7L50

Crystal structure of human monoacylglycerol lipase in complex with compound 4f

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006954	biological_process	inflammatory response
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019369	biological_process	arachidonate metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046464	biological_process	acylglycerol catabolic process
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0050727	biological_process	regulation of inflammatory response
A	0051930	biological_process	regulation of sensory perception of pain
A	0052651	biological_process	monoacylglycerol catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	2000124	biological_process	regulation of endocannabinoid signaling pathway
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006954	biological_process	inflammatory response
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019369	biological_process	arachidonate metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0046464	biological_process	acylglycerol catabolic process
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0050727	biological_process	regulation of inflammatory response
B	0051930	biological_process	regulation of sensory perception of pain
B	0052651	biological_process	monoacylglycerol catabolic process
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	2000124	biological_process	regulation of endocannabinoid signaling pathway
C	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006954	biological_process	inflammatory response
C	0009966	biological_process	regulation of signal transduction
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019369	biological_process	arachidonate metabolic process
C	0019433	biological_process	triglyceride catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0046464	biological_process	acylglycerol catabolic process
C	0047372	molecular_function	monoacylglycerol lipase activity
C	0050727	biological_process	regulation of inflammatory response
C	0051930	biological_process	regulation of sensory perception of pain
C	0052651	biological_process	monoacylglycerol catabolic process
C	0052689	molecular_function	carboxylic ester hydrolase activity
C	2000124	biological_process	regulation of endocannabinoid signaling pathway
D	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
D	0005515	molecular_function	protein binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006954	biological_process	inflammatory response
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0019369	biological_process	arachidonate metabolic process
D	0019433	biological_process	triglyceride catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0046464	biological_process	acylglycerol catabolic process
D	0047372	molecular_function	monoacylglycerol lipase activity
D	0050727	biological_process	regulation of inflammatory response
D	0051930	biological_process	regulation of sensory perception of pain
D	0052651	biological_process	monoacylglycerol catabolic process
D	0052689	molecular_function	carboxylic ester hydrolase activity
D	2000124	biological_process	regulation of endocannabinoid signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLLGHSMGG

Chain	Residue	Details
A	VAL116-GLY125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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