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7L6N

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0009274cellular_componentpeptidoglycan-based cell wall
A0009408biological_processresponse to heat
A0016887molecular_functionATP hydrolysis activity
A0034605biological_processcellular response to heat
A0042026biological_processprotein refolding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0009274cellular_componentpeptidoglycan-based cell wall
B0009408biological_processresponse to heat
B0016887molecular_functionATP hydrolysis activity
B0034605biological_processcellular response to heat
B0042026biological_processprotein refolding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0009274cellular_componentpeptidoglycan-based cell wall
C0009408biological_processresponse to heat
C0016887molecular_functionATP hydrolysis activity
C0034605biological_processcellular response to heat
C0042026biological_processprotein refolding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0009274cellular_componentpeptidoglycan-based cell wall
D0009408biological_processresponse to heat
D0016887molecular_functionATP hydrolysis activity
D0034605biological_processcellular response to heat
D0042026biological_processprotein refolding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0009274cellular_componentpeptidoglycan-based cell wall
E0009408biological_processresponse to heat
E0016887molecular_functionATP hydrolysis activity
E0034605biological_processcellular response to heat
E0042026biological_processprotein refolding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0009274cellular_componentpeptidoglycan-based cell wall
F0009408biological_processresponse to heat
F0016887molecular_functionATP hydrolysis activity
F0034605biological_processcellular response to heat
F0042026biological_processprotein refolding
I0001968molecular_functionfibronectin binding
I0005524molecular_functionATP binding
I0005576cellular_componentextracellular region
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006457biological_processprotein folding
I0009274cellular_componentpeptidoglycan-based cell wall
I0009408biological_processresponse to heat
I0009986cellular_componentcell surface
I0010756biological_processpositive regulation of plasminogen activation
I0016887molecular_functionATP hydrolysis activity
I0031072molecular_functionheat shock protein binding
I0035375molecular_functionzymogen binding
I0042026biological_processprotein refolding
I0042603cellular_componentcapsule
I0044183molecular_functionprotein folding chaperone
I0044406biological_processadhesion of symbiont to host
I0046677biological_processresponse to antibiotic
I0046688biological_processresponse to copper ion
I0046777biological_processprotein autophosphorylation
I0051082molecular_functionunfolded protein binding
I0051085biological_processchaperone cofactor-dependent protein refolding
I0071451biological_processcellular response to superoxide
I0097691cellular_componentbacterial extracellular vesicle
I0140662molecular_functionATP-dependent protein folding chaperone
I2000679biological_processpositive regulation of transcription regulatory region DNA binding
J0001968molecular_functionfibronectin binding
J0005524molecular_functionATP binding
J0005576cellular_componentextracellular region
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006457biological_processprotein folding
J0009274cellular_componentpeptidoglycan-based cell wall
J0009408biological_processresponse to heat
J0009986cellular_componentcell surface
J0010756biological_processpositive regulation of plasminogen activation
J0016887molecular_functionATP hydrolysis activity
J0031072molecular_functionheat shock protein binding
J0035375molecular_functionzymogen binding
J0042026biological_processprotein refolding
J0042603cellular_componentcapsule
J0044183molecular_functionprotein folding chaperone
J0044406biological_processadhesion of symbiont to host
J0046677biological_processresponse to antibiotic
J0046688biological_processresponse to copper ion
J0046777biological_processprotein autophosphorylation
J0051082molecular_functionunfolded protein binding
J0051085biological_processchaperone cofactor-dependent protein refolding
J0071451biological_processcellular response to superoxide
J0097691cellular_componentbacterial extracellular vesicle
J0140662molecular_functionATP-dependent protein folding chaperone
J2000679biological_processpositive regulation of transcription regulatory region DNA binding
K0001968molecular_functionfibronectin binding
K0005524molecular_functionATP binding
K0005576cellular_componentextracellular region
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006457biological_processprotein folding
K0009274cellular_componentpeptidoglycan-based cell wall
K0009408biological_processresponse to heat
K0009986cellular_componentcell surface
K0010756biological_processpositive regulation of plasminogen activation
K0016887molecular_functionATP hydrolysis activity
K0031072molecular_functionheat shock protein binding
K0035375molecular_functionzymogen binding
K0042026biological_processprotein refolding
K0042603cellular_componentcapsule
K0044183molecular_functionprotein folding chaperone
K0044406biological_processadhesion of symbiont to host
K0046677biological_processresponse to antibiotic
K0046688biological_processresponse to copper ion
K0046777biological_processprotein autophosphorylation
K0051082molecular_functionunfolded protein binding
K0051085biological_processchaperone cofactor-dependent protein refolding
K0071451biological_processcellular response to superoxide
K0097691cellular_componentbacterial extracellular vesicle
K0140662molecular_functionATP-dependent protein folding chaperone
K2000679biological_processpositive regulation of transcription regulatory region DNA binding
Functional Information from PROSITE/UniProt
site_idPS00297
Number of Residues8
DetailsHSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTnS
ChainResidueDetails
IILE65-SER72

site_idPS00329
Number of Residues14
DetailsHSP70_2 Heat shock hsp70 proteins family signature 2. VFDLGGGTfdvSLL
ChainResidueDetails
IVAL226-LEU239

site_idPS00870
Number of Residues13
DetailsCLPAB_1 Chaperonins clpA/B signature 1. DAGNMIKPmLarG
ChainResidueDetails
AASP295-GLY307

site_idPS00871
Number of Residues19
DetailsCLPAB_2 Chaperonins clpA/B signature 2. RIDmSEYgEKhTvARLiGA
ChainResidueDetails
AARG633-ALA651

site_idPS01036
Number of Residues15
DetailsHSP70_3 Heat shock hsp70 proteins family signature 3. VvLvGGsTRMPaVtD
ChainResidueDetails
IVAL368-ASP382

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250
ChainResidueDetails
ITHR233
EGLY607
FGLY206
FGLY607
JTHR233
KTHR233
BGLY607
CGLY206
CGLY607
DGLY206
DGLY607
EGLY206

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PDB entries from 2024-07-17

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