Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7L6N

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009408	biological_process	response to heat
A	0016887	molecular_function	ATP hydrolysis activity
A	0034605	biological_process	cellular response to heat
A	0042026	biological_process	protein refolding
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009408	biological_process	response to heat
B	0016887	molecular_function	ATP hydrolysis activity
B	0034605	biological_process	cellular response to heat
B	0042026	biological_process	protein refolding
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009408	biological_process	response to heat
C	0016887	molecular_function	ATP hydrolysis activity
C	0034605	biological_process	cellular response to heat
C	0042026	biological_process	protein refolding
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009408	biological_process	response to heat
D	0016887	molecular_function	ATP hydrolysis activity
D	0034605	biological_process	cellular response to heat
D	0042026	biological_process	protein refolding
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0009408	biological_process	response to heat
E	0016887	molecular_function	ATP hydrolysis activity
E	0034605	biological_process	cellular response to heat
E	0042026	biological_process	protein refolding
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0009408	biological_process	response to heat
F	0016887	molecular_function	ATP hydrolysis activity
F	0034605	biological_process	cellular response to heat
F	0042026	biological_process	protein refolding
I	0000166	molecular_function	nucleotide binding
I	0001968	molecular_function	fibronectin binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006457	biological_process	protein folding
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0009408	biological_process	response to heat
I	0009986	cellular_component	cell surface
I	0010756	biological_process	positive regulation of plasminogen activation
I	0016887	molecular_function	ATP hydrolysis activity
I	0031072	molecular_function	heat shock protein binding
I	0035375	molecular_function	zymogen binding
I	0042026	biological_process	protein refolding
I	0042603	cellular_component	capsule
I	0044183	molecular_function	protein folding chaperone
I	0044406	biological_process	adhesion of symbiont to host
I	0046677	biological_process	response to antibiotic
I	0046688	biological_process	response to copper ion
I	0051082	molecular_function	unfolded protein binding
I	0071451	biological_process	cellular response to superoxide
I	0097691	cellular_component	bacterial extracellular vesicle
J	0000166	molecular_function	nucleotide binding
J	0001968	molecular_function	fibronectin binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006457	biological_process	protein folding
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0009408	biological_process	response to heat
J	0009986	cellular_component	cell surface
J	0010756	biological_process	positive regulation of plasminogen activation
J	0016887	molecular_function	ATP hydrolysis activity
J	0031072	molecular_function	heat shock protein binding
J	0035375	molecular_function	zymogen binding
J	0042026	biological_process	protein refolding
J	0042603	cellular_component	capsule
J	0044183	molecular_function	protein folding chaperone
J	0044406	biological_process	adhesion of symbiont to host
J	0046677	biological_process	response to antibiotic
J	0046688	biological_process	response to copper ion
J	0051082	molecular_function	unfolded protein binding
J	0071451	biological_process	cellular response to superoxide
J	0097691	cellular_component	bacterial extracellular vesicle
K	0000166	molecular_function	nucleotide binding
K	0001968	molecular_function	fibronectin binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006457	biological_process	protein folding
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0009408	biological_process	response to heat
K	0009986	cellular_component	cell surface
K	0010756	biological_process	positive regulation of plasminogen activation
K	0016887	molecular_function	ATP hydrolysis activity
K	0031072	molecular_function	heat shock protein binding
K	0035375	molecular_function	zymogen binding
K	0042026	biological_process	protein refolding
K	0042603	cellular_component	capsule
K	0044183	molecular_function	protein folding chaperone
K	0044406	biological_process	adhesion of symbiont to host
K	0046677	biological_process	response to antibiotic
K	0046688	biological_process	response to copper ion
K	0051082	molecular_function	unfolded protein binding
K	0071451	biological_process	cellular response to superoxide
K	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PROSITE/UniProt

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTnS

Chain	Residue	Details
I	ILE65-SER72

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. VFDLGGGTfdvSLL

Chain	Residue	Details
I	VAL226-LEU239

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DAGNMIKPmLarG

Chain	Residue	Details
A	ASP295-GLY307

site_id	PS00871
Number of Residues	19
Details	CLPAB_2 Chaperonins clpA/B signature 2. RIDmSEYgEKhTvARLiGA

Chain	Residue	Details
A	ARG633-ALA651

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. VvLvGGsTRMPaVtD

Chain	Residue	Details
I	VAL368-ASP382

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1188
Details	Region: {"description":"NBD2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	84
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)