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7L50

Crystal structure of human monoacylglycerol lipase in complex with compound 4f

Functional Information from GO Data
ChainGOidnamespacecontents
A0004622molecular_functionlysophospholipase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006639biological_processacylglycerol metabolic process
A0006954biological_processinflammatory response
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0019369biological_processarachidonic acid metabolic process
A0019433biological_processtriglyceride catabolic process
A0042803molecular_functionprotein homodimerization activity
A0046464biological_processacylglycerol catabolic process
A0047372molecular_functionacylglycerol lipase activity
A0050727biological_processregulation of inflammatory response
A0051930biological_processregulation of sensory perception of pain
A0052651biological_processmonoacylglycerol catabolic process
A0052689molecular_functioncarboxylic ester hydrolase activity
A2000124biological_processregulation of endocannabinoid signaling pathway
B0004622molecular_functionlysophospholipase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006639biological_processacylglycerol metabolic process
B0006954biological_processinflammatory response
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0019369biological_processarachidonic acid metabolic process
B0019433biological_processtriglyceride catabolic process
B0042803molecular_functionprotein homodimerization activity
B0046464biological_processacylglycerol catabolic process
B0047372molecular_functionacylglycerol lipase activity
B0050727biological_processregulation of inflammatory response
B0051930biological_processregulation of sensory perception of pain
B0052651biological_processmonoacylglycerol catabolic process
B0052689molecular_functioncarboxylic ester hydrolase activity
B2000124biological_processregulation of endocannabinoid signaling pathway
C0004622molecular_functionlysophospholipase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006633biological_processfatty acid biosynthetic process
C0006639biological_processacylglycerol metabolic process
C0006954biological_processinflammatory response
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0019369biological_processarachidonic acid metabolic process
C0019433biological_processtriglyceride catabolic process
C0042803molecular_functionprotein homodimerization activity
C0046464biological_processacylglycerol catabolic process
C0047372molecular_functionacylglycerol lipase activity
C0050727biological_processregulation of inflammatory response
C0051930biological_processregulation of sensory perception of pain
C0052651biological_processmonoacylglycerol catabolic process
C0052689molecular_functioncarboxylic ester hydrolase activity
C2000124biological_processregulation of endocannabinoid signaling pathway
D0004622molecular_functionlysophospholipase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006633biological_processfatty acid biosynthetic process
D0006639biological_processacylglycerol metabolic process
D0006954biological_processinflammatory response
D0009966biological_processregulation of signal transduction
D0016020cellular_componentmembrane
D0016042biological_processlipid catabolic process
D0019369biological_processarachidonic acid metabolic process
D0019433biological_processtriglyceride catabolic process
D0042803molecular_functionprotein homodimerization activity
D0046464biological_processacylglycerol catabolic process
D0047372molecular_functionacylglycerol lipase activity
D0050727biological_processregulation of inflammatory response
D0051930biological_processregulation of sensory perception of pain
D0052651biological_processmonoacylglycerol catabolic process
D0052689molecular_functioncarboxylic ester hydrolase activity
D2000124biological_processregulation of endocannabinoid signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VFLLGHSMGG
ChainResidueDetails
AVAL116-GLY125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:19957260
ChainResidueDetails
ASER122
BSER122
CSER122
DSER122

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:19957260
ChainResidueDetails
AASP239
AHIS269
BASP239
BHIS269
CASP239
CHIS269
DASP239
DHIS269

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ATHR10
BTHR10
CTHR10
DTHR10

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ATYR58
BTYR58
CTYR58
DTYR58

222415

PDB entries from 2024-07-10

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