7L4T
Crystal structure of human monoacylglycerol lipase in complex with compound 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004622 | molecular_function | phosphatidylcholine lysophospholipase A1 activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0019369 | biological_process | arachidonate metabolic process |
| A | 0019433 | biological_process | triglyceride catabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046464 | biological_process | acylglycerol catabolic process |
| A | 0047372 | molecular_function | monoacylglycerol lipase activity |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051930 | biological_process | regulation of sensory perception of pain |
| A | 0052651 | biological_process | monoacylglycerol catabolic process |
| A | 2000124 | biological_process | regulation of endocannabinoid signaling pathway |
| B | 0004622 | molecular_function | phosphatidylcholine lysophospholipase A1 activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0009966 | biological_process | regulation of signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0019369 | biological_process | arachidonate metabolic process |
| B | 0019433 | biological_process | triglyceride catabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046464 | biological_process | acylglycerol catabolic process |
| B | 0047372 | molecular_function | monoacylglycerol lipase activity |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 0051930 | biological_process | regulation of sensory perception of pain |
| B | 0052651 | biological_process | monoacylglycerol catabolic process |
| B | 2000124 | biological_process | regulation of endocannabinoid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue XPD A 2501 |
| Chain | Residue |
| A | ALA51 |
| A | LEU214 |
| A | HIS269 |
| A | VAL270 |
| A | GLU53 |
| A | ARG57 |
| A | HIS121 |
| A | SER122 |
| A | MET123 |
| A | LEU184 |
| A | TYR194 |
| A | LEU205 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 2502 |
| Chain | Residue |
| A | TYR111 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MPD B 401 |
| Chain | Residue |
| B | LEU241 |
| B | MPD402 |
| B | MPD403 |
| B | HOH528 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MPD B 402 |
| Chain | Residue |
| B | ALA151 |
| B | ASN152 |
| B | SER155 |
| B | LEU205 |
| B | GLY210 |
| B | MPD401 |
| B | HOH608 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue MPD B 403 |
| Chain | Residue |
| B | GLY50 |
| B | ALA51 |
| B | GLU53 |
| B | HIS121 |
| B | TYR194 |
| B | VAL270 |
| B | MPD401 |
| B | HOH541 |
| B | HOH565 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MPD B 404 |
| Chain | Residue |
| A | GLN102 |
| B | HOH503 |
| B | HOH530 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| B | TYR111 |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VFLLGHSMGG |
| Chain | Residue | Details |
| A | VAL116-GLY125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
