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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7KWH

Spermidine N-acetyltransferase SpeG K23-Y30 chimera from Vibrio cholerae and hSSAT

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004145molecular_functiondiamine N-acetyltransferase activity
A0005737cellular_componentcytoplasm
A0006598biological_processpolyamine catabolic process
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0046203biological_processspermidine catabolic process
A0046208biological_processspermine catabolic process
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0004145molecular_functiondiamine N-acetyltransferase activity
B0005737cellular_componentcytoplasm
B0006598biological_processpolyamine catabolic process
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
B0046203biological_processspermidine catabolic process
B0046208biological_processspermine catabolic process
B0046872molecular_functionmetal ion binding
C0000287molecular_functionmagnesium ion binding
C0004145molecular_functiondiamine N-acetyltransferase activity
C0005737cellular_componentcytoplasm
C0006598biological_processpolyamine catabolic process
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
C0046203biological_processspermidine catabolic process
C0046208biological_processspermine catabolic process
C0046872molecular_functionmetal ion binding
D0000287molecular_functionmagnesium ion binding
D0004145molecular_functiondiamine N-acetyltransferase activity
D0005737cellular_componentcytoplasm
D0006598biological_processpolyamine catabolic process
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
D0046203biological_processspermidine catabolic process
D0046208biological_processspermine catabolic process
D0046872molecular_functionmetal ion binding
E0000287molecular_functionmagnesium ion binding
E0004145molecular_functiondiamine N-acetyltransferase activity
E0005737cellular_componentcytoplasm
E0006598biological_processpolyamine catabolic process
E0016740molecular_functiontransferase activity
E0016746molecular_functionacyltransferase activity
E0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
E0046203biological_processspermidine catabolic process
E0046208biological_processspermine catabolic process
E0046872molecular_functionmetal ion binding
F0000287molecular_functionmagnesium ion binding
F0004145molecular_functiondiamine N-acetyltransferase activity
F0005737cellular_componentcytoplasm
F0006598biological_processpolyamine catabolic process
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
F0046203biological_processspermidine catabolic process
F0046208biological_processspermine catabolic process
F0046872molecular_functionmetal ion binding
G0000287molecular_functionmagnesium ion binding
G0004145molecular_functiondiamine N-acetyltransferase activity
G0005737cellular_componentcytoplasm
G0006598biological_processpolyamine catabolic process
G0016740molecular_functiontransferase activity
G0016746molecular_functionacyltransferase activity
G0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
G0046203biological_processspermidine catabolic process
G0046208biological_processspermine catabolic process
G0046872molecular_functionmetal ion binding
H0000287molecular_functionmagnesium ion binding
H0004145molecular_functiondiamine N-acetyltransferase activity
H0005737cellular_componentcytoplasm
H0006598biological_processpolyamine catabolic process
H0016740molecular_functiontransferase activity
H0016746molecular_functionacyltransferase activity
H0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
H0046203biological_processspermidine catabolic process
H0046208biological_processspermine catabolic process
H0046872molecular_functionmetal ion binding
I0000287molecular_functionmagnesium ion binding
I0004145molecular_functiondiamine N-acetyltransferase activity
I0005737cellular_componentcytoplasm
I0006598biological_processpolyamine catabolic process
I0016740molecular_functiontransferase activity
I0016746molecular_functionacyltransferase activity
I0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
I0046203biological_processspermidine catabolic process
I0046208biological_processspermine catabolic process
I0046872molecular_functionmetal ion binding
J0000287molecular_functionmagnesium ion binding
J0004145molecular_functiondiamine N-acetyltransferase activity
J0005737cellular_componentcytoplasm
J0006598biological_processpolyamine catabolic process
J0016740molecular_functiontransferase activity
J0016746molecular_functionacyltransferase activity
J0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
J0046203biological_processspermidine catabolic process
J0046208biological_processspermine catabolic process
J0046872molecular_functionmetal ion binding
K0000287molecular_functionmagnesium ion binding
K0004145molecular_functiondiamine N-acetyltransferase activity
K0005737cellular_componentcytoplasm
K0006598biological_processpolyamine catabolic process
K0016740molecular_functiontransferase activity
K0016746molecular_functionacyltransferase activity
K0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
K0046203biological_processspermidine catabolic process
K0046208biological_processspermine catabolic process
K0046872molecular_functionmetal ion binding
L0000287molecular_functionmagnesium ion binding
L0004145molecular_functiondiamine N-acetyltransferase activity
L0005737cellular_componentcytoplasm
L0006598biological_processpolyamine catabolic process
L0016740molecular_functiontransferase activity
L0016746molecular_functionacyltransferase activity
L0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
L0046203biological_processspermidine catabolic process
L0046208biological_processspermine catabolic process
L0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue PO4 A 201
ChainResidue
AGLY95
ALYS96
AGLY97
APHE98
AALA99
site_idAC2
Number of Residues5
Detailsbinding site for residue PO4 B 201
ChainResidue
BALA99
BGLY95
BLYS96
BGLY97
BPHE98
site_idAC3
Number of Residues3
Detailsbinding site for residue PO4 C 201
ChainResidue
CGLY95
CGLY97
CALA99
site_idAC4
Number of Residues6
Detailsbinding site for residue PO4 D 201
ChainResidue
DGLY95
DLYS96
DGLY97
DPHE98
DALA99
DLEU133
site_idAC5
Number of Residues5
Detailsbinding site for residue PO4 F 201
ChainResidue
FGLY95
FLYS96
FGLY97
FPHE98
FALA99
site_idAC6
Number of Residues5
Detailsbinding site for residue PO4 J 201
ChainResidue
JGLY95
JLYS96
JGLY97
JPHE98
JALA99
site_idAC7
Number of Residues6
Detailsbinding site for residue PO4 K 201
ChainResidue
KGLY95
KLYS96
KGLY97
KPHE98
KALA99
KLEU133
site_idAC8
Number of Residues5
Detailsbinding site for residue PO4 H 201
ChainResidue
HGLY95
HLYS96
HGLY97
HPHE98
HALA99
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1727
DetailsDomain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A951","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with polyamine.","authors":["Filippova E.V.","Minasov G.","Shuvalova L.","Kiryukhina O.","Kuhn M.L.","Anderson W.F."]}},{"source":"PDB","id":"4MJ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MI4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26410587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CNP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues96
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues108
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R57","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsSite: {"description":"Could be important for selectivity toward long polyamines","evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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