7KUH
MicroED structure of mVDAC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0000166 | molecular_function | nucleotide binding |
| X | 0001662 | biological_process | behavioral fear response |
| X | 0005244 | molecular_function | voltage-gated monoatomic ion channel activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005524 | molecular_function | ATP binding |
| X | 0005739 | cellular_component | mitochondrion |
| X | 0005741 | cellular_component | mitochondrial outer membrane |
| X | 0005743 | cellular_component | mitochondrial inner membrane |
| X | 0005757 | cellular_component | mitochondrial permeability transition pore complex |
| X | 0005886 | cellular_component | plasma membrane |
| X | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| X | 0006811 | biological_process | monoatomic ion transport |
| X | 0006820 | biological_process | monoatomic anion transport |
| X | 0006869 | biological_process | lipid transport |
| X | 0006915 | biological_process | apoptotic process |
| X | 0007268 | biological_process | chemical synaptic transmission |
| X | 0007270 | biological_process | neuron-neuron synaptic transmission |
| X | 0007612 | biological_process | learning |
| X | 0008142 | molecular_function | oxysterol binding |
| X | 0008289 | molecular_function | lipid binding |
| X | 0008308 | molecular_function | voltage-gated monoatomic anion channel activity |
| X | 0015288 | molecular_function | porin activity |
| X | 0015485 | molecular_function | cholesterol binding |
| X | 0016020 | cellular_component | membrane |
| X | 0019901 | molecular_function | protein kinase binding |
| X | 0030855 | biological_process | epithelial cell differentiation |
| X | 0031210 | molecular_function | phosphatidylcholine binding |
| X | 0031966 | cellular_component | mitochondrial membrane |
| X | 0036444 | biological_process | calcium import into the mitochondrion |
| X | 0042645 | cellular_component | mitochondrial nucleoid |
| X | 0042802 | molecular_function | identical protein binding |
| X | 0043065 | biological_process | positive regulation of apoptotic process |
| X | 0043066 | biological_process | negative regulation of apoptotic process |
| X | 0043209 | cellular_component | myelin sheath |
| X | 0044325 | molecular_function | transmembrane transporter binding |
| X | 0045121 | cellular_component | membrane raft |
| X | 0045202 | cellular_component | synapse |
| X | 0046930 | cellular_component | pore complex |
| X | 0055085 | biological_process | transmembrane transport |
| X | 0097001 | molecular_function | ceramide binding |
| X | 0098656 | biological_process | monoatomic anion transmembrane transport |
| X | 0110099 | biological_process | negative regulation of calcium import into the mitochondrion |
| X | 1901524 | biological_process | regulation of mitophagy |
| X | 1905091 | biological_process | positive regulation of type 2 mitophagy |
| X | 1990542 | biological_process | mitochondrial transmembrane transport |
| X | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00558 |
| Number of Residues | 23 |
| Details | EUKARYOTIC_PORIN Eukaryotic mitochondrial porin signature. YqvDPdAcfsAKVNNssliGLgY |
| Chain | Residue | Details |
| X | TYR225-TYR247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 163 |
| Details | Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"18988731","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24908397","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C69","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Z2L0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by NEK1","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 5 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"32047033","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"32047033","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
