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7KXP

BTK1 SOAKED WITH COMPOUND 25

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue X9V A 701
ChainResidue
AGLY411
AGLY480
ALEU528
AASP539
AHOH900
AHOH978
APHE413
AVAL416
AALA428
ALYS430
AGLU475
ATYR476
AMET477
AALA478

site_idAC2
Number of Residues5
Detailsbinding site for residue DMS A 702
ChainResidue
AARG520
ATRP563
ASER564
AHOH858
AHOH934

site_idAC3
Number of Residues6
Detailsbinding site for residue DMS A 703
ChainResidue
ATHR403
APHE404
ATHR628
AHOH850
AHOH862
AHOH922

site_idAC4
Number of Residues7
Detailsbinding site for residue DMS A 704
ChainResidue
ATYR598
AGLU599
AARG600
APHE601
AHOH883
AHOH1013
AHOH1053

site_idAC5
Number of Residues4
Detailsbinding site for residue DMS A 705
ChainResidue
ALYS595
AHIS620
AHOH889
AHOH1023

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK
ChainResidueDetails
ALEU408-LYS430

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV
ChainResidueDetails
APHE517-VAL529

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP521

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU408
ALYS430

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT
ChainResidueDetails
ATHR474

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY
ChainResidueDetails
ALEU542

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831
ChainResidueDetails
ATYR551

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER604

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15375214
ChainResidueDetails
ATYR617

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15375214
ChainResidueDetails
ASER623

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER659

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PDB entries from 2024-04-24

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