V	0042823	biological_process	pyridoxal phosphate biosynthetic process
V	0046982	molecular_function	protein heterodimerization activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006520	biological_process	amino acid metabolic process
W	0006979	biological_process	response to oxidative stress
W	0006982	biological_process	response to lipid hydroperoxide
W	0009651	biological_process	response to salt stress
W	0010224	biological_process	response to UV-B
W	0010335	biological_process	response to non-ionic osmotic stress
W	0012505	cellular_component	endomembrane system
W	0015994	biological_process	chlorophyll metabolic process
W	0016829	molecular_function	lyase activity
W	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
W	0042538	biological_process	hyperosmotic salinity response
W	0042803	molecular_function	protein homodimerization activity
W	0042819	biological_process	vitamin B6 biosynthetic process
W	0042823	biological_process	pyridoxal phosphate biosynthetic process
W	0046982	molecular_function	protein heterodimerization activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005886	cellular_component	plasma membrane
X	0006520	biological_process	amino acid metabolic process
X	0006979	biological_process	response to oxidative stress
X	0006982	biological_process	response to lipid hydroperoxide
X	0009651	biological_process	response to salt stress
X	0010224	biological_process	response to UV-B
X	0010335	biological_process	response to non-ionic osmotic stress
X	0012505	cellular_component	endomembrane system
X	0015994	biological_process	chlorophyll metabolic process
X	0016829	molecular_function	lyase activity
X	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
X	0042538	biological_process	hyperosmotic salinity response
X	0042803	molecular_function	protein homodimerization activity
X	0042819	biological_process	vitamin B6 biosynthetic process
X	0042823	biological_process	pyridoxal phosphate biosynthetic process
X	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. VPVVQFASGGITTPADAAL

Chain	Residue	Details
A	VAL197-LEU215
M	LEU200-LEU218

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Schiff-base intermediate with D-ribose 5-phosphate => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
M	LYS76
V	LYS2443
W	LYS2706
X	LYS2969
N	LYS339
O	LYS602
P	LYS865
Q	LYS1128
R	LYS1391
S	LYS1654
T	LYS1917
U	LYS2180

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
M	ASP19
O	GLY674
O	GLY735
O	GLY756
P	ASP808
P	GLY937
P	GLY998
P	GLY1019
Q	ASP1071
Q	GLY1200
Q	GLY1261
M	GLY148
Q	GLY1282
R	ASP1334
R	GLY1463
R	GLY1524
R	GLY1545
S	ASP1597
S	GLY1726
S	GLY1787
S	GLY1808
T	ASP1860
M	GLY209
T	GLY1989
T	GLY2050
T	GLY2071
U	ASP2123
U	GLY2252
U	GLY2313
U	GLY2334
V	ASP2386
V	GLY2515
V	GLY2576
M	GLY230
V	GLY2597
W	ASP2649
W	GLY2778
W	GLY2839
W	GLY2860
X	ASP2912
X	GLY3041
X	GLY3102
X	GLY3123
N	ASP282
N	GLY411
N	GLY472
N	GLY493
O	ASP545

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q03148

Chain	Residue	Details
M	ARG160
V	ARG2527
W	ARG2790
X	ARG3053
N	ARG423
O	ARG686
P	ARG949
Q	ARG1212
R	ARG1475
S	ARG1738
T	ARG2001
U	ARG2264

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)