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7L9M

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with bivalent inhibitor GXH-II-083

Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH355

site_idAC2
Number of Residues7
Detailsbinding site for residue EDO A 202
ChainResidue
AHOH301
AHOH305
BTRP81
BGLN84
AASP145
ALEU148
AXR4204

site_idAC3
Number of Residues7
Detailsbinding site for residue EDO A 203
ChainResidue
ASER42
AMET43
AASN44
AALA89
APRO95
ATYR98
BPRO56

site_idAC4
Number of Residues29
Detailsbinding site for residue XR4 A 204
ChainResidue
AGLN78
APHE79
ATRP81
APRO82
AVAL87
ALYS91
ALEU92
AASN140
AASP145
AILE146
AMET149
AEDO202
AHOH307
AHOH337
AHOH373
AHOH391
BPRO82
BPRO86
BVAL87
BASP88
BVAL90
BLYS91
BLEU92
BASN93
BLEU94
BASN140
BGLN159
BHOH392
BHOH434

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO B 201
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
BASN140
AASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS99
ALYS99

221051

PDB entries from 2024-06-12

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