7KYH
Botulism Neurooxin Light Chain A app form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLAHELIHAG |
| Chain | Residue | Details |
| A | THR220-GLY229 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:10694409 |
| Chain | Residue | Details |
| A | GLU224 | |
| B | GLU224 | |
| C | GLU224 | |
| D | GLU224 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
| Chain | Residue | Details |
| A | HIS223 | |
| B | HIS223 | |
| C | HIS223 | |
| D | HIS223 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0000305|PubMed:7578132, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
| Chain | Residue | Details |
| A | HIS227 | |
| B | HIS227 | |
| C | HIS227 | |
| D | HIS227 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0000305|PubMed:11700044, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
| Chain | Residue | Details |
| A | GLU262 | |
| B | GLU262 | |
| C | GLU262 | |
| D | GLU262 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:11827515 |
| Chain | Residue | Details |
| A | ARG363 | |
| A | TYR366 | |
| B | ARG363 | |
| B | TYR366 | |
| C | ARG363 | |
| C | TYR366 | |
| D | ARG363 | |
| D | TYR366 |
