7KYZ
Solution structures of full-length K-RAS bound to GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001889 | biological_process | liver development |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0007565 | biological_process | female pregnancy |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0008542 | biological_process | visual learning |
| A | 0009629 | biological_process | response to gravity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010467 | biological_process | gene expression |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014009 | biological_process | glial cell proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019002 | molecular_function | GMP binding |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0021897 | biological_process | forebrain astrocyte development |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030275 | molecular_function | LRR domain binding |
| A | 0030857 | biological_process | negative regulation of epithelial cell differentiation |
| A | 0032228 | biological_process | regulation of synaptic transmission, GABAergic |
| A | 0035022 | biological_process | positive regulation of Rac protein signal transduction |
| A | 0035900 | biological_process | response to isolation stress |
| A | 0035914 | biological_process | skeletal muscle cell differentiation |
| A | 0043495 | molecular_function | membrane-membrane adaptor activity |
| A | 0043524 | biological_process | negative regulation of neuron apoptotic process |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0048169 | biological_process | regulation of long-term neuronal synaptic plasticity |
| A | 0048873 | biological_process | homeostasis of number of cells within a tissue |
| A | 0051146 | biological_process | striated muscle cell differentiation |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0051385 | biological_process | response to mineralocorticoid |
| A | 0051402 | biological_process | neuron apoptotic process |
| A | 0051450 | biological_process | myoblast proliferation |
| A | 0060038 | biological_process | cardiac muscle cell proliferation |
| A | 0060252 | biological_process | positive regulation of glial cell proliferation |
| A | 0060441 | biological_process | epithelial tube branching involved in lung morphogenesis |
| A | 0060509 | biological_process | type I pneumocyte differentiation |
| A | 2000774 | biological_process | positive regulation of cellular senescence |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000281291","evidences":[{"source":"PubMed","id":"27791178","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"27791178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"N6-palmitoyl lysine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"N6-palmitoyl lysine","evidences":[{"source":"PubMed","id":"29239724","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"27791178","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24415755","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TB5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
